Aldo-keto reductase family 1 member C3


NameAldo-keto reductase family 1 member C3
Synonyms1.-.-.- 17-beta-HSD 5 17-beta-hydroxysteroid dehydrogenase type 5 3-alpha-HSD type 2 3-alpha-HSD type II, brain 3-alpha-hydroxysteroid dehydrogenase type 2 Chlordecone reductase homolog HAKRb DD-3 DD3 DDH1 Dihydrodiol dehydrogenase 3 Dihydrodiol dehydrogenase type I HA1753 HSD17B5 Indanol dehydrogenase KIAA0119 PGFS Prostaglandin F synthase Testosterone 17-beta-dehydrogenase 5 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Gene NameAKR1C3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037052|Aldo-keto reductase family 1 member C3
MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM
SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
RNLHYFNSDSFASHPNYPYSDEY
Number of residues323
Molecular Weight36852.89
Theoretical pI8.06
GO Classification
Functions
    androsterone dehydrogenase activity
    oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
    geranylgeranyl reductase activity
    ketoreductase activity
    aldo-keto reductase (NADP) activity
    retinal dehydrogenase activity
    alditol
    15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
    prostaglandin D2 11-ketoreductase activity
    retinol dehydrogenase activity
    dihydrotestosterone 17-beta-dehydrogenase activity
    ketosteroid monooxygenase activity
    prostaglandin-F synthase activity
    phenanthrene 9,10-monooxygenase activity
    delta4-3-oxosteroid 5beta-reductase activity
    trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
    testosterone 17-beta-dehydrogenase (NADP+) activity
    testosterone dehydrogenase (NAD+) activity
    indanol dehydrogenase activity
Processes
    protein import into nucleus, translocation
    daunorubicin metabolic process
    positive regulation of cell death
    keratinocyte differentiation
    doxorubicin metabolic process
    arachidonic acid metabolic process
    regulation of retinoic acid receptor signaling pathway
    cellular response to starvation
    progesterone metabolic process
    response to nutrient
    cellular response to reactive oxygen species
    cyclooxygenase pathway
    oxidation-reduction process
    renal absorption
    retinoid metabolic process
    prostaglandin metabolic process
    steroid metabolic process
    male gonad development
    farnesol catabolic process
    cellular response to corticosteroid stimulus
    G-protein coupled receptor signaling pathway
    cellular response to cadmium ion
    retinal metabolic process
    cellular response to prostaglandin stimulus
    positive regulation of cell proliferation
    multicellular organismal macromolecule metabolic process
    positive regulation of reactive oxygen species metabolic process
    positive regulation of protein kinase B signaling
    negative regulation of retinoic acid biosynthetic process
    phototransduction, visible light
    cellular response to prostaglandin D stimulus
    regulation of testosterone biosynthetic process
    small molecule metabolic process
    positive regulation of endothelial cell apoptotic process
    testosterone biosynthetic process
    cellular response to jasmonic acid stimulus
    cellular response to calcium ion
Components
    cytosol
    extracellular exosome
    intracellular
    cytoplasm
    nucleus
General FunctionTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
Specific FunctionCatalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
Transmembrane Regions
GenBank Protein ID4261711
UniProtKB IDP42330
UniProtKB Entry NameAK1C3_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0018982|Aldo-keto reductase family 1 member C3 (AKR1C3)
ATGGATTCAAAACATCAGTGTTTGAAGCTAAATGATGGTCACTTCATGCCTGTCCTGGGA
TTTGGCACCTATGCACCTCCAGAGGTTCCGAGAAGTAAAGCTTTGGAGGTCACAAAATTA
GCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCATTTATACAATAATGAGGAGCAG
GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTC
TACACTTCAAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGTCCGACCAGCCTTGGAA
AACTCACTGAAGAAAGCTCAATTGGACTATGTTGACCTCTATCTTATTCATTCTCCAATG
TCTCTAAAGCCAGGTGAGGAACTTTCACCAACAGATGAAAATGGAAAAGTAATATTTGAC
ATAGTGGATCTCTGTACCACCTGGGAGGCCATGGAGAAGTGTAAGGATGCAGGATTGGCC
AAGTCCATTGGGGTGTCAAACTTCAACCGCAGGCAGCTGGAGATGATCCTCAACAAGCCA
GGACTCAAGTACAAGCCTGTCTGCAACCAGGTAGAATGTCATCCGTATTTCAACCGGAGT
AAATTGCTAGATTTCTGCAAGTCGAAAGATATTGTTCTGGTTGCCTATAGTGCTCTGGGA
TCTCAACGAGACAAACGATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCAGTC
CTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAG
CTGCAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAAC
GTGCAGGTTTTTGAGTTCCAGTTGACTGCAGAGGACATGAAAGCCATAGATGGCCTAGAC
AGAAATCTCCACTATTTTAACAGTGATAGTTTTGCTAGCCACCCTAATTATCCATATTCA
GATGAATATTAA
GenBank Gene IDS68288
GeneCard IDNone
GenAtlas IDAKR1C3
HGNC IDHGNC:386
Chromosome Location10
Locus10p15-p14
References
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Related FRC


FRCD ID Name Exact Mass Structure



Ibuprofen




206.285



Androstenedione




286.4