Aldo-keto reductase family 1 member C3
Name | Aldo-keto reductase family 1 member C3 |
---|---|
Synonyms | 1.-.-.- 17-beta-HSD 5 17-beta-hydroxysteroid dehydrogenase type 5 3-alpha-HSD type 2 3-alpha-HSD type II, brain 3-alpha-hydroxysteroid dehydrogenase type 2 Chlordecone reductase homolog HAKRb DD-3 DD3 DDH1 Dihydrodiol dehydrogenase 3 Dihydrodiol dehydrogenase type I HA1753 HSD17B5 Indanol dehydrogenase KIAA0119 PGFS Prostaglandin F synthase Testosterone 17-beta-dehydrogenase 5 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase |
Gene Name | AKR1C3 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0037052|Aldo-keto reductase family 1 member C3 MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD RNLHYFNSDSFASHPNYPYSDEY |
Number of residues | 323 |
Molecular Weight | 36852.89 |
Theoretical pI | 8.06 |
GO Classification |
Functions
androsterone dehydrogenase activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor geranylgeranyl reductase activity ketoreductase activity aldo-keto reductase (NADP) activity retinal dehydrogenase activity alditol 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity prostaglandin D2 11-ketoreductase activity retinol dehydrogenase activity dihydrotestosterone 17-beta-dehydrogenase activity ketosteroid monooxygenase activity prostaglandin-F synthase activity phenanthrene 9,10-monooxygenase activity delta4-3-oxosteroid 5beta-reductase activity trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity testosterone 17-beta-dehydrogenase (NADP+) activity testosterone dehydrogenase (NAD+) activity indanol dehydrogenase activity Processes
protein import into nucleus, translocation daunorubicin metabolic process positive regulation of cell death keratinocyte differentiation doxorubicin metabolic process arachidonic acid metabolic process regulation of retinoic acid receptor signaling pathway cellular response to starvation progesterone metabolic process response to nutrient cellular response to reactive oxygen species cyclooxygenase pathway oxidation-reduction process renal absorption retinoid metabolic process prostaglandin metabolic process steroid metabolic process male gonad development farnesol catabolic process cellular response to corticosteroid stimulus G-protein coupled receptor signaling pathway cellular response to cadmium ion retinal metabolic process cellular response to prostaglandin stimulus positive regulation of cell proliferation multicellular organismal macromolecule metabolic process positive regulation of reactive oxygen species metabolic process positive regulation of protein kinase B signaling negative regulation of retinoic acid biosynthetic process phototransduction, visible light cellular response to prostaglandin D stimulus regulation of testosterone biosynthetic process small molecule metabolic process positive regulation of endothelial cell apoptotic process testosterone biosynthetic process cellular response to jasmonic acid stimulus cellular response to calcium ion Components
cytosol extracellular exosome intracellular cytoplasm nucleus |
General Function | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity |
Specific Function | Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. |
Transmembrane Regions | |
GenBank Protein ID | 4261711 |
UniProtKB ID | P42330 |
UniProtKB Entry Name | AK1C3_HUMAN |
Cellular Location | Cytoplasm |
Gene sequence | >lcl|BSEQ0018982|Aldo-keto reductase family 1 member C3 (AKR1C3) ATGGATTCAAAACATCAGTGTTTGAAGCTAAATGATGGTCACTTCATGCCTGTCCTGGGA TTTGGCACCTATGCACCTCCAGAGGTTCCGAGAAGTAAAGCTTTGGAGGTCACAAAATTA GCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCATTTATACAATAATGAGGAGCAG GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTC TACACTTCAAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGTCCGACCAGCCTTGGAA AACTCACTGAAGAAAGCTCAATTGGACTATGTTGACCTCTATCTTATTCATTCTCCAATG TCTCTAAAGCCAGGTGAGGAACTTTCACCAACAGATGAAAATGGAAAAGTAATATTTGAC ATAGTGGATCTCTGTACCACCTGGGAGGCCATGGAGAAGTGTAAGGATGCAGGATTGGCC AAGTCCATTGGGGTGTCAAACTTCAACCGCAGGCAGCTGGAGATGATCCTCAACAAGCCA GGACTCAAGTACAAGCCTGTCTGCAACCAGGTAGAATGTCATCCGTATTTCAACCGGAGT AAATTGCTAGATTTCTGCAAGTCGAAAGATATTGTTCTGGTTGCCTATAGTGCTCTGGGA TCTCAACGAGACAAACGATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCAGTC CTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAG CTGCAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAAC GTGCAGGTTTTTGAGTTCCAGTTGACTGCAGAGGACATGAAAGCCATAGATGGCCTAGAC AGAAATCTCCACTATTTTAACAGTGATAGTTTTGCTAGCCACCCTAATTATCCATATTCA GATGAATATTAA |
GenBank Gene ID | S68288 |
GeneCard ID | None |
GenAtlas ID | AKR1C3 |
HGNC ID | HGNC:386 |
Chromosome Location | 10 |
Locus | 10p15-p14 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Ibuprofen |
206.285 |
||
Androstenedione |
286.4 |