Caspase-3
Name | Caspase-3 |
---|---|
Synonyms | 3.4.22.56 Apopain CASP-3 CPP-32 CPP32 Cysteine protease CPP32 Protein Yama SCA-1 SREBP cleavage activity 1 |
Gene Name | CASP3 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0016333|Caspase-3 MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH |
Number of residues | 277 |
Molecular Weight | 31607.58 |
Theoretical pI | 6.51 |
GO Classification |
Functions
cysteine-type endopeptidase activity involved in execution phase of apoptosis aspartic-type endopeptidase activity cysteine-type endopeptidase activity involved in apoptotic process cysteine-type endopeptidase activity peptidase activity phospholipase A2 activator activity cyclin-dependent protein serine/threonine kinase inhibitor activity Processes
hippocampus development learning or memory sensory perception of sound regulation of cysteine-type endopeptidase activity involved in apoptotic process neuron apoptotic process negative regulation of activated T cell proliferation programmed cell death keratinocyte differentiation apoptotic process response to amino acid response to X-ray heart development T cell homeostasis apoptotic signaling pathway cellular response to organic cyclic compound negative regulation of apoptotic process platelet formation activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c erythrocyte differentiation cell fate commitment neurotrophin TRK receptor signaling pathway neuron differentiation glial cell apoptotic process hippo signaling positive regulation of neuron apoptotic process response to hypoxia negative regulation of B cell proliferation intrinsic apoptotic signaling pathway negative regulation of cyclin-dependent protein serine/threonine kinase activity extrinsic apoptotic signaling pathway cellular response to DNA damage stimulus wound healing execution phase of apoptosis proteolysis response to nicotine cellular component disassembly involved in execution phase of apoptosis extracellular matrix disassembly response to glucose B cell homeostasis extracellular matrix organization response to glucocorticoid apoptotic DNA fragmentation response to drug response to cobalt ion extrinsic apoptotic signaling pathway in absence of ligand response to estradiol response to lipopolysaccharide response to antibiotic response to UV response to hydrogen peroxide response to tumor necrosis factor Components
plasma membrane cytosol nucleoplasm death-inducing signaling complex membrane raft nucleus |
General Function | Phospholipase a2 activator activity |
Specific Function | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. |
Transmembrane Regions | |
GenBank Protein ID | 561666 |
UniProtKB ID | P42574 |
UniProtKB Entry Name | CASP3_HUMAN |
Cellular Location | Cytoplasm |
Gene sequence | >lcl|BSEQ0016334|Caspase-3 (CASP3) ATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATC ATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGAT TATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGA ATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAAC TTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATG CGTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGC CATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACA AACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATT CAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGAT GACATGGCGTGTCATAAAATACCAGTGGAGGCCGACTTCTTGTATGCATACTCCACAGCA CCTGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGT GCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAAC CGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAA CAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAA |
GenBank Gene ID | U13737 |
GeneCard ID | None |
GenAtlas ID | CASP3 |
HGNC ID | HGNC:1504 |
Chromosome Location | 4 |
Locus | 4q34 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Melatonin |
232.283 |