Neutral amino acid transporter A


NameNeutral amino acid transporter A
SynonymsAlanine/serine/cysteine/threonine transporter 1 ASCT-1 ASCT1 SATT Solute carrier family 1 member 4
Gene NameSLC1A4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000958|Neutral amino acid transporter A
MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLGA
ALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAY
FGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFP
SNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKL
GSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFA
SILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENN
GVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGA
AGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQK
ATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL
Number of residues532
Molecular Weight55722.455
Theoretical pI6.18
GO Classification
Functions
    L-proline transmembrane transporter activity
    L-glutamine transmembrane transporter activity
    L-cystine transmembrane transporter activity
    L-hydroxyproline transmembrane transporter activity
    sodium
    L-serine transmembrane transporter activity
    L-alanine transmembrane transporter activity
    L-threonine transmembrane transporter activity
    chloride channel activity
Processes
    proline transmembrane transport
    glutamine transport
    proline transport
    L-cystine transport
    mitophagy in response to mitochondrial depolarization
    ion transport
    transmembrane transport
    L-alanine transport
    amino acid transport
    L-serine transport
    cognition
    synaptic transmission, glutamatergic
    chloride transport
    hydroxyproline transport
    chloride transmembrane transport
    threonine transport
Components
    centrosome
    plasma membrane
    melanosome
    cell surface
    integral component of membrane
    extracellular exosome
    intermediate filament
    integral component of plasma membrane
    membrane
    dendrite
    microtubule organizing center
    neuronal cell body
General FunctionSodium:dicarboxylate symporter activity
Specific FunctionTransporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence.
Transmembrane Regions42-62 88-108 119-139 217-237 257-277 298-318 328-348 373-393 418-438
GenBank Protein ID348012
UniProtKB IDP43007
UniProtKB Entry NameSATT_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0020463|Neutral amino acid transporter A (SLC1A4)
ATGAACATTTTAGGATTGGTCCTGTTTGCTCTGGTGTTAGGAGTGGCCTTAAAGAAACTA
GGCTCCGAAGGAGAAGACCTCATCCGTTTCTTCAATTCCCTCAACGAGGCGACGATGGTG
CTGGTGTCCTGGATTATGTGCTCAGCGACCCTTCCCTCTATGATGAAGTGCATTGAAGAG
AACAATGGTGTGGACAAGAGGATCAGCAGGTTTATTCTCCCCATCGGGGCCACCGTGAAC
ATGGACGGAGCAGCCATCTTCCAGTGTGTGGCCGCGGTGTTCATTGCGCAACTCAACAAC
GTAGAGCTCAACGCAGGACAGATTTTCACCATTCTAGTGACTGCCACAGCGTCCAGTGTT
GGAGCAGCAGGCGTGCCAGCTGGAGGGGTCCTCACCATTGCCATTATCCTGGAGGCCATT
GGGCTGCCTACTCATGACCTGCCTCTGATCCTGGCTGTGGACTGGATTGTGGACCGGACC
ACCACGGTGGTGAATGTGGAAGGGGATGCCCTGGGTGCAGGCATTCTCCACCACCTGAAT
CAGAAGGCAACAAAGAAAGGCGAGCAGGAACTTGCTGAGGTGAAAGTGGAAGCCATCCCC
AACTGCAAGTCTGAGGAGGAGACATCGCCCCTGGTGACACACCAGAACCCCGCTGGCCCC
GTGGCCAGTGCCCCAGAACTGGAATCCAAGGAGTCGGTTCTGTGA
GenBank Gene IDL14595
GeneCard IDNone
GenAtlas IDSLC1A4
HGNC IDHGNC:10942
Chromosome Location2
Locus2p15-p13
References
  1. Arriza JL, Kavanaugh MP, Fairman WA, Wu YN, Murdoch GH, North RA, Amara SG: Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family. J Biol Chem. 1993 Jul 25;268(21):15329-32.[8101838 ]
  2. Shafqat S, Tamarappoo BK, Kilberg MS, Puranam RS, McNamara JO, Guadano-Ferraz A, Fremeau RT Jr: Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters. J Biol Chem. 1993 Jul 25;268(21):15351-5.[8340364 ]
  3. Hofmann K, Duker M, Fink T, Lichter P, Stoffel W: Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15. Genomics. 1994 Nov 1;24(1):20-6.[7896285 ]
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