Prostaglandin E2 receptor EP2 subtype

NameProstaglandin E2 receptor EP2 subtype
SynonymsPGE receptor EP2 subtype Prostanoid EP2 receptor
Gene NamePTGER2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010263|Prostaglandin E2 receptor EP2 subtype
MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGR
RSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFS
LATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQ
YCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGS
GRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQA
LRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
Number of residues358
Molecular Weight39759.945
Theoretical pI9.19
GO Classification
Functions
    prostaglandin E receptor activity
Processes
    cellular response to prostaglandin E stimulus
regulation of cell proliferation
G-protein coupled receptor signaling pathway
response to lipopolysaccharide
adenylate cyclase-activating G-protein coupled receptor signaling pathway
response to progesterone
Components
    plasma membrane
integral component of plasma membrane
General FunctionProstaglandin e receptor activity
Specific FunctionReceptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
Transmembrane Regions24-47 66-91 112-132 152-176 199-223 263-286 300-323
GenBank Protein ID632650
UniProtKB IDP43116
UniProtKB Entry NamePE2R2_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010264|Prostaglandin E2 receptor EP2 subtype (PTGER2)
ATGGGCAATGCCTCCAATGACTCCCAGTCTGAGGACTGCGAGACGCGACAGTGGCTTCCC
CCAGGCGAAAGCCCAGCCATCAGCTCCGTCATGTTCTCGGCCGGGGTGCTGGGGAACCTC
ATAGCACTGGCGCTGCTGGCGCGCCGCTGGCGGGGGGACGTGGGGTGCAGCGCCGGCCGC
AGGAGCTCCCTCTCCTTGTTCCACGTGCTGGTGACCGAGCTGGTGTTCACCGACCTGCTC
GGGACCTGCCTCATCAGCCCAGTGGTACTGGCTTCGTACGCGCGGAACCAGACCCTGGTG
GCACTGGCGCCCGAGAGCCGCGCGTGCACCTACTTCGCTTTCGCCATGACCTTCTTCAGC
CTGGCCACGATGCTCATGCTCTTCGCCATGGCCCTGGAGCGCTACCTCTCGATCGGGCAC
CCCTACTTCTACCAGCGCCGCGTCTCGCGCTCCGGGGGCCTGGCCGTGCTGCCTGTCATC
TATGCAGTCTCCCTGCTCTTCTGCTCGCTGCCGCTGCTGGACTATGGGCAGTACGTCCAG
TACTGCCCCGGGACCTGGTGCTTCATCCGGCACGGGCGGACCGCTTACCTGCAGCTGTAC
GCCACCCTGCTGCTGCTTCTCATTGTCTCGGTGCTCGCCTGCAACTTCAGTGTCATTCTC
AACCTCATCCGCATGCACCGCCGAAGCCGGAGAAGCCGCTGCGGACCTTCCCTGGGCAGT
GGCCGGGGCGGCCCCGGGGCCCGCAGGAGAGGGGAAAGGGTGTCCATGGCGGAGGAGACG
GACCACCTCATTCTCCTGGCTATCATGACCATCACCTTCGCCGTCTGCTCCTTGCCTTTC
ACGATTTTTGCATATATGAATGAAACCTCTTCCCGAAAGGAAAAATGGGACCTCCAAGCT
CTTAGGTTTTTATCAATTAATTCAATAATTGACCCTTGGGTCTTTGCCATCCTTAGGCCT
CCTGTTCTGAGACTAATGCGTTCAGTCCTCTGTTGTCGGATTTCATTAAGAACACAAGAT
GCAACACAAACTTCCTGTTCTACACAGTCAGATGCCAGTAAACAGGCTGACCTTTGA
GenBank Gene IDU19487
GeneCard IDNone
GenAtlas IDPTGER2
HGNC IDHGNC:9594
Chromosome Location14
Locus14q22
References
  1. Regan JW, Bailey TJ, Pepperl DJ, Pierce KL, Bogardus AM, Donello JE, Fairbairn CE, Kedzie KM, Woodward DF, Gil DW: Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. Mol Pharmacol. 1994 Aug;46(2):213-20.[8078484 ]
  2. Smock SL, Pan LC, Castleberry TA, Lu B, Mather RJ, Owen TA: Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E(2) receptor EP2 subtype. Gene. 1999 Sep 17;237(2):393-402.[10521663 ]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]

Related FRC

FRCD ID Name Exact Mass Structure




F03892



Rotenone


394.423




F03972



Carbaril


201.225




F03981



Chlorpropham


213.661




F04044



Tetramethrin


331.412




F04050



Cypermethrin


416.298




F04333



Chlorothalonil


265.902




F04384



Permethrin


391.288




F05028



Azamethiphos


324.672




F05031



Bensulide


397.503




F05032



Bifenazate


300.358




F05044



Clofentezine


303.146




F05051



Cyprodinil


225.295




F05053



Dazomet


162.269




F05058



Difenoconazole


406.263




F05078



Flusilazole


315.399




F05085



Enilconazole


297.179




F05094



Lactofen


461.774




F05107



Mevinphos


224.15




F05112



Napropamide


271.36




F05123



Prochloraz


376.662




F05127



Propiconazole


342.22




F05130



Pyraclostrobin


387.82




F05132



Pyriproxyfen


321.376




F05140



Tebufenpyrad


333.86




F05143



Tetraconazole


372.145




F05180



2-Biphenylol


170.21




F05393



Captafol


349.047




F05395



Chlorethoxyfos


335.985




F05416



Fenarimol


331.196




F05417



Fenbuconazole


336.823




F05421



Forchlorfenuron


247.682




F05433



Prallethrin


300.398




F05434



Profenofos


373.626




F05445



Thiram


240.416




F05447



Triadimenol


295.767




F06003



Triflumizole


345.75




F04329



Bromoxynil


276.915




F05408



Diphenylamine


169.227




F05425



Isazofos


313.737




F03315



Methoxychlor


345.644