Gamma-aminobutyric acid receptor subunit alpha-2
| Name | Gamma-aminobutyric acid receptor subunit alpha-2 |
|---|---|
| Synonyms | GABA(A) receptor subunit alpha-2 |
| Gene Name | GABRA2 |
| Organism | Human |
| Amino acid sequence | >lcl|BSEQ0037005|Gamma-aminobutyric acid receptor subunit alpha-2 MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPG LGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASK IWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSC PLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVM TAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASV MIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRM SRIVFPVLFGTFNLVYWATYLNREPVLGVSP |
| Number of residues | 451 |
| Molecular Weight | 51325.85 |
| Theoretical pI | 9.41 |
| GO Classification |
Functions
GABA-A receptor activity benzodiazepine receptor activity inhibitory extracellular ligand-gated ion channel activity chloride channel activity Processes
response to drug chloride transmembrane transport regulation of membrane potential neurotransmitter transport gamma-aminobutyric acid signaling pathway neurological system process synaptic transmission transmembrane transport ion transmembrane transport regulation of neurotransmitter levels Components
neuron projection axon plasma membrane chloride channel complex GABA-A receptor complex cell junction integral component of synaptic vesicle membrane integral component of plasma membrane postsynaptic membrane |
| General Function | Inhibitory extracellular ligand-gated ion channel activity |
| Specific Function | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. |
| Transmembrane Regions | 252-273 279-300 313-334 420-441 |
| GenBank Protein ID | 386422 |
| UniProtKB ID | P47869 |
| UniProtKB Entry Name | GBRA2_HUMAN |
| Cellular Location | Cell junction |
| Gene sequence | >lcl|BSEQ0010268|Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2) ATGAAGACAAAATTGAACATCTACAACATGCAGTTCCTGCTTTTTGTTTTCTTGGTGTGG GACCCTGCCAGGTTGGTGCTGGCTAACATCCAAGAAGATGAGGCTAAAAATAACATTACC ATCTTTACGAGAATTCTTGACAGACTTCTGGATGGTTACGATAATCGGCTTAGACCAGGA CTGGGAGACAGTATTACTGAAGTCTTCACTAACATCTACGTGACCAGTTTTGGCCCTGTC TCAGATACAGATATGGAATATACAATTGATGTTTTCTTTCGACAAAAATGGAAAGATGAA CGTTTAAAATTTAAAGGTCCTATGAATATCCTTCGACTAAACAATTTAATGGCTAGCAAA ATCTGGACTCCAGATACCTTTTTTCACAATGGGAAAAAATCAGTAGCTCATAATATGACA ATGCCAAATAAGTTGCTTCGAATTCAGGATGATGGGACTCTGCTGTATACCATGAGGCTT ACAGTTCAAGCTGAATGCCCAATGCACTTGGAGGATTTCCCAATGGATGCTCATTCATGT CCTCTGAAATTTGGCAGCTATGCATATACAACTTCAGAGGTCACTTATATTTGGACTTAC AATGCATCTGATTCAGTACAGGTTGCTCCTGATGGCTCTAGGTTAAATCAATATGACCTG CTGGGCCAATCAATCGGAAAGGAGACAATTAAATCCAGTACAGGTGAATATACTGTAATG ACAGCTCATTTCCACCTGAAAAGAAAAATTGGGTATTTTGTGATTCAAACCTATCTGCCT TGCATCATGACTGTCATTCTCTCCCAAGTTTCATTCTGGCTTAACAGAGAATCTGTGCCT GCAAGAACTGTGTTTGGAGTAACAACTGTCCTAACAATGACAACTCTAAGCATCAGTGCT CGGAATTCTCTCCCCAAAGTGGCTTATGCAACTGCCATGGACTGGTTTATTGCTGTTTGT TATGCATTTGTGTTCTCTGCCCTAATTGAATTTGCAACTGTTAATTACTTCACCAAAAGA GGATGGGCTTGGGATGGGAAGAGTGTAGTAAATGACAAGAAAAAAGAAAAGGCTTCCGTT ATGATACAGAACAACGCTTATGCAGTGGCTGTTGCCAATTATGCCCCGAATCTTTCAAAA GATCCAGTTCTCTCCACCATCTCCAAGAGTGCAACCACGCCAGAACCCAACAAGAAGCCA GAAAACAAGCCAGCTGAAGCAAAGAAAACTTTCAACAGTGTTAGCAAAATTGACAGAATG TCCAGAATAGTTTTTCCAGTTTTGTTTGGTACCTTTAATTTAGTTTACTGGGCTACATAT TTAAACAGAGAACCTGTATTAGGGGTCAGTCCTTGA |
| GenBank Gene ID | S62907 |
| GeneCard ID | None |
| GenAtlas ID | GABRA2 |
| HGNC ID | HGNC:4076 |
| Chromosome Location | 4 |
| Locus | 4p12 |
| References |
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