G protein-activated inward rectifier potassium channel 1
Name | G protein-activated inward rectifier potassium channel 1 |
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Synonyms | GIRK-1 GIRK1 Inward rectifier K(+) channel Kir3.1 Potassium channel, inwardly rectifying subfamily J member 3 |
Gene Name | KCNJ3 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0002047|G protein-activated inward rectifier potassium channel 1 MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNL GSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNY TPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCM FIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPE GEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILE GIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKE QEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMS STTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGG AARMEGNLPAKLRKMNSDRFT |
Number of residues | 501 |
Molecular Weight | 56602.84 |
Theoretical pI | 8.36 |
GO Classification |
Functions
G-protein activated inward rectifier potassium channel activity Processes
response to electrical stimulus regulation of ion transmembrane transport potassium ion transport synaptic transmission potassium ion import Components
T-tubule plasma membrane voltage-gated potassium channel complex external side of plasma membrane integral component of plasma membrane |
General Function | G-protein activated inward rectifier potassium channel activity |
Specific Function | This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. |
Transmembrane Regions | 81-105 158-179 |
GenBank Protein ID | 1055028 |
UniProtKB ID | P48549 |
UniProtKB Entry Name | KCNJ3_HUMAN |
Cellular Location | Membrane |
Gene sequence | >lcl|BSEQ0010718|G protein-activated inward rectifier potassium channel 1 (KCNJ3) ATGTCTGCACTCCGAAGGAAATTTGGGGACGATTATCAGGTAGTGACCACATCGTCCAGC GGCTCGGGCTTGCAGCCCCAGGGGCCAGGCCAGGACCCTCAGCAGCAGCTTGTGCCCAAG AAGAAGCGGCAGCGGTTCGTGGACAAGAACGGCCGGTGCAATGTACAGCACGGCAACCTG GGCAGCGAGACAAGCCGCTACCTCTCGGACCTCTTCACCACGCTGGTGGACCTCAAGTGG CGCTGGAACCTCTTCATCTTCATTCTCACCTACACCGTGGCCTGGCTTTTCATGGCGTCC ATGTGGTGGGTGATCGCCTACACTCGGGGCGACCTGAACAAAGCCCACGTCGGTAACTAC ACGCCTTGCGTGGCCAATGTCTATAACTTCCCTTCTGCCTTCCTCTTCTTCATCGAGACG GAGGCCACCATCGGCTATGGCTACCGATACATCACAGACAAGTGCCCCGAGGGCATCATC CTCTTCCTCTTCCAGTCCATCCTGGGCTCCATCGTGGACGCCTTCCTCATCGGCTGCATG TTCATCAAGATGTCCCAGCCCAAGAAGCGCGCCGAGACCCTCATGTTCAGCGAGCACGCG GTGATCTCCATGAGGGACGGAAAACTCACGCTTATGTTCCGGGTGGGCAACCTGCGCAAC AGCCACATGGTCTCCGCGCAGATTCGCTGCAAGCTGCTCAAAGGATGA |
GenBank Gene ID | U39196 |
GeneCard ID | None |
GenAtlas ID | KCNJ3 |
HGNC ID | HGNC:6264 |
Chromosome Location | 2 |
Locus | 2q24.1 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Ethanol |
46.07 |
||
Barium |
137.327 |