Neuropeptide Y receptor type 2
Name | Neuropeptide Y receptor type 2 |
---|---|
Synonyms | NPY-Y2 receptor NPY2-R Y2 receptor |
Gene Name | NPY2R |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0019283|Neuropeptide Y receptor type 2 MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSI ILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGP VLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLA SPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYT RIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDL KEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAK KNLEVRKNSGPNDSFTEATNV |
Number of residues | 381 |
Molecular Weight | 42730.69 |
Theoretical pI | 7.26 |
GO Classification |
Functions
receptor activity calcium channel regulator activity peptide YY receptor activity neuropeptide Y receptor activity Processes
positive regulation of smooth muscle contraction behavioral fear response negative regulation of excitatory postsynaptic potential cell surface receptor signaling pathway negative regulation of cAMP biosynthetic process negative regulation of neurological system process locomotory behavior feeding behavior adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway positive regulation of dopamine secretion neuropeptide signaling pathway positive regulation of cell-substrate adhesion synaptic transmission negative regulation of synaptic transmission, glutamatergic secretion positive regulation of peptide secretion outflow tract morphogenesis regulation of sensory perception of pain cardiac left ventricle morphogenesis positive regulation of cytosolic calcium ion concentration nitric oxide mediated signal transduction negative regulation of secretion positive regulation of circadian sleep/wake cycle, non-REM sleep negative regulation of feeding behavior Components
plasma membrane nonmotile primary cilium cytosol integral component of plasma membrane |
General Function | Receptor activity |
Specific Function | Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid. |
Transmembrane Regions | 52-72 87-107 125-145 166-186 217-237 269-289 305-325 |
GenBank Protein ID | |
UniProtKB ID | P49146 |
UniProtKB Entry Name | NPY2R_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0019284|Neuropeptide Y receptor type 2 (NPY2R) ATGGGTCCAATAGGTGCAGAGGCTGATGAGAACCAGACAGTGGAAGAAATGAAGGTGGAA CAATACGGGCCACAAACAACTCCTAGAGGTGAACTGGTCCCTGACCCTGAGCCAGAGCTT ATAGATAGTACCAAGCTGATTGAGGTACAAGTTGTTCTCATATTGGCCTACTGCTCCATC ATCTTGCTTGGGGTAATTGGCAACTCCTTGGTGATCCATGTGGTGATCAAATTCAAGAGC ATGCGCACAGTAACCAACTTTTTCATTGCCAATCTGGCTGTGGCAGATCTTTTGGTGAAC ACTCTGTGTCTACCGTTCACTCTTACCTATACCTTAATGGGGGAGTGGAAAATGGGTCCT GTCCTGTGCCACCTGGTGCCCTATGCCCAGGGCCTGGCAGTACAAGTATCCACAATCACC TTGACAGTAATTGCCCTGGACCGGCACAGGTGCATCGTCTACCACCTAGAGAGCAAGATC TCCAAGCGAATCAGCTTCCTGATTATTGGCTTGGCCTGGGGCATCAGTGCCCTGCTGGCA AGTCCCCTGGCCATCTTCCGGGAGTATTCGCTGATTGAGATCATCCCGGACTTTGAGATT GTGGCCTGTACTGAAAAGTGGCCTGGCGAGGAGAAGAGCATCTATGGCACTGTCTATAGT CTTTCTTCCTTGTTGATCTTGTATGTTTTGCCTCTGGGCATTATATCATTTTCCTACACT CGCATTTGGAGTAAATTGAAGAACCATGTCAGTCCTGGAGCTGCAAATGACCACTACCAT CAGCGAAGGCAAAAAACCACCAAAATGCTGGTGTGTGTGGTGGTGGTGTTTGCGGTCAGC TGGCTGCCTCTCCATGCCTTCCAGCTTGCCGTTGACATTGACAGCCAGGTCCTGGACCTG AAGGAGTACAAACTCATCTTCACAGTGTTCCACATCATCGCCATGTGCTCCACTTTTGCC AATCCCCTTCTCTATGGCTGGATGAACAGCAACTACAGAAAGGCTTTCCTCTCGGCCTTC CGCTGTGAGCAGCGGTTGGATGCCATTCACTCTGAGGTGTCCGTGACATTCAAGGCTAAA AAGAACCTGGAGGTCAGAAAGAACAGTGGCCCCAATGACTCTTTCACAGAGGCTACCAAT GTCTAA |
GenBank Gene ID | U36269 |
GeneCard ID | None |
GenAtlas ID | NPY2R |
HGNC ID | HGNC:7957 |
Chromosome Location | 4 |
Locus | 4q31 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Mercuric chloride |
271.492 |