Alpha-tocopherol transfer protein
Name | Alpha-tocopherol transfer protein |
---|---|
Synonyms | Alpha-TTP TPP1 |
Gene Name | TTPA |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0010447|Alpha-tocopherol transfer protein MAEARSQPSAGPQLNALPDHSPLLQPGLAALRRRAREAGVPLAPLPLTDSFLLRFLRARD FDLDLAWRLLKNYYKWRAECPEISADLHPRSIIGLLKAGYHGVLRSRDPTGSKVLIYRIA HWDPKVFTAYDVFRVSLITSELIVQEVETQRNGIKAIFDLEGWQFSHAFQITPSVAKKIA AVLTDSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKERIHMHGNNYKQSLLQHFPDI LPLEYGGEEFSMEDICQEWTNFIMKSEDYLSSISESIQ |
Number of residues | 278 |
Molecular Weight | 31749.305 |
Theoretical pI | 7.78 |
GO Classification |
Functions
phosphatidylinositol-3,4-bisphosphate binding transporter activity vitamin E binding phosphatidylinositol-4,5-bisphosphate binding Processes
response to pH transport embryonic placenta development vitamin transport intermembrane transport intracellular pH reduction lipid metabolic process negative regulation of cell death response to toxic substance negative regulation of establishment of blood-brain barrier response to nutrient vitamin E metabolic process Components
late endosome cytosol |
General Function | Vitamin e binding |
Specific Function | Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897). Binds both phosphatidylinol 3,4-bisphosphate and phosphatidylinol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity). |
Transmembrane Regions | |
GenBank Protein ID | 699601 |
UniProtKB ID | P49638 |
UniProtKB Entry Name | TTPA_HUMAN |
Cellular Location | Cytoplasm |
Gene sequence | >lcl|BSEQ0010448|Alpha-tocopherol transfer protein (TTPA) ATGGCAGAGGCGCGATCCCAGCCCTCGGCGGGGCCGCAGCTCAACGCGCTACCGGACCAC TCTCCGTTGCTGCAGCCGGGCCTGGCGGCGCTGCGGCGCCGGGCCCGGGAAGCTGGCGTC CCGCTCGCGCCGCTGCCGCTCACCGACTCCTTCCTGCTGCGGTTCCTGCGCGCCCGGGAT TTCGATCTGGACCTGGCCTGGCGGTTACTAAAAAACTATTATAAGTGGAGAGCAGAATGT CCAGAAATAAGTGCAGATCTACACCCTAGAAGTATTATTGGCCTCCTAAAGGCTGGCTAC CATGGAGTCCTGAGATCCAGGGATCCCACTGGCAGCAAAGTTCTTATTTACAGAATCGCA CACTGGGACCCCAAAGTTTTTACAGCTTATGACGTATTTCGAGTAAGTCTAATCACATCC GAGCTTATTGTACAGGAGGTAGAAACTCAGCGGAATGGAATCAAGGCTATCTTTGATCTG GAAGGTTGGCAGTTTTCTCATGCTTTTCAAATCACTCCATCCGTAGCCAAGAAGATTGCT GCTGTACTTACGGATTCATTTCCATTGAAAGTTCGTGGCATCCATTTGATAAATGAACCA GTAATTTTCCATGCTGTCTTTTCCATGATCAAACCATTCCTGACTGAAAAAATTAAGGAA CGGATTCACATGCATGGGAACAACTACAAACAAAGCTTGCTTCAGCATTTCCCAGACATT CTTCCTCTGGAATATGGTGGTGAAGAATTCTCCATGGAGGACATTTGTCAGGAATGGACA AATTTTATAATGAAGTCTGAAGATTATCTCAGCAGCATTTCTGAGAGCATTCAATGA |
GenBank Gene ID | D49488 |
GeneCard ID | None |
GenAtlas ID | TTPA |
HGNC ID | HGNC:12404 |
Chromosome Location | 8 |
Locus | 8q13.1-q13.3 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Alpha-Tocopherol |
430.717 |