Estrogen sulfotransferase

NameEstrogen sulfotransferase
Synonyms2.8.2.4 EST-1 ST1E1 STE Sulfotransferase 1E1 Sulfotransferase, estrogen-preferring
Gene NameSULT1E1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010669|Estrogen sulfotransferase
MNSELDYYEKFEEVHGILMYKDFVKYWDNVEAFQARPDDLVIATYPKSGTTWVSEIVYMI
YKEGDVEKCKEDVIFNRIPFLECRKENLMNGVKQLDEMNSPRIVKTHLPPELLPASFWEK
DCKIIYLCRNAKDVAVSFYYFFLMVAGHPNPGSFPEFVEKFMQGQVPYGSWYKHVKSWWE
KGKSPRVLFLFYEDLKEDIRKEVIKLIHFLERKPSEELVDRIIHHTSFQEMKNNPSTNYT
TLPDEIMNQKLSPFMRKGITGDWKNHFTVALNEKFDKHYEQQMKESTLKFRTEI
Number of residues294
Molecular Weight35126.185
Theoretical pI6.61
GO Classification
Functions
    estrone sulfotransferase activity
steroid binding
flavonol 3-sulfotransferase activity
sulfotransferase activity
steroid sulfotransferase activity
Processes
    estrogen metabolic process
3'-phosphoadenosine 5'-phosphosulfate metabolic process
sulfation
small molecule metabolic process
steroid metabolic process
positive regulation of fat cell differentiation
xenobiotic metabolic process
Components
    cytosol
General FunctionSulfotransferase activity
Specific FunctionSulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.
Transmembrane Regions
GenBank Protein ID488283
UniProtKB IDP49888
UniProtKB Entry NameST1E1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010670|Estrogen sulfotransferase (SULT1E1)
ATGAATTCTGAACTTGACTATTATGAAAAGTTTGAAGAAGTCCATGGGATTCTAATGTAT
AAAGATTTTGTCAAATATTGGGATAATGTGGAAGCGTTCCAGGCAAGACCAGATGATCTT
GTCATTGCCACCTACCCTAAATCTGGTACAACCTGGGTTAGTGAAATTGTGTATATGATC
TATAAAGAGGGTGATGTGGAAAAGTGCAAAGAAGATGTAATTTTTAATCGAATACCTTTC
CTGGAATGCAGAAAAGAAAACCTCATGAATGGAGTAAAACAATTAGATGAGATGAATTCT
CCTAGAATTGTGAAGACTCATTTGCCACCTGAACTTCTTCCTGCCTCATTTTGGGAAAAG
GATTGTAAGATAATCTATCTTTGCCGGAATGCAAAGGATGTGGCTGTTTCCTTTTATTAT
TTCTTTCTAATGGTGGCTGGTCATCCAAATCCTGGATCCTTTCCAGAGTTTGTGGAGAAA
TTCATGCAAGGACAGGTTCCTTATGGTTCCTGGTATAAACATGTAAAATCTTGGTGGGAA
AAGGGAAAGAGTCCACGTGTACTATTTCTTTTCTACGAAGACCTGAAAGAGGATATCAGA
AAAGAGGTGATAAAATTGATACATTTCCTGGAAAGGAAGCCATCAGAGGAGCTTGTGGAC
AGGATTATACATCATACTTCGTTCCAAGAGATGAAGAACAATCCATCCACAAATTACACA
ACACTGCCAGACGAAATTATGAACCAGAAATTGTCGCCCTTCATGAGAAAGGGAATTACA
GGAGACTGGAAAAATCACTTTACAGTAGCCCTGAATGAAAAATTTGATAAACATTATGAG
CAGCAAATGAAGGAATCTACACTGAAGTTTCGAACTGAGATCTAA
GenBank Gene IDU08098
GeneCard IDNone
GenAtlas IDSULT1E1
HGNC IDHGNC:11377
Chromosome Location4
Locus4q13.1
References
  1. Aksoy IA, Wood TC, Weinshilboum R: Human liver estrogen sulfotransferase: identification by cDNA cloning and expression. Biochem Biophys Res Commun. 1994 May 16;200(3):1621-9.[8185618 ]
  2. Her C, Aksoy IA, Kimura S, Brandriff BF, Wasmuth JJ, Weinshilboum RM: Human estrogen sulfotransferase gene (STE): cloning, structure, and chromosomal localization. Genomics. 1995 Sep 1;29(1):16-23.[8530066 ]
  3. Falany CN, Krasnykh V, Falany JL: Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase. J Steroid Biochem Mol Biol. 1995 Jun;52(6):529-39.[7779757 ]
  4. Rubin GL, Harrold AJ, Mills JA, Falany CN, Coughtrie MW: Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy. Mol Hum Reprod. 1999 Nov;5(11):995-1002.[10541560 ]
  5. Pedersen LC, Petrotchenko E, Shevtsov S, Negishi M: Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction. J Biol Chem. 2002 May 17;277(20):17928-32. Epub 2002 Mar 7.[11884392 ]
  6. Shevtsov S, Petrotchenko EV, Pedersen LC, Negishi M: Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase. Environ Health Perspect. 2003 Jun;111(7):884-8.[12782487 ]
  7. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]

Related FRC

FRCD ID Name Exact Mass Structure




F03629



3,3',4,5-Tetrachlorobiphenyl


291.98




F03632



2,2',3,3',5-Pentachlorobiphenyl


326.422




F03633



2,2',3,3',6-Pentachlorobiphenyl


326.422




F03643



2,2',3,5,6'-Pentachlorobiphenyl


326.422




F03644



2,2',3,5',6-Pentachlorobiphenyl


326.422




F03645



2,2',3,6,6'-Pentachlorobiphenyl


326.422




F03646



2,2',3,4',5'-Pentachlorobiphenyl


326.422




F03661



2,3,3',5,6-Pentachlorobiphenyl


326.422




F03649



2,2',4,4',6-Pentachlorobiphenyl


326.422




F03653



2,2',4,6,6'-Pentachlorobiphenyl


326.422




F03664



2,3,4,4',6-Pentachlorobiphenyl


326.422




F03654



2,3,3',4,4'-Pentachlorobiphenyl


326.422




F03658



2,3,3',4,6-Pentachlorobiphenyl


326.422




F03667



2,3',4,4',5-Pentachlorobiphenyl


326.422




F03668



2,3',4,4',6-Pentachlorobiphenyl


326.422




F03671



2,3,3',4',5'-Pentachlorobiphenyl


326.422




F03675



3,3',4,4',5-Pentachlorobiphenyl


326.422




F03674



2,3',4',5',6-Pentachlorobiphenyl


326.422




F03678



2,2',3,3',4,5'-Hexachlorobiphenyl


360.864




F03698



2,2',3,4',6,6'-Hexachlorobiphenyl


360.864




F03681



2,2',3,3',5,5'-Hexachlorobiphenyl


360.864




F03694



2,2',3,4',5,5'-Hexachlorobiphenyl


360.864




F03706



2,3,3',4,4',6-Hexachlorobiphenyl


360.864




F03696



2,2',3,4',5,6'-Hexachlorobiphenyl


360.864




F03699



2,2',3,5,5',6-Hexachlorobiphenyl


360.864




F03703



2,2',4,4',6,6'-Hexachlorobiphenyl


360.864




F03709



2,3,3',4,5',6-Hexachlorobiphenyl


360.864




F03705



2,3,3',4,4',5'-Hexachlorobiphenyl


360.864




F03708



2,3,3',4,5,6-Hexachlorobiphenyl


360.864




F03711



2,3,3',4',5',6-Hexachlorobiphenyl


360.864




F03712



2,3,3',5,5',6-Hexachlorobiphenyl


360.864




F03714



2,3',4,4',5,5'-Hexachlorobiphenyl


360.864




F03718



2,2',3,3',4,4',6-Heptachlorobiphenyl


395.306




F03721



2,2',3,3',4,5,6'-Heptachlorobiphenyl


395.306




F03722



2,2',3,3',4,5',6-Heptachlorobiphenyl


395.306




F03725



2,2',3,3',5,5',6-Heptachlorobiphenyl


395.306




F03723



2,2',3,3',4,6,6'-Heptachlorobiphenyl


395.306




F03726



2,2',3,3',5,6,6'-Heptachlorobiphenyl


395.306




F03728



2,2',3,4,4',5,6-Heptachlorobiphenyl


395.306




F03729



2,2',3,4,4',5,6'-Heptachlorobiphenyl


395.306




F03730



2,2',3,4,4',5',6-Heptachlorobiphenyl


395.306




F03732



2,2',3,4,5,5',6-Heptachlorobiphenyl


395.306




F03735



2,2',3,4',5,6,6'-Heptachlorobiphenyl


395.306




F03738



2,3,3',4,4',5',6-Heptachlorobiphenyl


395.306




F03741



2,2',3,3',4,4',5,6-Octachlorobiphenyl


429.748




F03739



2,3,3',4,5,5',6-Heptachlorobiphenyl


395.306




F03742



2,2',3,3',4,4',5,6'-Octachlorobiphenyl


429.748




F03745



2,2',3,3',4,5,5',6'-Octachlorobiphenyl


429.748




F03746



2,2',3,3',4,5,6,6'-Octachlorobiphenyl


429.748




F03748



2,2',3,3',5,5',6,6'-Octachlorobiphenyl


429.748




F03751



2,3,3',4,4',5,5',6-Octachlorobiphenyl


429.748




F03752



2,2',3,3',4,4',5,5',6-Nonachlorobiphenyl


464.19




F03753



2,2',3,3',4,4',5,6,6'-Nonachlorobiphenyl


464.19




F03754



2,2',3,3',4,5,5',6,6'-Nonachlorobiphenyl


464.19




F03755



Decachlorobiphenyl


498.632




F03277



Aroclor 1254


326.422




F03278



Aroclor 1260


360.864




F03289



Aroclor 1248


291.98




F03308



Aroclor 1016


257.538




F03556



2-Chlorobiphenyl


188.654




F03557



3-Chlorobiphenyl


188.654




F03558



4-Chlorobiphenyl


188.654




F03559



2,2'-Dichlorobiphenyl


223.096




F03560



2,3-Dichlorobiphenyl


223.096




F03561



2,3'-Dichlorobiphenyl


223.096




F03562



2,4-Dichlorobiphenyl


223.096




F03563



2,4'-Dichlorobiphenyl


223.096




F03564



2,5-Dichlorobiphenyl


223.096




F03565



2,6-Dichlorobiphenyl


223.096




F03566



3,3'-Dichlorobiphenyl


223.096




F03567



3,4-Dichlorobiphenyl


223.096




F03568



3,4'-Dichlorobiphenyl


223.096




F03569



3,5-Dichlorobiphenyl


223.096




F03570



4,4'-Dichlorobiphenyl


223.096




F03571



2,2',3-Trichlorobiphenyl


257.538




F03572



2,2',4-Trichlorobiphenyl


257.538




F03573



2,2',5-Trichlorobiphenyl


257.538




F03574



2,2',6-Trichlorobiphenyl


257.538




F03575



2,3,3'-Trichlorobiphenyl


257.538




F03576



2,3,4-Trichlorobiphenyl


257.538




F03577



2,3,4'-Trichlorobiphenyl


257.538




F03578



2,3,5-Trichlorobiphenyl


257.538




F03579



2,3,6-Trichlorobiphenyl


257.538




F03580



2,3',4-Trichlorobiphenyl


257.538




F03581



2,3',5-Trichlorobiphenyl


257.538




F03582



2,3',6-Trichlorobiphenyl


257.538




F03583



2,4,4'-Trichlorobiphenyl


257.538




F03584



2,4,5-Trichlorobiphenyl


257.538




F03585



2,4,6-Trichlorobiphenyl


257.538




F03586



2,4',5-Trichlorobiphenyl


257.538




F03587



2,4',6-Trichlorobiphenyl


257.538




F03588



2,3',4'-Trichlorobiphenyl


257.538




F03589



2,3',5'-Trichlorobiphenyl


257.538




F03590



3,3',4-Trichlorobiphenyl


257.538




F03591



3,4,4'-Trichlorobiphenyl


257.538




F03592



3,4,5-Tricholobiphenyl


257.538




F03593



3,4',5-Trichlorobiphenyl


257.538




F03594



2,2',3,3'-Tetrachlorobiphenyl


291.98




F03595



2,2',3,4-Tetrachlorobiphenyl


291.98




F03596



2,2',3,4'-Tetrachlorobiphenyl


291.98




F03597



2,2',3,5-Tetrachlorobiphenyl


291.98




F03600



2,2',4,5'-Tetrachlorobiphenyl


291.98




F03601



2,2',4,6-Tetrachlorobiphenyl


291.98




F03602



2,2',4,6'-Tetrachlorobiphenyl


291.98




F03603



2,2',5,5'-Tetrachlorobiphenyl


291.98




F03604



2,2',5,6'-Tetrachlorobiphenyl


291.98




F03605



2,2',6,6'-Tetrachlorobiphenyl


291.98




F03606



2,3,3',4-Tetrachlorobiphenyl


291.98




F03607



2,3,3',4'-Tetrachlorobiphenyl


291.98




F03608



2,3,3',5-Tetrachlorobiphenyl


291.98




F03609



2,3,3',5'-Tetrachlorobiphenyl


291.98




F03610



2,3,3',6-Tetrachlorobiphenyl


291.98




F03611



2,3,4,4'-Tetrachlorobiphenyl


291.98




F03612



2,3,4,5-Tetrachlorobiphenyl


291.98




F03613



2,3,4,6-Tetrachlorobiphenyl


291.98




F03614



2,3,4',5-Tetrachlorobiphenyl


291.98




F03615



2,3,4',6-Tetrachlorobiphenyl


291.98




F03616



2,3,5,6-Tetrachlorobiphenyl


291.98




F03617



2,3',4,4'-Tetrachlorobiphenyl


291.98




F03618



2,3',4,5-Tetrachlorobiphenyl


291.98




F03619



2,3',4,5'-Tetrachlorobiphenyl


291.98




F03620



2,3',4,6-Tetrachlorobiphenyl


291.98




F03621



2,3',4',5-Tetrachlorobiphenyl


291.98




F03622



2,3',4',6-Tetrachlorobiphenyl


291.98




F03623



2,3',5,5'-Tetrachlorobiphenyl


291.98




F03624



2,3',5',6-Tetrachlorobiphenyl


291.98




F03625



2,4,4',5-Tetrachlorobiphenyl


291.98




F03626



2,4,4',6-Tetrachlorobiphenyl


291.98




F03627



2,3',4',5'-Tetrachlorobiphenyl


291.98




F03628



3,3',4,4'-Tetrachlorobiphenyl


291.98




F03630



3,3',4,5'-Tetrachlorobiphenyl


291.98




F03631



3,4,4',5-Tetrachlorobiphenyl


291.98




F03634



2,2',3,4,4'-Pentachlorobiphenyl


326.422




F03635



2,2',3,4,5-Pentachlorobiphenyl


326.422




F03636



2,2',3,4,5'-Pentachlorobiphenyl


326.422




F03637



2,2',3,4,6-Pentachlorobiphenyl


326.422




F03638



2,2',3,4,6'-Pentachlorobiphenyl


326.422




F03639



2,2',3,4',5-Pentachlorobiphenyl


326.422




F03640



2,2',3,4',6-Pentachlorobiphenyl


326.422




F03641



2,2',3,5,5'-Pentachlorobiphenyl


326.422




F03642



2,2',3,5,6-Pentachlorobiphenyl


326.422




F03647



2,2',3,4',6'-Pentachlorobiphenyl


326.422




F03648



2,2',4,4',5-Pentachlorobiphenyl


326.422




F03650



2,2',4,5,5'-Pentachlorobiphenyl


326.422




F03651



2,2',4,5,6'-Pentachlorobiphenyl


326.422




F03652



2,2',4,5',6-Pentachlorobiphenyl


326.422




F03655



2,3,3',4,5-Pentachlorobiphenyl


326.422




F03656



2,3,3',4',5-Pentachlorobiphenyl


326.422




F03657



2,3,3',4,5'-Pentachlorobiphenyl


326.422




F03659



2,3,3',4',6-Pentachlorobiphenyl


326.422




F03660



2,3,3',5,5'-Pentachlorobiphenyl


326.422




F03662



2,3,3',5',6-Pentachlorobiphenyl


326.422




F03663



2,3,4,4',5-Pentachlorobiphenyl


326.422




F03665



2,3,4,5,6-Pentachlorobiphenyl


326.422




F03666



2,3,4',5,6-Pentachlorobiphenyl


326.422




F03669



2,3',4,5,5'-Pentachlorobiphenyl


326.422




F03670



2,3',4,5',6-Pentachlorobiphenyl


326.422




F03672



2,3',4,4',5'-Pentachlorobiphenyl


326.422




F03673



2,3',4',5,5'-Pentachlorobiphenyl


326.422




F03676



3,3',4,5,5'-Pentachlorobiphenyl


326.422




F03677



2,2',3,3',4,5-Hexachlorobiphenyl


360.864




F03679



2,2',3,3',4,6-Hexachlorobiphenyl


360.864




F03680



2,2',3,3',4,6'-Hexachlorobiphenyl


360.864




F03682



2,2',3,3',5,6-Hexachlorobiphenyl


360.864




F03683



2,2',3,3',5,6'-Hexachlorobiphenyl


360.864




F03684



2,2',3,3',6,6'-Hexachlorobiphenyl


360.864




F03685



2,2',3,4,4',5-Hexachlorobiphenyl


360.864




F03686



2,2',3,4,4',5'-Hexachlorobiphenyl


360.864




F03687



2,2',3,4,4',6-Hexachlorobiphenyl


360.864




F03688



2,2',3,4,4',6'-Hexachlorobiphenyl


360.864




F03689



2,2',3,4,5,5'-Hexachlorobiphenyl


360.864




F03690



2,2',3,4,5,6-Hexachlorobiphenyl


360.864




F03691



2,2',3,4,5,6'-Hexachlorobiphenyl


360.864




F03692



2,2',3,4,5',6-Hexachlorobiphenyl


360.864




F03693



2,2',3,4,6,6'-Hexachlorobiphenyl


360.864




F03695



2,2',3,4',5,6-Hexachlorobiphenyl


360.864




F03697



2,2',3,4',5',6-Hexachlorobiphenyl


360.864




F03700



2,2',3,5,6,6'-Hexachlorobiphenyl


360.864




F03701



2,2',4,4',5,5'-Hexachlorobiphenyl


360.864




F03702



2,2',4,4',5,6'-Hexachlorobiphenyl


360.864




F03704



2,3,3',4,4',5-Hexachlorobiphenyl


360.864




F03707



2,3,3',4,5,5'-Hexachlorobiphenyl


360.864




F03710



2,3,3',4',5,5'-Hexachlorobiphenyl


360.864




F03713



2,3,4,4',5,6-Hexachlorobiphenyl


360.864




F03715



2,3',4,4',5',6-Hexachlorobiphenyl


360.864




F03716



3,3',4,4',5,5'-Hexachlorobiphenyl


360.864




F03717



2,2',3,3',4,4',5-Heptachlorobiphenyl


395.306




F03719



2,2',3,3',4,5,5'-Heptachlorobiphenyl


395.306




F03720



2,2',3,3',4,5,6-Heptachlorobiphenyl


395.306




F03724



2,2',3,3',4,5',6'-Heptachlorobiphenyl


395.306




F03727



2,2',3,4,4',5,5'-Heptachlorobiphenyl


395.306




F03731



2,2',3,4,4',6,6'-Heptachlorobiphenyl


395.306




F03733



2,2',3,4,5,6,6'-Heptachlorobiphenyl


395.306




F03734



2,2',3,4',5,5',6-Heptachlorobiphenyl


395.306




F03736



2,3,3',4,4',5,5'-Heptachlorobiphenyl


395.306




F03737



2,3,3',4,4',5,6-Heptachlorobiphenyl


395.306




F03740



2,2',3,3',4,4',5,5'-Octachlorobiphenyl


429.748




F03743



2,2',3,3',4,4',6,6'-Octachlorobiphenyl


429.748




F03744



2,2',3,3',4,5,5',6-Octachlorobiphenyl


429.748




F03747



2,2',3,3',4,5',6,6'-Octachlorobiphenyl


429.748




F03749



2,2',3,4,4',5,5',6-Octachlorobiphenyl


429.748




F03750



2,2',3,4,4',5,6,6'-Octachlorobiphenyl


429.748




F03598



2,2',3,6-Tetrachlorobiphenyl


291.98




F03599



2,2',4,5-Tetrachlorobiphenyl


291.98