Serine/threonine-protein kinase Nek2

NameSerine/threonine-protein kinase Nek2
Synonyms2.7.11.1 HSPK 21 NEK2A Never in mitosis A-related kinase 2 NimA-like protein kinase 1 NimA-related protein kinase 2 NLK1
Gene NameNEK2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0007282|Serine/threonine-protein kinase Nek2
MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLR
ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL
TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP
YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY
SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS
PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE
RKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAA
QLRAQALSDIEKNYQLKSRQILGMR
Number of residues445
Molecular Weight51762.93
Theoretical pI9.25
GO Classification
Functions
    ATP binding
protein kinase activity
protein serine/threonine kinase activity
metal ion binding
protein phosphatase binding
Processes
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
mitotic nuclear division
blastocyst development
spindle assembly
positive regulation of telomerase activity
meiotic cell cycle
protein phosphorylation
positive regulation of telomere capping
negative regulation of DNA binding
G2/M transition of mitotic cell cycle
positive regulation of telomere maintenance via telomerase
mitotic sister chromatid segregation
mitotic cell cycle
regulation of attachment of spindle microtubules to kinetochore
organelle organization
centrosome separation
protein autophosphorylation
mitotic spindle assembly
negative regulation of centriole-centriole cohesion
regulation of mitotic nuclear division
cell division
regulation of mitotic centrosome separation
chromosome segregation
Components
    nucleolus
kinetochore
centrosome
protein complex
spindle pole
midbody
microtubule
condensed nuclear chromosome
cytosol
condensed chromosome kinetochore
General FunctionProtein serine/threonine kinase activity
Specific FunctionProtein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGOL1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.
Transmembrane Regions
GenBank Protein ID479171
UniProtKB IDP51955
UniProtKB Entry NameNEK2_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0021372|Serine/threonine-protein kinase Nek2 (NEK2)
ATGCCTTCCCGGGCTGAGGACTATGAAGTGTTGTACACCATTGGCACAGGCTCCTACGGC
CGCTGCCAGAAGATCCGGAGGAAGAGTGATGGCAAGATATTAGTTTGGAAAGAACTTGAC
TATGGCTCCATGACAGAAGCTGAGAAACAGATGCTTGTTTCTGAAGTGAATTTGCTTCGT
GAACTGAAACATCCAAACATCGTTCGTTACTATGATCGGATTATTGACCGGACCAATACA
ACACTGTACATTGTAATGGAATATTGTGAAGGAGGGGATCTGGCTAGTGTAATTACAAAG
GGAACCAAGGAAAGGCAATACTTAGATGAAGAGTTTGTTCTTCGAGTGATGACTCAGTTG
ACTCTGGCCCTGAAGGAATGCCACAGACGAAGTGATGGTGGTCATACCGTATTGCATCGG
GATCTGAAACCAGCCAATGTTTTCCTGGATGGCAAGCAAAACGTCAAGCTTGGAGACTTT
GGGCTAGCTAGAATATTAAACCATGACACGAGTTTTGCAAAAACATTTGTTGGCACACCT
TATTACATGTCTCCTGAACAAATGAATCGCATGTCCTACAATGAGAAATCAGATATCTGG
TCATTGGGCTGCTTGCTGTATGAGTTATGTGCATTAATGCCTCCATTTACAGCTTTTAGC
CAGAAAGAACTCGCTGGGAAAATCAGAGAAGGCAAATTCAGGCGAATTCCATACCGTTAC
TCTGATGAATTGAATGAAATTATTACGAGGATGTTAAACTTAAAGGATTACCATCGACCT
TCTGTTGAAGAAATTCTTGAGAACCCTTTAATAGCAGATTTGGTTGCAGACGAGCAAAGA
AGAAATCTTGAGAGAAGAGGGCGACAATTAGGAGAGCCAGAAAAATCGCAGGATTCCAGC
CCTGTATTGAGTGAGCTGAAACTGAAGGAAATTCAGTTACAGGAGCGAGAGCGAGCTCTC
AAAGCAAGAGAAGAAAGATTGGAGCAGAAAGAACAGGAGCTTTGTGTTCGTGAGAGACTA
GCAGAGGACAAACTGGCTAGAGCAGAAAATCTGTTGAAGAACTACAGCTTGCTAAAGGAA
CGGAAGTTCCTGTCTCTGGCAAGTAATCCAGAGTCTCACTTTGTTGCCCAGGCTGGAATG
CAGTGGTGTGATCACAGCTCAATGTAG
GenBank Gene IDZ29066
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:7745
Chromosome Location1
Locus1q32.2-q41
References
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