DNA-directed RNA polymerase II subunit RPB11-a


NameDNA-directed RNA polymerase II subunit RPB11-a
SynonymsDNA-directed RNA polymerase II subunit J-1 POLR2J1 RNA polymerase II 13.3 kDa subunit RNA polymerase II subunit B11-a
Gene NamePOLR2J
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013573|DNA-directed RNA polymerase II subunit RPB11-a
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE
Number of residues117
Molecular Weight13293.19
Theoretical pINone
GO Classification
Functions
    LRR domain binding
    DNA binding
    DNA-directed RNA polymerase activity
Processes
    transcription initiation from RNA polymerase II promoter
    transcription elongation from RNA polymerase II promoter
    somatic stem cell population maintenance
    transcription-coupled nucleotide-excision repair
    viral process
    DNA repair
    7-methylguanosine mRNA capping
    gene silencing by RNA
    nucleotide-excision repair
    mRNA splicing, via spliceosome
    transcription from RNA polymerase II promoter
    piRNA metabolic process
    positive regulation of viral transcription
    gene expression
    RNA splicing
Components
    nucleoplasm
    nucleus
    DNA-directed RNA polymerase II, core complex
General FunctionLrr domain binding
Specific FunctionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP52435
UniProtKB Entry NameRPB11_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013574|DNA-directed RNA polymerase II subunit RPB11-a (POLR2J)
ATGAACGCCCCTCCAGCCTTCGAGTCGTTCTTGCTCTTCGAGGGCGAGAAGAAGATCACC
ATTAACAAGGACACCAAGGTACCCAATGCCTGTTTATTCACCATCAACAAAGAAGACCAC
ACACTGGGAAACATCATTAAATCACAACTCCTAAAAGACCCGCAAGTGCTATTTGCTGGC
TACAAAGTCCCCCACCCCTTGGAGCACAAGATCATCATCCGAGTGCAGACCACGCCGGAC
TACAGCCCCCAGGAAGCCTTTACCAACGCCATCACCGACCTCATCAGTGAGCTGTCCCTG
CTGGAGGAGCGCTTTCGGGTGGCCATAAAAGACAAGCAGGAAGGAATTGAGTAG
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:9197
Chromosome Location7
LocusNone
References
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  5. Kershnar E, Wu SY, Chiang CM: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. J Biol Chem. 1998 Dec 18;273(51):34444-53.[9852112 ]
  6. Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C: Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb. FASEB J. 2000 May;14(7):904-12.[10783144 ]
  7. Grandemange S, Schaller S, Yamano S, Du Manoir S, Shpakovski GV, Mattei MG, Kedinger C, Vigneron M: A human RNA polymerase II subunit is encoded by a recently generated multigene family. BMC Mol Biol. 2001;2:14. Epub 2001 Nov 30.[11747469 ]
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