Cationic amino acid transporter 2

NameCationic amino acid transporter 2
SynonymsATRC2 CAT-2 CAT2 Low affinity cationic amino acid transporter 2 Solute carrier family 7 member 2
Gene NameSLC7A2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037048|Cationic amino acid transporter 2
MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA
KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI
LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLL
SFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENG
TSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCF
MAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPM
PRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLM
AYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLF
CPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAI
VLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFS
YGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF
Number of residues658
Molecular Weight71672.175
Theoretical pI7.55
GO Classification
Functions
    antiporter activity
arginine transmembrane transporter activity
high-affinity arginine transmembrane transporter activity
basic amino acid transmembrane transporter activity
high-affinity L-ornithine transmembrane transporter activity
L-lysine transmembrane transporter activity
high-affinity lysine transmembrane transporter activity
L-ornithine transmembrane transporter activity
low-affinity L-arginine transmembrane transporter activity
Processes
    macrophage activation
L-ornithine transmembrane transport
nitric oxide production involved in inflammatory response
cellular amino acid metabolic process
regulation of inflammatory response
regulation of macrophage activation
transmembrane transport
nitric oxide biosynthetic process
transport
ion transport
basic amino acid transmembrane transport
L-lysine import across plasma membrane
amino acid transport
L-arginine import across plasma membrane
L-ornithine import across plasma membrane
L-lysine transmembrane transport
Components
    integral component of plasma membrane
membrane
plasma membrane
General FunctionLow-affinity l-arginine transmembrane transporter activity
Specific FunctionFunctions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport.
Transmembrane Regions38-59 64-84 105-125 164-184 193-213 249-269 290-309 340-360 387-407 411-431 491-511 525-549 558-578 583-603
GenBank Protein ID849051
UniProtKB IDP52569
UniProtKB Entry NameCTR2_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010390|Cationic amino acid transporter 2 (SLC7A2)
ATGATTCCTTGCAGAGCCGCGCTGACCTTTGCCCGATGTCTGATCCGGAGAAAAATCGTG
ACCCTGGACAGTCTAGAAGACACCAAATTATGCCGCTGCTTATCCACCATGGACCTCATT
GCCCTGGGCGTTGGAAGCACCCTTGGGGCCGGGGTTTATGTCCTCGCTGGGGAGGTGGCC
AAGGCAGACTCGGGCCCCAGCATCGTGGTGTCCTTCCTCATTGCTGCCCTGGCTTCAGTG
ATGGCTGGCCTCTGCTATGCCGAATTTGGGGCCCGTGTTCCCAAGACGGGGTCTGCATAT
TTGTACACCTACGTGACTGTCGGAGAGCTGTGGGCCTTCATCACTGGCTGGAATCTCATT
TTATCGTATGTGATAGGTACATCAAGTGTTGCAAGAGCCTGGAGTGGCACCTTTGATGAA
CTTCTTAGCAAACAGATTGGTCAGTTTTTGAGGACATACTTCAGAATGAATTACACTGGT
CTTGCAGAATATCCCGATTTTTTTGCTGTGTGCCTTATATTACTTCTAGCAGGTCTTTTG
TCTTTTGGAGTAAAAGAGTCTGCTTGGGTGAATAAAGTCTTCACAGCTGTTAATATTCTC
GTCCTTCTGTTTGTGATGGTTGCTGGGTTTGTGAAAGGAAATGTGGCAAACTGGAAGATT
AGTGAAGAGTTTCTCAAAAATATATCAGCAAGTGCCAGAGAGCCACCTTCTGAAAACGGA
ACAAGTATCTATGGGGCTGGTGGCTTTATGCCTTATGGCTTTACGGGAACGTTGGCTGGT
GCTGCAACTTGCTTTTATGCCTTTGTGGGATTTGACTGCATTGCAACAACTGGTGAAGAA
GTTCGGAATCCCCAGAAAGCTATTCCCATTGGAATTGTGACGTCTTTGCTTGTTTGCTTT
ATGGCCTATTTTGGGGTCTCTGCAGCTTTAACACTTATGATGCCGTACTACCTCCTCGAT
GAAAAAAGCCCCCTTCCTGTAGCGTTTGAATATGTGGGATGGGGTCCTGCCAAATATGTC
GTCGCAGCTGGTTCTCTCTGCGCCTTGTCAACAAGTCTTCTTGGATCCATTTTCCCAATG
CCTCGTGTAATCTATGCTATGGCGGAGGATGGGTTGCTTTTCAAATGTCTAGCTCAAATC
AATTCCAAAACGAAGACACCAATAATTGCTACTTTATCATCGGGTGCAGTGGCAGCTTTG
ATGGCCTTTCTGTTTGACCTGAAGGCGCTTGTGGACATGATGTCCATTGGCACACTCATG
GCCTACTCTCTGGTGGCAGCCTGTGTTCTCATCCTCAGGTACCAGCCTGGCTTATCTTAC
GACCAGCCCAAATGTTCTCCTGAGAAAGATGGTCTGGGATCGTCTCCCAGGGTAACCTCG
AAGAGTGAGTCCCAGGTCACCATGCTGCAGAGACAGGGCTTCAGCATGCGGACCCTCTTC
TGCCCCTCCCTTCTGCCAACACAGCAGTCAGCTTCTCTCGTGAGCTTTCTGGTAGGATTC
CTAGCTTTCCTCGTGTTGGGCCTGAGTGTCTTGACCACTTACGGAGTTCATGCCATCACC
AGGCTGGAGGCCTGGAGCCTCGCTCTCCTCGCGCTGTTTCTTGTTCTCTTCGTTGCCATC
GTTCTCACCATCTGGAGGCAGCCCCAGAATCAGCAAAAAGTAGCCTTCATGGTTCCATTC
TTACCATTTTTGCCAGCGTTCAGCATCTTGGTGAACATTTACTTGATGGTCCAGTTAAGT
GCAGACACTTGGGTCAGATTCAGCATTTGGATGGCAATTGGCTTCCTGATTTACTTTTCT
TATGGCATTAGACACAGCCTGGAGGGTCATCTGAGAGATGAAAACAATGAAGAAGATGCT
TATCCAGACAACGTTCATGCAGCAGCAGAAGAAAAATCTGCCATTCAAGCAAATGACCAT
CACCCAAGAAATCTCAGTTCACCTTTCATATTCCATGAAAAGACAAGTGAATTCTAA
GenBank Gene IDD29990
GeneCard IDNone
GenAtlas IDSLC7A2
HGNC IDHGNC:11060
Chromosome Location8
Locus8p22-p21.3
References
  1. Hoshide R, Ikeda Y, Karashima S, Matsuura T, Komaki S, Kishino T, Niikawa N, Endo F, Matsuda I: Molecular cloning, tissue distribution, and chromosomal localization of human cationic amino acid transporter 2 (HCAT2). Genomics. 1996 Dec 1;38(2):174-8.[8954799 ]
  2. Closs EI, Graf P, Habermeier A, Cunningham JM, Forstermann U: Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties. Biochemistry. 1997 May 27;36(21):6462-8.[9174363 ]
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  5. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399.[17974005 ]
  6. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31.[18669648 ]
  7. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475.[20068231 ]
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Related FRC

FRCD ID Name Exact Mass Structure




F05301



L-Lysine


146.19




F05342



Ornithine


132.163