DNA-directed RNA polymerases I, II, and III subunit RPABC4

NameDNA-directed RNA polymerases I, II, and III subunit RPABC4
SynonymsABC10-alpha DNA-directed RNA polymerase II subunit K RNA polymerase II 7.0 kDa subunit RNA polymerases I, II, and III subunit ABC4 RPB10alpha RPB7.0
Gene NamePOLR2K
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013654|DNA-directed RNA polymerases I, II, and III subunit RPABC4
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR
Number of residues58
Molecular Weight7004.145
Theoretical pINone
GO Classification
Functions
    zinc ion binding
DNA binding
DNA-directed RNA polymerase activity
Processes
    gene silencing by RNA
transcription elongation from RNA polymerase III promoter
mRNA splicing, via spliceosome
transcription from RNA polymerase I promoter
piRNA metabolic process
transcription from RNA polymerase III promoter
innate immune response
positive regulation of viral transcription
transcription initiation from RNA polymerase I promoter
somatic stem cell population maintenance
RNA splicing
DNA repair
regulation of transcription from RNA polymerase I promoter
transcription-coupled nucleotide-excision repair
transcription elongation from RNA polymerase II promoter
viral process
nucleotide-excision repair
negative regulation of gene expression, epigenetic
transcription from RNA polymerase II promoter
regulation of gene expression, epigenetic
termination of RNA polymerase I transcription
positive regulation of type I interferon production
termination of RNA polymerase III transcription
gene expression
7-methylguanosine mRNA capping
transcription elongation from RNA polymerase I promoter
transcription initiation from RNA polymerase II promoter
Components
    cytosol
nucleoplasm
nucleus
DNA-directed RNA polymerase I complex
DNA-directed RNA polymerase III complex
DNA-directed RNA polymerase II, core complex
General FunctionZinc ion binding
Specific FunctionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP53803
UniProtKB Entry NameRPAB4_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013655|DNA-directed RNA polymerases I, II, and III subunit RPABC4 (POLR2K)
ATGGACACCCAGAAGGACGTTCAACCTCCAAAGCAGCAACCAATGATATATATCTGTGGA
GAGTGTCACACAGAAAATGAAATAAAATCTAGGGATCCAATCAGATGCAGAGAATGTGGA
TACAGAATAATGTACAAGAAAAGGACTAAAAGATTGGTCGTTTTTGATGCTCGATGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:9198
Chromosome Location8
LocusNone
References
  1. Shpakovski GV, Acker J, Wintzerith M, Lacroix JF, Thuriaux P, Vigneron M: Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae. Mol Cell Biol. 1995 Sep;15(9):4702-10.[7651387 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]

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