Sodium/potassium-transporting ATPase subunit gamma

NameSodium/potassium-transporting ATPase subunit gamma
SynonymsATP1C ATP1G1 FXYD domain-containing ion transport regulator 2 Na(+)/K(+) ATPase subunit gamma Sodium pump gamma chain
Gene NameFXYD2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000457|Sodium/potassium-transporting ATPase subunit gamma
MTGLSMDGGGSPKGDVDPFYYDYETVRNGGLIFAGLAFIVGLLILLSRRFRCGGNKKRRQ
INEDEP
Number of residues66
Molecular Weight7283.265
Theoretical pI8.47
GO Classification
Functions
    sodium
transporter activity
ion channel activity
sodium channel regulator activity
Processes
    sodium ion export from cell
transmembrane transport
ion transmembrane transport
transport
regulation of cell growth
ATP hydrolysis coupled transmembrane transport
establishment or maintenance of transmembrane electrochemical gradient
regulation of cell proliferation
potassium ion import across plasma membrane
regulation of sodium ion transmembrane transporter activity
Components
    intracellular membrane-bounded organelle
basolateral plasma membrane
sodium
plasma membrane
extracellular exosome
integral component of plasma membrane
General FunctionTransporter activity
Specific FunctionMay be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
Transmembrane Regions29-46
GenBank Protein ID1575004
UniProtKB IDP54710
UniProtKB Entry NameATNG_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0010020|Sodium/potassium-transporting ATPase subunit gamma (FXYD2)
ATGACTGGGTTGTCGATGGACGGTGGCGGCAGCCCCAAGGGGGACGTGGACCCGTTCTAC
TATGACTATGAGACCGTTCGCAATGGGGGCCTGATCTTCGCTGGACTGGCCTTCATCGTG
GGGCTCCTCATCCTCCTCAGCAGAAGATTCCGCTGTGGGGGCAATAAGAAGCGCAGGCAA
ATCAATGAAGATGAGCCGTAA
GenBank Gene IDU50743
GeneCard IDNone
GenAtlas IDFXYD2
HGNC IDHGNC:4026
Chromosome Location11
Locus11q23
References
  1. Kim JW, Lee Y, Lee IA, Kang HB, Choe YK, Choe IS: Cloning and expression of human cDNA encoding Na+, K(+)-ATPase gamma-subunit. Biochim Biophys Acta. 1997 Feb 7;1350(2):133-5.[9048881 ]
  2. Sweadner KJ, Wetzel RK, Arystarkhova E: Genomic organization of the human FXYD2 gene encoding the gamma subunit of the Na,K-ATPase. Biochem Biophys Res Commun. 2000 Dec 9;279(1):196-201.[11112438 ]
  3. Meij IC, Koenderink JB, van Bokhoven H, Assink KF, Groenestege WT, de Pont JJ, Bindels RJ, Monnens LA, van den Heuvel LP, Knoers NV: Dominant isolated renal magnesium loss is caused by misrouting of the Na(+),K(+)-ATPase gamma-subunit. Nat Genet. 2000 Nov;26(3):265-6.[11062458 ]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]

Related FRC

FRCD ID Name Exact Mass Structure




F03285



Hexachlorobutadiene


260.744




F03332



1,1-Dichloroethene


96.938




F03386



Dicofol


370.475




F03395



1,4-Dichlorobenzene


146.998




F02403



Vanadyl sulfate


165.013




F03275



Chloroform


119.369




F03276



Clofenotane


354.476




F03280



Trichloroethylene


131.38




F03281



Dieldrin


380.895




F03283



Chlordane


409.758




F03291



Toxaphene


411.774




F03293



Tetrachloroethylene


165.822




F03294



Heptachlor


373.3




F03299



3,3'-Dichlorobenzidine


253.126




F03300



Endrin


380.895




F03303



Pentachlorophenol


266.323




F03315



Methoxychlor


345.644




F03336



1,2-Dichloroethane


98.954




F03337



2,4,6-Trichlorophenol


197.439




F03341



Hexachlorobenzene


284.766




F03344



1,1,1-Trichloroethane


133.396




F03345



Ethylbenzene


106.168




F03349



Chlorobenzene


112.556




F03360



1,2,3-Trichlorobenzene


181.44




F03368



Lead-210


209.984




F03370



Chlorpyrifos


350.575




F03381



Chlordecone


490.609




F03388



1,1,2,2-Tetrachloroethane


167.838




F03396



1,1-Dichloroethane


98.954




F03400



Hexachlorocyclopentadiene


272.755




F03405



1,2-Dichlorobenzene


146.998




F03422



Vanadium


50.941




F03424



1,2,4-Trichlorobenzene


181.44




F02632



Tetraethyl lead


323.448




F03756



Methiochlor


377.766




F03757



Chlorbenzylate


325.185




F03886



1,3,5-Trichlorobenzene


181.44




F03917



Mirex


545.51




F04038



Telodrin


411.73




F04039



Isodrin


364.896




F04189



Plumbane


211.232




F04806



Oleandrin


576.727




F04913



Patulin


154.121




F04977



Rubratoxin B


518.515




F04978



Rubratoxin A


520.531




F04994



Asteltoxin


418.486




F04997



Butenolide


141.126