Oxysterols receptor LXR-beta
Name | Oxysterols receptor LXR-beta |
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Synonyms | Liver X receptor beta LXRB NER Nuclear receptor NER Nuclear receptor subfamily 1 group H member 2 Ubiquitously-expressed nuclear receptor UNR |
Gene Name | NR1H2 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0037145|Oxysterols receptor LXR-beta MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE |
Number of residues | 460 |
Molecular Weight | 50973.375 |
Theoretical pI | 7.8 |
GO Classification |
Functions
apolipoprotein A-I receptor binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding zinc ion binding steroid hormone receptor activity RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding ATPase binding RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Processes
positive regulation of transcription, DNA-templated positive regulation of triglyceride biosynthetic process positive regulation of transcription from RNA polymerase II promoter positive regulation of lipid storage regulation of cholesterol homeostasis negative regulation of proteolysis negative regulation of pinocytosis positive regulation of cellular protein metabolic process negative regulation of transcription, DNA-templated positive regulation of cholesterol transport negative regulation of transcription from RNA polymerase II promoter retinoic acid receptor signaling pathway positive regulation of high-density lipoprotein particle assembly cellular lipid metabolic process positive regulation of pancreatic juice secretion cholesterol homeostasis negative regulation of lipid transport gene expression positive regulation of secretion of lysosomal enzymes negative regulation of cholesterol storage positive regulation of fatty acid biosynthetic process transcription initiation from RNA polymerase II promoter negative regulation of macrophage derived foam cell differentiation positive regulation of lipoprotein lipase activity positive regulation of cholesterol efflux negative regulation of interferon-gamma-mediated signaling pathway Components
cytoplasm nucleus nucleoplasm |
General Function | Zinc ion binding |
Specific Function | Nuclear receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). |
Transmembrane Regions | |
GenBank Protein ID | 641962 |
UniProtKB ID | P55055 |
UniProtKB Entry Name | NR1H2_HUMAN |
Cellular Location | Nucleus |
Gene sequence | >lcl|BSEQ0021844|Oxysterols receptor LXR-beta (NR1H2) ATGTCCTCTCCTACCACGAGTTCCCTGGATACCCCCCTGCCTGGAAATGGCCCCCCTCAG CCTGGCGCCCCTTCTTCTTCACCCACTGTAAAGGAGGAGGGTCCGGAGCCGTGGCCCGGG GGTCCGGACCCTGATGTCCCAGGCACTGATGAGGCCAGCTCAGCCTGCAGCACAGACTGG GGCGTCCTTTCTGAAGAACAGATCCGGAAGAAGAAGATTCGGAAACAACAGCAGCAGGAG TCACAGTCACAGTCGCAGTCACCTGTGGGGCCGCAGGGCAGCAGCAGCTCAGCCTCTGGG CCTGGGGCTTCCCCTGGTGGATCTGAGGCAGGCAGCCAGGGCTCCGGGGAAGGCGAGGGT GTCCAGCTAACAGCGGCTCAAGAACTAATGATCCAGCAGTTGGTGGCGGCCCAACTGCAG TGCAACAAACGCTCCTTCTCCGACCAGCCCAAAGTCACGCCCTGGCCCCTGGGCGCAGAC CCCCAGTCCCGAGATGCCCGCCAGCAACGCTTTGCCCACTTCACGGAGCTGGCCATCATC TCAGTCCAGGAGATCGTGGACTTCGCTAAGCAAGTGCCTGGTTTCCTGCAGCTGGGCCGG GAGGACCAGATCGCCCTCCTGAAGGCATCCACTATCGAGATCATGCTGCTAGAGACAGCC AGGCGCTACAACCACGAGACAGAGTGTATCACCTTCTTGAAGGACTTCACCTACAGCAAG GACGACTTCCACCGTGCAGGCCTGCAGGTGGAGTTCATCAACCCCATCTTCGAGTTCTCG CGGGCCATGCGGCGGCTGGGCCTGGACGACGCTGAGTACGCCCTGCTCATCGCCATCAAC ATCTTCTCGGCCGACCGGCCCAACGTGCAGGAGCCGGGCCGCGTGGAGGCGTTGCAGCAG CCCTACGTGGAGGCGCTGCTGTCCTACACGCGCATCAAGAGGCCGCAGGACCAGCTGCGC TTCCCGCGCATGCTCATGAAGCTGGTGAGCCTGCGCACGCTGAGCTCTGTGCACTCGGAG CAGGTCTTCGCCTTGCGGCTCCAGGACAAGAAGCTGCCGCCTCTGCTGTCGGAGATCTGG GACGTCCACGAGTGA |
GenBank Gene ID | U07132 |
GeneCard ID | None |
GenAtlas ID | NR1H2 |
HGNC ID | HGNC:7965 |
Chromosome Location | 19 |
Locus | 19q13.3-19q13.3 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Tebufenpyrad |
333.86 |
||
Tebupirimfos |
318.372 |
||
Androstenedione |
286.4 |
||
Isazofos |
313.737 |
||
Forskolin |
410.507 |
||
Ethion |
384.5 |