Oxysterols receptor LXR-beta


NameOxysterols receptor LXR-beta
SynonymsLiver X receptor beta LXRB NER Nuclear receptor NER Nuclear receptor subfamily 1 group H member 2 Ubiquitously-expressed nuclear receptor UNR
Gene NameNR1H2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037145|Oxysterols receptor LXR-beta
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Number of residues460
Molecular Weight50973.375
Theoretical pI7.8
GO Classification
Functions
    apolipoprotein A-I receptor binding
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
    zinc ion binding
    steroid hormone receptor activity
    RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding
    ATPase binding
    RNA polymerase II core promoter proximal region sequence-specific DNA binding
    DNA binding
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Processes
    positive regulation of transcription, DNA-templated
    positive regulation of triglyceride biosynthetic process
    positive regulation of transcription from RNA polymerase II promoter
    positive regulation of lipid storage
    regulation of cholesterol homeostasis
    negative regulation of proteolysis
    negative regulation of pinocytosis
    positive regulation of cellular protein metabolic process
    negative regulation of transcription, DNA-templated
    positive regulation of cholesterol transport
    negative regulation of transcription from RNA polymerase II promoter
    retinoic acid receptor signaling pathway
    positive regulation of high-density lipoprotein particle assembly
    cellular lipid metabolic process
    positive regulation of pancreatic juice secretion
    cholesterol homeostasis
    negative regulation of lipid transport
    gene expression
    positive regulation of secretion of lysosomal enzymes
    negative regulation of cholesterol storage
    positive regulation of fatty acid biosynthetic process
    transcription initiation from RNA polymerase II promoter
    negative regulation of macrophage derived foam cell differentiation
    positive regulation of lipoprotein lipase activity
    positive regulation of cholesterol efflux
    negative regulation of interferon-gamma-mediated signaling pathway
Components
    cytoplasm
    nucleus
    nucleoplasm
General FunctionZinc ion binding
Specific FunctionNuclear receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920).
Transmembrane Regions
GenBank Protein ID641962
UniProtKB IDP55055
UniProtKB Entry NameNR1H2_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0021844|Oxysterols receptor LXR-beta (NR1H2)
ATGTCCTCTCCTACCACGAGTTCCCTGGATACCCCCCTGCCTGGAAATGGCCCCCCTCAG
CCTGGCGCCCCTTCTTCTTCACCCACTGTAAAGGAGGAGGGTCCGGAGCCGTGGCCCGGG
GGTCCGGACCCTGATGTCCCAGGCACTGATGAGGCCAGCTCAGCCTGCAGCACAGACTGG
GGCGTCCTTTCTGAAGAACAGATCCGGAAGAAGAAGATTCGGAAACAACAGCAGCAGGAG
TCACAGTCACAGTCGCAGTCACCTGTGGGGCCGCAGGGCAGCAGCAGCTCAGCCTCTGGG
CCTGGGGCTTCCCCTGGTGGATCTGAGGCAGGCAGCCAGGGCTCCGGGGAAGGCGAGGGT
GTCCAGCTAACAGCGGCTCAAGAACTAATGATCCAGCAGTTGGTGGCGGCCCAACTGCAG
TGCAACAAACGCTCCTTCTCCGACCAGCCCAAAGTCACGCCCTGGCCCCTGGGCGCAGAC
CCCCAGTCCCGAGATGCCCGCCAGCAACGCTTTGCCCACTTCACGGAGCTGGCCATCATC
TCAGTCCAGGAGATCGTGGACTTCGCTAAGCAAGTGCCTGGTTTCCTGCAGCTGGGCCGG
GAGGACCAGATCGCCCTCCTGAAGGCATCCACTATCGAGATCATGCTGCTAGAGACAGCC
AGGCGCTACAACCACGAGACAGAGTGTATCACCTTCTTGAAGGACTTCACCTACAGCAAG
GACGACTTCCACCGTGCAGGCCTGCAGGTGGAGTTCATCAACCCCATCTTCGAGTTCTCG
CGGGCCATGCGGCGGCTGGGCCTGGACGACGCTGAGTACGCCCTGCTCATCGCCATCAAC
ATCTTCTCGGCCGACCGGCCCAACGTGCAGGAGCCGGGCCGCGTGGAGGCGTTGCAGCAG
CCCTACGTGGAGGCGCTGCTGTCCTACACGCGCATCAAGAGGCCGCAGGACCAGCTGCGC
TTCCCGCGCATGCTCATGAAGCTGGTGAGCCTGCGCACGCTGAGCTCTGTGCACTCGGAG
CAGGTCTTCGCCTTGCGGCTCCAGGACAAGAAGCTGCCGCCTCTGCTGTCGGAGATCTGG
GACGTCCACGAGTGA
GenBank Gene IDU07132
GeneCard IDNone
GenAtlas IDNR1H2
HGNC IDHGNC:7965
Chromosome Location19
Locus19q13.3-19q13.3
References
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  4. Sakurabashi A, Wada-Hiraike O, Hirano M, Fu H, Isono W, Fukuda T, Morita Y, Tanikawa M, Miyamoto Y, Oda K, Kawana K, Osuga Y, Fujii T: CCAR2 negatively regulates nuclear receptor LXRalpha by competing with SIRT1 deacetylase. J Steroid Biochem Mol Biol. 2015 May;149:80-8. doi: 10.1016/j.jsbmb.2015.02.001. Epub 2015 Feb 3.[25661920 ]
  5. Farnegardh M, Bonn T, Sun S, Ljunggren J, Ahola H, Wilhelmsson A, Gustafsson JA, Carlquist M: The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands. J Biol Chem. 2003 Oct 3;278(40):38821-8. Epub 2003 Jun 20.[12819202 ]
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