ATP-binding cassette sub-family E member 1

NameATP-binding cassette sub-family E member 1
Synonyms2'-5'-oligoadenylate-binding protein HuHP68 Ribonuclease 4 inhibitor RLI RNase L inhibitor RNASEL1 RNASELI RNS4I
Gene NameABCE1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013219|ATP-binding cassette sub-family E member 1
MADKLTRIAIVNHDKCKPKKCRQECKKSCPVVRMGKLCIEVTPQSKIAWISETLCIGCGI
CIKKCPFGALSIVNLPSNLEKETTHRYCANAFKLHRLPIPRPGEVLGLVGTNGIGKSTAL
KILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILEDDLKAIIKPQYVDQIPKAA
KGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMF
DEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVT
MPFSVREGINIFLDGYVPTENLRFRDASLVFKVAETANEEEVKKMCMYKYPGMKKKMGEF
ELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISPKS
TGSVRQLLHEKIRDAYTHPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVALALCLGKPA
DVYLIDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDFIMATYLADRVIVFDGVPS
KNTVANSPQTLLAGMNKFLSQLEITFRRDPNNYRPRINKLNSIKDVEQKKSGNYFFLDD
Number of residues599
Molecular Weight67313.73
Theoretical pINone
GO Classification
Functions
    ribonuclease inhibitor activity
ATP binding
ATPase activity
Processes
    transmembrane transport
response to virus
viral process
RNA catabolic process
negative regulation of catalytic activity
Components
    mitochondrial matrix
cytoplasm
mitochondrion
membrane
General FunctionRibonuclease inhibitor activity
Specific FunctionAntagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP61221
UniProtKB Entry NameABCE1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013220|ATP-binding cassette sub-family E member 1 (ABCE1)
ATGGCAGACAAGTTAACGAGAATTGCTATTGTCAACCATGACAAATGTAAACCTAAGAAA
TGTCGACAGGAATGCAAAAAGAGTTGTCCTGTAGTTCGAATGGGAAAATTATGCATAGAG
GTTACACCCCAGAGCAAAATAGCATGGATTTCCGAAACTCTTTGTATTGGTTGTGGTATC
TGTATTAAGAAATGCCCCTTTGGCGCCTTATCAATTGTCAATCTACCAAGCAACTTGGAA
AAAGAAACCACACATCGATATTGTGCCAATGCCTTCAAACTTCACAGGTTGCCTATCCCT
CGTCCAGGTGAAGTTTTGGGATTAGTTGGAACTAATGGTATTGGAAAGTCAACTGCTTTA
AAAATTTTAGCAGGAAAACAAAAGCCAAACCTTGGAAAGTACGATGATCCTCCTGACTGG
CAGGAGATTTTGACTTATTTCCGTGGATCTGAATTACAAAATTACTTTACAAAGATTCTA
GAAGATGACCTAAAAGCCATCATCAAACCTCAATATGTAGACCAGATTCCTAAGGCTGCA
AAGGGGACAGTGGGATCTATTTTGGACCGAAAAGATGAAACAAAGACACAGGCAATTGTA
TGTCAGCAGCTTGATTTAACCCACCTAAAAGAACGAAATGTTGAAGATCTTTCAGGAGGA
GAGTTGCAGAGATTTGCTTGTGCTGTCGTTTGCATACAGAAAGCTGATATTTTCATGTTT
GATGAGCCTTCTAGTTACCTAGATGTCAAGCAGCGTTTAAAGGCTGCTATTACTATACGA
TCTCTAATAAATCCAGATAGATATATCATTGTGGTGGAACATGATCTAAGTGTATTAGAC
TATCTCTCCGACTTCATCTGCTGTTTATATGGTGTACCAAGCGCCTATGGAGTTGTCACT
ATGCCTTTTAGTGTAAGAGAAGGCATAAACATTTTTTTGGATGGCTATGTTCCAACAGAA
AACTTGAGATTCAGAGATGCATCACTTGTTTTTAAAGTGGCTGAGACAGCAAATGAAGAA
GAAGTTAAAAAGATGTGTATGTATAAATATCCAGGAATGAAGAAAAAAATGGGAGAATTT
GAGCTAGCAATTGTAGCTGGAGAGTTTACAGATTCTGAAATTATGGTGATGCTGGGGGAA
AATGGAACGGGTAAAACGACATTTATCAGAATGCTTGCTGGAAGACTTAAACCTGATGAA
GGAGGAGAAGTACCAGTTCTAAATGTCAGTTATAAGCCACAGAAAATTAGTCCCAAATCA
ACTGGAAGTGTTCGCCAGTTACTACATGAAAAGATAAGAGATGCTTATACTCACCCACAA
TTTGTGACCGATGTAATGAAGCCTCTGCAAATTGAAAACATCATTGATCAAGAGGTGCAG
ACATTATCTGGTGGTGAACTACAGCGAGTAGCTTTAGCCCTTTGCTTGGGCAAACCTGCT
GATGTCTATTTAATTGATGAACCATCTGCATATTTGGATTCTGAGCAAAGACTGATGGCA
GCTCGAGTTGTCAAACGTTTCATACTCCATGCAAAAAAGACAGCCTTTGTTGTGGAACAT
GACTTCATCATGGCCACCTATCTAGCGGATCGCGTCATCGTTTTTGATGGTGTTCCATCT
AAGAACACAGTTGCAAACAGTCCTCAAACCCTTTTGGCTGGCATGAATAAATTTTTGTCT
CAGCTTGAAATTACATTCAGAAGAGATCCAAACAACTATAGGCCACGAATAAACAAACTT
AATTCAATTAAGGATGTAGAACAAAAGAAGAGTGGAAACTACTTTTTCTTGGATGATTAG
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:69
Chromosome Location4
LocusNone
References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]
  2. Le Roy F, Bisbal C, Silhol M, Martinand C, Lebleu B, Salehzada T: The 2-5A/RNase L/RNase L inhibitor (RLI) [correction of (RNI)] pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells. J Biol Chem. 2001 Dec 21;276(51):48473-82. Epub 2001 Oct 3.[11585831 ]
  3. Bisbal C, Martinand C, Silhol M, Lebleu B, Salehzada T: Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway. J Biol Chem. 1995 Jun 2;270(22):13308-17.[7539425 ]
  4. Aubry F, Mattei MG, Barque JP, Galibert F: Chromosomal localization and expression pattern of the RNase L inhibitor gene. FEBS Lett. 1996 Feb 26;381(1-2):135-9.[8641422 ]
  5. Martinand C, Salehzada T, Silhol M, Lebleu B, Bisbal C: RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis-virus-(EMCV)-infected cells. Eur J Biochem. 1998 Jun 1;254(2):248-55.[9660177 ]
  6. Martinand C, Montavon C, Salehzada T, Silhol M, Lebleu B, Bisbal C: RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells. J Virol. 1999 Jan;73(1):290-6.[9847332 ]
  7. Zimmerman C, Klein KC, Kiser PK, Singh AR, Firestein BL, Riba SC, Lingappa JR: Identification of a host protein essential for assembly of immature HIV-1 capsids. Nature. 2002 Jan 3;415(6867):88-92.[11780123 ]
  8. Dooher JE, Lingappa JR: Conservation of a stepwise, energy-sensitive pathway involving HP68 for assembly of primate lentivirus capsids in cells. J Virol. 2004 Feb;78(4):1645-56.[14747530 ]
  9. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17.[21269460 ]
  10. Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8.[25944712 ]
  11. Bunger MK, Cargile BJ, Sevinsky JR, Deyanova E, Yates NA, Hendrickson RC, Stephenson JL Jr: Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data. J Proteome Res. 2007 Jun;6(6):2331-40. Epub 2007 May 9.[17488105 ]

Related FRC

FRCD ID Name Exact Mass Structure




F05174



Thallium


239.83