Arginase-2, mitochondrial
Name | Arginase-2, mitochondrial |
---|---|
Synonyms | 3.5.3.1 Kidney-type arginase Non-hepatic arginase Type II arginase |
Gene Name | ARG2 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0010535|Arginase-2, mitochondrial MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSS LGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDH SLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG FSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIG KRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQ LATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI |
Number of residues | 354 |
Molecular Weight | 38577.515 |
Theoretical pI | 6.45 |
GO Classification |
Functions
arginase activity metal ion binding Processes
cellular nitrogen compound metabolic process small molecule metabolic process polyamine metabolic process urea cycle nitric oxide biosynthetic process ureteric bud development arginine metabolic process striated muscle contraction Components
mitochondrion mitochondrial matrix |
General Function | Metal ion binding |
Specific Function | May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders. |
Transmembrane Regions | |
GenBank Protein ID | 1694633 |
UniProtKB ID | P78540 |
UniProtKB Entry Name | ARGI2_HUMAN |
Cellular Location | Mitochondrion |
Gene sequence | >lcl|BSEQ0010536|Arginase-2, mitochondrial (ARG2) ATGTCCCTAAGGGGCAGCCTCTCGCGTCTCCTCCAGACGCGAGTGCATTCCATCCTGAAG AAATCCGTCCACTCCGTGGCTGTGATAGGAGCCCCGTTCTCACAAGGGCAGAAAAGAAAA GGAGTGGAGCATGGTCCCGCTGCCATAAGAGAAGCTGGCTTGATGAAAAGGCTCTCCAGT TTGGGCTGCCACCTAAAAGACTTTGGAGATTTGAGTTTTACTCCAGTCCCCAAAGATGAT CTCTACAACAACCTGATAGTGAATCCACGCTCAGTGGGTCTTGCCAACCAGGAACTGGCT GAGGTGGTTAGCAGAGCTGTGTCAGATGGCTACAGCTGTGTCACACTGGGAGGAGACCAC AGCCTGGCAATCGGTACCATTAGTGGCCATGCCCGACACTGCCCAGACCTTTGTGTTGTC TGGGTTGATGCCCATGCTGACATCAACACACCCCTTACCACTTCATCAGGAAATCTCCAT GGACAGCCAGTTTCATTTCTCCTCAGAGAACTACAGGATAAGGTACCACAACTCCCAGGA TTTTCCTGGATCAAACCTTGTATCTCTTCTGCAAGTATTGTGTATATTGGTCTGAGAGAC GTGGACCCTCCTGAACATTTTATTTTAAAGAACTATGATATCCAGTATTTTTCCATGAGA GATATTGATCGACTTGGTATCCAGAAGGTCATGGAACGAACATTTGATCTGCTGATTGGC AAGAGACAAAGACCAATCCATTTGAGTTTTGATATTGATGCATTTGACCCTACACTGGCT CCAGCCACAGGAACTCCTGTTGTCGGGGGACTAACCTATCGAGAAGGCATGTATATTGCT GAGGAAATACACAATACAGGGTTGCTATCAGCACTGGATCTTGTTGAAGTCAATCCTCAG TTGGCCACCTCAGAGGAAGAGGCGAAGACTACAGCTAACCTGGCAGTAGATGTGATTGCT TCAAGCTTTGGTCAGACAAGAGAAGGAGGGCATATTGTCTATGACCAACTTCCTACTCCC AGTTCACCAGATGAATCAGAAAATCAAGCACGTGTGAGAATTTAG |
GenBank Gene ID | D86724 |
GeneCard ID | None |
GenAtlas ID | ARG2 |
HGNC ID | HGNC:664 |
Chromosome Location | 14 |
Locus | 14q24.1-q24.3 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
L-Arginine |
174.204 |
||
Ornithine |
132.163 |