Transcription factor E2F1

NameTranscription factor E2F1
SynonymsE2F-1 PBR3 pRB-binding protein E2F-1 RBAP-1 RBBP-3 RBBP3 Retinoblastoma-associated protein 1 Retinoblastoma-binding protein 3
Gene NameE2F1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009214|Transcription factor E2F1
MALAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISAAQDASAPPAPTGPAAPAAGPCD
PDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVK
SPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLI
AKKSKNHIQWLGSHTTVGVGGRLEGLTQDLRQLQESEQQLDHLMNICTTQLRLLSEDTDS
QRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAVDSSENFQISLKSKQGPIDVFLCPE
ETVGGISPGKTPSQEVTSEEENRATDSATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLS
RMGSLRAPVDEDRLSPLVAADSLLEHVREDFSGLLPEEFISLSPPHEALDYHFGLEEGEG
IRDLFDCDFGDLTPLDF
Number of residues437
Molecular Weight46919.28
Theoretical pINone
GO Classification
Functions
    transcription factor binding
sequence-specific DNA binding
core promoter binding
transcription factor activity, sequence-specific DNA binding
DNA binding
Processes
    cellular response to xenobiotic stimulus
transcription, DNA-templated
cellular response to nerve growth factor stimulus
negative regulation of fat cell proliferation
positive regulation of gene expression
cellular response to fatty acid
G1/S transition of mitotic cell cycle
positive regulation of fibroblast proliferation
intrinsic apoptotic signaling pathway in response to DNA damage
lens fiber cell apoptotic process
forebrain development
regulation of transcription, DNA-templated
mRNA stabilization
intrinsic apoptotic signaling pathway
DNA damage checkpoint
positive regulation of transcription, DNA-templated
negative regulation of transcription involved in G1/S transition of mitotic cell cycle
regulation of G1/S transition of mitotic cell cycle
apoptotic process
negative regulation of DNA binding
positive regulation of transcription from RNA polymerase II promoter
Notch signaling pathway
negative regulation of fat cell differentiation
negative regulation of transcription from RNA polymerase II promoter
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
anoikis
mitotic cell cycle
spermatogenesis
programmed cell death
intrinsic apoptotic signaling pathway by p53 class mediator
cellular response to hypoxia
negative regulation of transcription, DNA-templated
Components
    nucleoplasm
Rb-E2F complex
nuclear chromatin
cytoplasm
nucleus
General FunctionTranscription factor binding
Specific FunctionTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812).
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ01094
UniProtKB Entry NameE2F1_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0020866|Transcription factor E2F1 (E2F1)
ATGGCCTTGGCCGGGGCCCCTGCGGGCGGCCCATGCGCGCCGGCGCTGGAGGCCCTGCTC
GGGGCCGGCGCGCTGCGGCTGCTCGACTCCTCGCAGATCGTCATCATCTCCGCCGCGCAG
GACGCCAGCGCCCCGCCGGCTCCCACCGGCCCCGCGGCGCCCGCCGCCGGCCCCTGCGAC
CCTGACCTGCTGCTCTTCGCCACACCGCAGGCGCCCCGGCCCACACCCAGTGCGCCGCGG
CCCGCGCTCGGCCGCCCGCCGGTGAAGCGGAGGCTGGACCTGGAAACTGACCATCAGTAC
CTGGCCGAGAGCAGTGGGCCAGCTCGGGGCAGAGGCCGCCATCCAGGAAAAGGTGTGAAA
TCCCCGGGGGAGAAGTCACGCTATGAGACCTCACTGAATCTGACCACCAAGCGCTTCCTG
GAGCTGCTGAGCCACTCGGCTGACGGTGTCGTCGACCTGAACTGGGCTGCCGAGGTGCTG
AAGGTGCAGAAGCGGCGCATCTATGACATCACCAACGTCCTTGAGGGCATCCAGCTCATT
GCCAAGAAGTCCAAGAACCACATCCAGTGGCTGGGCAGCCACACCACAGTGGGCGTCGGC
GGACGGCTTGAGGGGTTGACCCAGGACCTCCGACAGCTGCAGGAGAGCGAGCAGCAGCTG
GACCACCTGATGAATATCTGTACTACGCAGCTGCGCCTGCTCTCCGAGGACACTGACAGC
CAGCGCCTGGCCTACGTGACGTGTCAGGACCTTCGTAGCATTGCAGACCCTGCAGAGCAG
ATGGTTATGGTGATCAAAGCCCCTCCTGAGACCCAGCTCCAAGCCGTGGACTCTTCGGAG
AACTTTCAGATCTCCCTTAAGAGCAAACAAGGCCCGATCGATGTTTTCCTGTGCCCTGAG
GAGACCGTAGGTGGGATCAGCCCTGGGAAGACCCCATCCCAGGAGGTCACTTCTGAGGAG
GAGAACAGGGCCACTGACTCTGCCACCATAGTGTCACCACCACCATCATCTCCCCCCTCA
TCCCTCACCACAGATCCCAGCCAGTCTCTACTCAGCCTGGAGCAAGAACCGCTGTTGTCC
CGGATGGGCAGCCTGCGGGCTCCCGTGGACGAGGACCGCCTGTCCCCGCTGGTGGCGGCC
GACTCGCTCCTGGAGCATGTGCGGGAGGACTTCTCCGGCCTCCTCCCTGAGGAGTTCATC
AGCCTTTCCCCACCCCACGAGGCCCTCGACTACCACTTCGGCCTCGAGGAGGGCGAGGGC
ATCAGAGACCTCTTCGACTGTGACTTTGGGGACCTCACCCCCCTGGATTTCTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:3113
Chromosome Location20
LocusNone
References
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