Dual specificity mitogen-activated protein kinase kinase 1
| Name | Dual specificity mitogen-activated protein kinase kinase 1 |
|---|---|
| Synonyms | 2.7.12.2 ERK activator kinase 1 MAP kinase kinase 1 MAPK/ERK kinase 1 MEK 1 MEK1 PRKMK1 |
| Gene Name | MAP2K1 |
| Organism | Human |
| Amino acid sequence | >lcl|BSEQ0001734|Dual specificity mitogen-activated protein kinase kinase 1 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV |
| Number of residues | 393 |
| Molecular Weight | 43438.65 |
| Theoretical pI | 6.61 |
| GO Classification |
Functions
protein serine/threonine kinase activity protein N-terminus binding receptor signaling protein tyrosine phosphatase activity protein serine/threonine/tyrosine kinase activity protein C-terminus binding protein tyrosine kinase activity MAP kinase kinase activity protein serine/threonine kinase activator activity ATP binding protein kinase activity Processes
positive regulation of cell migration positive regulation of transcription elongation from RNA polymerase II promoter stress-activated MAPK cascade TRIF-dependent toll-like receptor signaling pathway activation of MAPKK activity placenta blood vessel development toll-like receptor 10 signaling pathway positive regulation of GTPase activity mitophagy in response to mitochondrial depolarization fibroblast growth factor receptor signaling pathway toll-like receptor 2 signaling pathway movement of cell or subcellular component insulin receptor signaling pathway epithelial cell proliferation involved in lung morphogenesis toll-like receptor 3 signaling pathway cellular senescence MAPK cascade Golgi inheritance toll-like receptor 4 signaling pathway response to axon injury keratinocyte differentiation melanosome transport negative regulation of cell proliferation ERK1 and ERK2 cascade toll-like receptor 5 signaling pathway response to oxidative stress activation of MAPK activity axon guidance positive regulation of Ras protein signal transduction labyrinthine layer development negative regulation of homotypic cell-cell adhesion neurotrophin TRK receptor signaling pathway positive regulation of protein serine/threonine kinase activity positive regulation of gene expression toll-like receptor 9 signaling pathway cell cycle arrest epidermal growth factor receptor signaling pathway regulation of stress-activated MAPK cascade vesicle transport along microtubule Ras protein signal transduction MyD88-dependent toll-like receptor signaling pathway protein heterooligomerization toll-like receptor signaling pathway small GTPase mediated signal transduction innate immune response regulation of axon regeneration signal transduction vascular endothelial growth factor receptor signaling pathway MyD88-independent toll-like receptor signaling pathway negative regulation of gene expression toll-like receptor TLR1 cell motility mitotic nuclear division regulation of early endosome to late endosome transport regulation of vascular smooth muscle contraction toll-like receptor TLR6 chemotaxis Fc-epsilon receptor signaling pathway positive regulation of axonogenesis regulation of Golgi inheritance response to glucocorticoid trachea formation Components
perikaryon cytosol early endosome microtubule extracellular exosome nucleus perinuclear region of cytoplasm microtubule organizing center endoplasmic reticulum focal adhesion cell cortex dendrite cytoplasm plasma membrane cytoplasm mitochondrion late endosome Golgi apparatus axon |
| General Function | Receptor signaling protein tyrosine phosphatase activity |
| Specific Function | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. |
| Transmembrane Regions | |
| GenBank Protein ID | 188569 |
| UniProtKB ID | Q02750 |
| UniProtKB Entry Name | MP2K1_HUMAN |
| Cellular Location | Cytoplasm |
| Gene sequence | >lcl|BSEQ0016235|Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) ATGCCCAAGAAGAAGCCGACGCCCATCCAGCTGAACCCGGCCCCCGACGGCTCTGCAGTT AACGGGACCAGCTCTGCGGAGACCAACTTGGAGGCCTTGCAGAAGAAGCTGGAGGAGCTA GAGCTTGATGAGCAGCAGCGAAAGCGCCTTGAGGCCTTTCTTACCCAGAAGCAGAAGGTG GGAGAACTGAAGGATGACGACTTTGAGAAGATCAGTGAGCTGGGGGCTGGCAATGGCGGT GTGGTGTTCAAGGTCTCCCACAAGCCTTCTGGCCTGGTCATGGCCAGAAAGCTAATTCAT CTGGAGATCAAACCCGCAATCCGGAACCAGATCATAAGGGAGCTGCAGGTTCTGCATGAG TGCAACTCTCCGTACATCGTGGGCTTCTATGGTGCGTTCTACAGCGATGGCGAGATCAGT ATCTGCATGGAGCACATGGATGGAGGTTCTCTGGATCAAGTCCTGAAGAAAGCTGGAAGA ATTCCTGAACAAATTTTAGGAAAAGTTAGCATTGCTGTAATAAAAGGCCTGACATATCTG AGGGAGAAGCACAAGATCATGCACAGAGATGTCAAGCCCTCCAACATCCTAGTCAACTCC CGTGGGGAGATCAAGCTCTGTGACTTTGGGGTCAGCGGGCAGCTCATCGACTCCATGGCC AACTCCTTCGTGGGCACAAGGTCCTACATGTCGCCAGAAAGACTCCAGGGGACTCATTAC TCTGTGCAGTCAGACATCTGGAGCATGGGACTGTCTCTGGTAGAGATGGCGGTTGGGAGG TATCCCATCCCTCCTCCAGATGCCAAGGAGCTGGAGCTGATGTTTGGGTGCCAGGTGGAA GGAGATGCGGCTGAGACCCCACCCAGGCCAAGGACCCCCGGGAGGCCCCTTAGCTCATAC GGAATGGACAGCCGACCTCCCATGGCAATTTTTGAGTTGTTGGATTACATAGTCAACGAG CCTCCTCCAAAACTGCCCAGTGGAGTGTTCAGTCTGGAATTTCAAGATTTTGTGAATAAA TGCTTAATAAAAAACCCCGCAGAGAGAGCAGATTTGAAGCAACTCATGGTTCATGCTTTT ATCAAGAGATCTGATGCTGAGGAAGTGGATTTTGCAGGTTGGCTCTGCTCCACCATCGGC CTTAACCAGCCCAGCACACCAACCCATGCTGCTGGCGTCTAA |
| GenBank Gene ID | L05624 |
| GeneCard ID | None |
| GenAtlas ID | MAP2K1 |
| HGNC ID | HGNC:6840 |
| Chromosome Location | 15 |
| Locus | 15q22.1-q22.33 |
| References |
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Related FRC
| FRCD ID | Name | Exact Mass | Structure |
|---|---|---|---|
1,4-Naphthoquinone |
158.156 |