Urokinase plasminogen activator surface receptor


NameUrokinase plasminogen activator surface receptor
SynonymsMO3 Monocyte activation antigen Mo3 U-PAR UPAR
Gene NamePLAUR
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001430|Urokinase plasminogen activator surface receptor
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEEL
ELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISC
GSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNG
FHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGP
MNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDV
QYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
Number of residues335
Molecular Weight36977.62
Theoretical pI6.64
GO Classification
Functions
    receptor activity
    receptor binding
    protein domain specific binding
    urokinase plasminogen activator receptor activity
    enzyme binding
Processes
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
    C-terminal protein lipidation
    negative regulation of intrinsic apoptotic signaling pathway
    urokinase plasminogen activator signaling pathway
    positive regulation of protein phosphorylation
    positive regulation of DNA binding
    signal transduction
    positive regulation of epidermal growth factor receptor signaling pathway
    blood coagulation
    positive regulation of release of cytochrome c from mitochondria
    cellular protein metabolic process
    negative regulation of apoptotic process
    post-translational protein modification
    fibrinolysis
    regulation of proteolysis
    chemotaxis
    movement of cell or subcellular component
    attachment of GPI anchor to protein
Components
    extracellular exosome
    integral component of plasma membrane
    endoplasmic reticulum lumen
    anchored component of membrane
    plasma membrane
    extrinsic component of membrane
    endoplasmic reticulum membrane
    invadopodium membrane
    focal adhesion
    integral component of membrane
General FunctionUrokinase plasminogen activator receptor activity
Specific FunctionActs as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Transmembrane Regions
GenBank Protein ID37605
UniProtKB IDQ03405
UniProtKB Entry NameUPAR_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0016188|Urokinase plasminogen activator surface receptor (PLAUR)
ATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACACCTGCGTCCCAGCCTCT
TGGGGCCTGCGGTGCATGCAGTGTAAGACCAACGGGGATTGCCGTGTGGAAGAGTGCGCC
CTGGGACAGGACCTCTGCAGGACCACGATCGTGCGCTTGTGGGAAGAAGGAGAAGAGCTG
GAGCTGGTGGAGAAAAGCTGTACCCACTCAGAGAAGACCAACAGGACCCTGAGCTATCGG
ACTGGCTTGAAGATCACCAGCCTTACCGAGGTTGTGTGTGGGTTAGACTTGTGCAACCAG
GGCAACTCTGGCCGGGCTGTCACCTATTCCCGAAGCCGTTACCTCGAATGCATTTCCTGT
GGCTCATCAGACATGAGCTGTGAGAGGGGCCGGCACCAGAGCCTGCAGTGCCGCAGCCCT
GAAGAACAGTGCCTGGATGTGGTGACCCACTGGATCCAGGAAGGTGAAGAAGGGCGTCCA
AAGGATGACCGCCACCTCCGTGGCTGTGGCTACCTTCCCGGCTGCCCGGGCTCCAATGGT
TTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAACACCACCAAATGCAACGAG
GGCCCAATCCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAG
GGGAACAGCACCCATGGATGCTCCTCTGAAGAGACTTTCCTCATTGACTGCCGAGGCCCC
ATGAATCAATGTCTGGTAGCCACCGGCACTCACGAACGCTCACTCTGGGGAAGCTGGTTG
CCATGTAAAAGTACTACTGCCCTGAGACCACCATGCTGTGAGGAAGCCCAAGCTACTCAT
GTATAA
GenBank Gene IDX51675
GeneCard IDNone
GenAtlas IDPLAUR
HGNC IDHGNC:9053
Chromosome Location19
Locus19q13
References
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FRCD ID Name Exact Mass Structure



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Chlorsulfuron




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Cyhalofop-butyl




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Cyprodinil




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Daminozide




160.173



Dichloran




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Dimethenamid




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Ethalfluralin




333.267



Fluroxypyr




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Napropamide




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