Protein kinase C zeta type

NameProtein kinase C zeta type
Synonyms2.7.11.13 nPKC-zeta PKC2
Gene NamePRKCZ
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008674|Protein kinase C zeta type
MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKW
VDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGAR
RWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC
RKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDG
IKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTE
KHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEI
CIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAP
EILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF
LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT
DDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
Number of residues592
Molecular Weight67659.335
Theoretical pINone
GO Classification
Functions
    metal ion binding
potassium channel regulator activity
protein kinase C activity
ATP binding
protein kinase activity
protein serine/threonine kinase activity
insulin receptor substrate binding
Processes
    activation of protein kinase B activity
negative regulation of peptidyl-tyrosine phosphorylation
positive regulation of interleukin-5 secretion
insulin receptor signaling pathway
positive regulation of insulin receptor signaling pathway
inflammatory response
vesicle transport along microtubule
positive regulation of T-helper 2 cell cytokine production
negative regulation of apoptotic process
membrane depolarization
establishment of cell polarity
positive regulation of T-helper 2 cell differentiation
negative regulation of protein complex assembly
membrane hyperpolarization
positive regulation of ERK1 and ERK2 cascade
protein kinase C signaling
platelet activation
positive regulation of excitatory postsynaptic potential
protein phosphorylation
transforming growth factor beta receptor signaling pathway
positive regulation of interleukin-13 secretion
actin cytoskeleton reorganization
vascular endothelial growth factor receptor signaling pathway
microtubule cytoskeleton organization
protein heterooligomerization
long-term synaptic potentiation
positive regulation of cell proliferation
signal transduction
positive regulation of NF-kappaB transcription factor activity
protein localization to plasma membrane
positive regulation of interleukin-4 production
positive regulation of cell-matrix adhesion
peptidyl-serine phosphorylation
activation of phospholipase D activity
negative regulation of insulin receptor signaling pathway
long-term memory
neuron projection extension
blood coagulation
negative regulation of hydrolase activity
positive regulation of interleukin-10 secretion
cell migration
positive regulation of glucose import
Components
    nuclear envelope
plasma membrane
nuclear matrix
microtubule organizing center
bicellular tight junction
axon hillock
cytoplasm
vesicle
membrane
apical cortex
cell junction
cell-cell junction
filamentous actin
myelin sheath abaxonal region
cytosol
membrane raft
extracellular exosome
endosome
perinuclear region of cytoplasm
cell leading edge
apical plasma membrane
General FunctionProtein serine/threonine kinase activity
Specific FunctionCalcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Necessary and sufficient for LTP maintenance in hippocampal CA1 pyramidal cells. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis. Phosphorylates VAMP2 in vitro (PubMed:17313651).
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ05513
UniProtKB Entry NameKPCZ_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013346|Protein kinase C zeta type (PRKCZ)
ATGGATTCTGTCATGCCTTCCCAAGAGCCTCCAGTAGACGACAAGAACGAGGACGCCGAC
CTTCCTTCCGAGGAGACAGATGGAATTGCTTACATTTCCTCATCCCGGAAGCATGACAGC
ATTAAAGACGACTCGGAGGACCTTAAGCCAGTTATCGATGGGATGGATGGAATCAAAATC
TCTCAGGGGCTTGGGCTGCAGGACTTTGACCTAATCAGAGTCATCGGGCGCGGGAGCTAC
GCCAAGGTTCTCCTGGTGCGGTTGAAGAAGAATGACCAAATTTACGCCATGAAAGTGGTG
AAGAAAGAGCTGGTGCATGATGACGAGGATATTGACTGGGTACAGACAGAGAAGCACGTG
TTTGAGCAGGCATCCAGCAACCCCTTCCTGGTCGGATTACACTCCTGCTTCCAGACGACA
AGTCGGTTGTTCCTGGTCATTGAGTACGTCAACGGCGGGGACCTGATGTTCCACATGCAG
AGGCAGAGGAAGCTCCCTGAGGAGCACGCCAGGTTCTACGCGGCCGAGATCTGCATCGCC
CTCAACTTCCTGCACGAGAGGGGGATCATCTACAGGGACCTGAAGCTGGACAACGTCCTC
CTGGATGCGGACGGGCACATCAAGCTCACAGACTACGGCATGTGCAAGGAAGGCCTGGGC
CCTGGTGACACAACGAGCACTTTCTGCGGAACCCCGAATTACATCGCCCCCGAAATCCTG
CGGGGAGAGGAGTACGGGTTCAGCGTGGACTGGTGGGCGCTGGGAGTCCTCATGTTTGAG
ATGATGGCCGGGCGCTCCCCGTTCGACATCATCACCGACAACCCGGACATGAACACAGAG
GACTACCTTTTCCAAGTGATCCTGGAGAAGCCCATCCGGATCCCCCGGTTCCTGTCCGTC
AAAGCCTCCCATGTTTTAAAAGGATTTTTAAATAAGGACCCCAAAGAGAGGCTCGGCTGC
CGGCCACAGACTGGATTTTCTGACATCAAGTCCCACGCGTTCTTCCGCAGCATAGACTGG
GACTTGCTGGAGAAGAAGCAGGCGCTCCCTCCATTCCAGCCACAGATCACAGACGACTAC
GGTCTGGACAACTTTGACACACAGTTCACCAGCGAGCCCGTGCAGCTGACCCCAGACGAT
GAGGATGCCATAAAGAGGATCGACCAGTCAGAGTTCGAAGGCTTTGAGTATATCAACCCA
TTATTGCTGTCCACCGAGGAGTCGGTGTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:9412
Chromosome Location1
LocusNone
References
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