Bile salt sulfotransferase


NameBile salt sulfotransferase
Synonyms2.8.2.14 Dehydroepiandrosterone sulfotransferase DHEA-ST HST Hydroxysteroid Sulfotransferase ST2 ST2A1 ST2A3 STD Sulfotransferase 2A1
Gene NameSULT2A1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010624|Bile salt sulfotransferase
MSDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSK
GDAKWIQSVPIWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLM
RNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKNFL
LLSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNYSLLSVDYVV
DKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRELFPWE
Number of residues285
Molecular Weight33779.57
Theoretical pI5.76
GO Classification
Functions
    bile-salt sulfotransferase activity
    sulfotransferase activity
Processes
    steroid metabolic process
    cellular lipid metabolic process
    xenobiotic metabolic process
    3'-phosphoadenosine 5'-phosphosulfate metabolic process
    bile acid catabolic process
    sulfation
    digestion
    small molecule metabolic process
Components
    cytosol
    cytoplasm
General FunctionSulfotransferase activity
Specific FunctionSulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.
Transmembrane Regions
GenBank Protein ID306702
UniProtKB IDQ06520
UniProtKB Entry NameST2A1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010625|Bile salt sulfotransferase (SULT2A1)
ATGTCGGACGATTTCTTATGGTTTGAAGGCATAGCTTTCCCTACTATGGGTTTCAGATCC
GAAACCTTAAGAAAAGTACGTGATGAGTTCGTGATAAGGGATGAAGATGTAATAATATTG
ACTTACCCCAAATCAGGAACAAACTGGTTGGCTGAGATTCTCTGCCTGATGCACTCCAAG
GGGGATGCCAAGTGGATCCAATCTGTGCCCATCTGGGAGCGATCACCCTGGGTAGAGAGT
GAGATTGGGTATACAGCACTCAGTGAAACGGAGAGTCCACGTTTATTCTCCTCCCACCTC
CCCATCCAGTTATTCCCCAAGTCTTTCTTCAGTTCCAAGGCCAAGGTGATTTATCTCATG
AGAAATCCCAGAGATGTTTTGGTGTCTGGTTATTTTTTCTGGAAAAACATGAAGTTTATT
AAGAAACCAAAGTCATGGGAAGAATATTTTGAATGGTTTTGTCAAGGAACTGTGCTATAT
GGGTCATGGTTTGACCACATTCATGGCTGGATGCCCATGAGAGAGGAGAAAAACTTCCTG
TTACTGAGTTATGAGGAGCTGAAACAGGACACAGGAAGAACCATAGAGAAGATCTGTCAA
TTCCTGGGAAAGACGTTAGAACCCGAAGAACTGAACTTAATTCTCAAGAACAGCTCCTTT
CAGAGCATGAAAGAAAACAAGATGTCCAATTATTCCCTCCTGAGTGTTGATTATGTAGTG
GACAAAGCACAACTTCTGAGAAAAGGTGTATCTGGGGACTGGAAAAATCACTTCACAGTG
GCCCAAGCTGAAGACTTTGATAAATTGTTCCAAGAGAAGATGGCAGATCTTCCTCGAGAG
CTGTTCCCATGGGAATAA
GenBank Gene IDL20000
GeneCard IDNone
GenAtlas IDSULT2A1
HGNC IDHGNC:11458
Chromosome Location19
Locus19q13.3
References
  1. Otterness DM, Wieben ED, Wood TC, Watson WG, Madden BJ, McCormick DJ, Weinshilboum RM: Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA. Mol Pharmacol. 1992 May;41(5):865-72.[1588921 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]
  3. Comer KA, Falany JL, Falany CN: Cloning and expression of human liver dehydroepiandrosterone sulphotransferase. Biochem J. 1993 Jan 1;289 ( Pt 1):233-40.[7678732 ]
  4. Forbes KJ, Hagen M, Glatt H, Hume R, Coughtrie MW: Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme. Mol Cell Endocrinol. 1995 Jul;112(1):53-60.[7589785 ]
  5. Luu-The V, Dufort I, Paquet N, Reimnitz G, Labrie F: Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene. DNA Cell Biol. 1995 Jun;14(6):511-8.[7598806 ]
  6. Otterness DM, Her C, Aksoy S, Kimura S, Wieben ED, Weinshilboum RM: Human dehydroepiandrosterone sulfotransferase gene: molecular cloning and structural characterization. DNA Cell Biol. 1995 Apr;14(4):331-41.[7710689 ]
  7. Kong AN, Yang L, Ma M, Tao D, Bjornsson TD: Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of sulfotransferase from human liver. Biochem Biophys Res Commun. 1992 Aug 31;187(1):448-54.[1520333 ]
  8. Radominska A, Comer KA, Zimniak P, Falany J, Iscan M, Falany CN: Human liver steroid sulphotransferase sulphates bile acids. Biochem J. 1990 Dec 15;272(3):597-604.[2268288 ]
  9. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17.[21269460 ]
  10. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22.[24275569 ]
  11. Pedersen LC, Petrotchenko EV, Negishi M: Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase. FEBS Lett. 2000 Jun 9;475(1):61-4.[10854859 ]
  12. Rehse PH, Zhou M, Lin SX: Crystal structure of human dehydroepiandrosterone sulphotransferase in complex with substrate. Biochem J. 2002 May 15;364(Pt 1):165-71.[11988089 ]
  13. Chang HJ, Shi R, Rehse P, Lin SX: Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex. J Biol Chem. 2004 Jan 23;279(4):2689-96. Epub 2003 Oct 21.[14573603 ]

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FRCD ID Name Exact Mass Structure



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Cyclanilide




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Fludioxonil




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Prallethrin




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Diazinon




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Parathion




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Dicofol




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Ethoprop




242.332



Rotenone




394.423



Alachlor




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Acetochlor




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Carbaril




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Butachlor




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Metolachlor




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Bifenazate




300.358



Diclosulam




406.213



Ametryn




227.33



Benfluralin




335.283



Bensulide




397.503



Boscalid




343.207



Bromacil




261.119



Buprofezin




305.44



Clofentezine




303.146



Cyanazine




240.695



Cyprodinil




225.295



Ethalfluralin




333.267



Etoxazole




359.417



Fenamidone




311.403



Fluazinam




465.089



Flutolanil




323.315



Indoxacarb




527.837



Iprodione




330.165



Isoxaben




332.4



Lactofen




461.774



Methidathion




302.318



Thiazopyr




396.376



Norflurazon




303.669



Oxadiazon




345.22



Prochloraz




376.662



Prometryn




241.357



Pyridaben




364.932



Propargite




350.473



Propiconazole




342.22



Pyraclostrobin




387.82



Spiroxamine




297.483



Tebupirimfos




318.372



Tebufenpyrad




333.86



Butralin




295.339



Coumaphos




362.761



Cyazofamid




324.783



Cyproconazole




291.779



Diazoxon




288.284



Diphenylamine




169.227



Dithiopyr




401.41



Ethofumesate




286.342



Diuron




233.092



Famoxadone




374.396



Linuron




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Maneb




265.284



Oryzalin




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Quintozene




295.321



Triticonazole




317.817



Triadimefon




293.751



Triadimenol




295.767