C-X-C motif chemokine 9

NameC-X-C motif chemokine 9
SynonymsCMK Gamma-interferon-induced monokine HuMIG MIG Monokine induced by interferon-gamma SCYB9 Small-inducible cytokine B9
Gene NameCXCL9
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017719|C-X-C motif chemokine 9
MKKSGVLFLLGIILLVLIGVQGTPVVRKGRCSCISTNQGTIHLQSLKDLKQFAPSPSCEK
IEIIATLKNGVQTCLNPDSADVKELIKKWEKQVSQKKKQKNGKKHQKKKVLKVRKSQRSR
QKKTT
Number of residues125
Molecular Weight14018.72
Theoretical pINone
GO Classification
Functions
    cytokine activity
chemokine activity
CXCR3 chemokine receptor binding
Processes
    G-protein coupled receptor signaling pathway
positive regulation of myoblast fusion
positive regulation of release of sequestered calcium ion into cytosol
T cell chemotaxis
defense response
response to lipopolysaccharide
immune response
cellular defense response
positive regulation of cAMP-mediated signaling
chemokine-mediated signaling pathway
inflammatory response
defense response to virus
cell-cell signaling
positive regulation of myoblast differentiation
chemotaxis
regulation of cell proliferation
positive regulation of cAMP metabolic process
signal transduction
positive regulation of leukocyte chemotaxis
Components
    extracellular space
external side of plasma membrane
extracellular region
General FunctionCytokine activity
Specific FunctionCytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ07325
UniProtKB Entry NameCXCL9_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0017720|C-X-C motif chemokine 9 (CXCL9)
ATGAAGAAAAGTGGTGTTCTTTTCCTCTTGGGCATCATCTTGCTGGTTCTGATTGGAGTG
CAAGGAACCCCAGTAGTGAGAAAGGGTCGCTGTTCCTGCATCAGCACCAACCAAGGGACT
ATCCACCTACAATCCTTGAAAGACCTTAAACAATTTGCCCCAAGCCCTTCCTGCGAGAAA
ATTGAAATCATTGCTACACTGAAGAATGGAGTTCAAACATGTCTAAACCCAGATTCAGCA
GATGTGAAGGAACTGATTAAAAAGTGGGAGAAACAGGTCAGCCAAAAGAAAAAGCAAAAG
AATGGGAAAAAACATCAAAAAAAGAAAGTTCTGAAAGTTCGAAAATCTCAACGTTCTCGT
CAAAAGAAGACTACATAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:7098
Chromosome Location4
LocusNone
References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]
  2. Farber JM: HuMig: a new human member of the chemokine family of cytokines. Biochem Biophys Res Commun. 1993 Apr 15;192(1):223-30.[8476424 ]
  3. Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R: Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). J Invest Dermatol. 1999 May;112(5):716-22.[10233762 ]

Related FRC

FRCD ID Name Exact Mass Structure




F04333



Chlorothalonil


265.902




F04384



Permethrin


391.288




F05053



Dazomet


162.269




F05054



Dichloran


207.01




F05036



Butafenacil


474.817




F05037



Captan


300.578




F05063



Ethephon


144.491




F05071



Fluazinam


465.089




F05094



Lactofen


461.774




F05113



Niclosamide


327.117




F05130



Pyraclostrobin


387.82




F05131



Pyridaben


364.932




F05132



Pyriproxyfen


321.376




F05137



Spiroxamine


297.483




F05399



Clopyralid


191.995




F05437



Pyrimethanil


199.257




F05445



Thiram


240.416




F05452



Zoxamide


336.637




F05390



Bentazon


240.277




F03447



(±)-Naled


380.778




F04025



Propoxur


209.245