Sodium channel subunit beta-1


NameSodium channel subunit beta-1
Synonyms
Gene NameSCN1B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0006988|Sodium channel subunit beta-1
MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFR
QKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYE
CHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIY
CYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE
Number of residues218
Molecular Weight24706.955
Theoretical pI4.56
GO Classification
Functions
    voltage-gated sodium channel activity involved in cardiac muscle cell action potential
    sodium channel regulator activity
    voltage-gated sodium channel activity involved in Purkinje myocyte action potential
    voltage-gated sodium channel activity
    sodium channel inhibitor activity
Processes
    corticospinal neuron axon guidance
    sodium ion transmembrane transport
    regulation of atrial cardiac muscle cell membrane depolarization
    regulation of heart rate by cardiac conduction
    regulation of ventricular cardiac muscle cell membrane repolarization
    cell adhesion
    regulation of sodium ion transmembrane transporter activity
    cardiac muscle cell action potential involved in contraction
    positive regulation of neuron projection development
    cardiac muscle contraction
    membrane depolarization
    neuronal action potential propagation
    synaptic transmission
    membrane depolarization during cardiac muscle cell action potential
    locomotion
    membrane depolarization during Purkinje myocyte cell action potential
    cardiac conduction
    axon guidance
    positive regulation of sodium ion transport
Components
    intercalated disc
    T-tubule
    extracellular region
    node of Ranvier
    voltage-gated sodium channel complex
General FunctionVoltage-gated sodium channel activity involved in purkinje myocyte action potential
Specific FunctionCrucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.Isoform 2: Cell adhesion molecule that plays a critical role in neuronal migration and pathfinding during brain development. Stimulates neurite outgrowth.
Transmembrane Regions161-182
GenBank Protein ID307415
UniProtKB IDQ07699
UniProtKB Entry NameSCN1B_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0019451|Sodium channel subunit beta-1 (SCN1B)
ATGGGGAGGCTGCTGGCCTTAGTGGTCGGCGCGGCACTGGTGTCCTCAGCCTGCGGGGGC
TGCGTGGAGGTGGACTCGGAGACCGAGGCCGTGTATGGGATGACCTTCAAAATTCTTTGC
ATCTCCTGCAAGCGCCGCAGCGAGACCAACGCTGAGACCTTCACCGAGTGGACCTTCCGC
CAGAAGGGCACTGAGGAGTTTGTCAAGATCCTGCGCTATGAGAATGAGGTGTTGCAGCTG
GAGGAGGATGAGCGCTTCGAGGGCCGCGTGGTGTGGAATGGCAGCCGGGGCACCAAAGAC
CTGCAGGATCTGTCTATCTTCATCACCAATGTCACCTACAACCACTCGGGCGACTACGAG
TGCCACGTCTACCGCCTGCTCTTCTTCGAAAACTACGAGCACAACACCAGCGTCGTCAAG
AAGATCCACATTGAGGTAGTGGACAAAGCCAACAGAGACATGGCATCCATCGTGTCTGAG
ATCATGATGTATGTGCTCATTGTGGTGTTGACCATATGGCTCGTGGCAGAGATGATTTAC
TGCTACAAGAAGATCGCTGCCGCCACGGAGACTGCTGCACAGGAGAATGCCTCGGAATAC
CTGGCCATCACCTCTGAAAGCAAAGAGAACTGCACGGGCGTCCAGGTGGCCGAATAG
GenBank Gene IDL10338
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:10586
Chromosome Location19
Locus19q13.1
References
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  2. McClatchey AI, Cannon SC, Slaugenhaupt SA, Gusella JF: The cloning and expression of a sodium channel beta 1-subunit cDNA from human brain. Hum Mol Genet. 1993 Jun;2(6):745-9.[8394762 ]
  3. Makita N, Bennett PB Jr, George AL Jr: Voltage-gated Na+ channel beta 1 subunit mRNA expressed in adult human skeletal muscle, heart, and brain is encoded by a single gene. J Biol Chem. 1994 Mar 11;269(10):7571-8.[8125980 ]
  4. Qin N, D'Andrea MR, Lubin ML, Shafaee N, Codd EE, Correa AM: Molecular cloning and functional expression of the human sodium channel beta1B subunit, a novel splicing variant of the beta1 subunit. Eur J Biochem. 2003 Dec;270(23):4762-70.[14622265 ]
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Related FRC


FRCD ID Name Exact Mass Structure



Bioresmethrin




338.447



Tralomethrin




665.014



Cinerin I




316.441



Jasmolin I




330.468



Pyrethrin I




328.452



Ciguatoxin 1




1111.329



Ciguatoxin 2




1095.33



54-Deoxyciguatoxin




1095.33



Delphinine




599.721



Aconitine




645.746



Toluene




92.141



Cismethrin




338.447



Cyhalothrin




449.854



Fenpropathrin




349.43



Permethrin




391.288



Robustoxin




4848.664



Grayanotoxin I




1098.734



Clofenotane




354.476



Methoxychlor




345.644



Dicofol




370.475



Pyrethrum




372.461



Allethrin




302.414



Phenothrin




350.458



Resmethrin




338.447



Tetramethrin




331.412



Cyfluthrin




434.288



Cyphenothrin




375.468



Cypermethrin




416.298



Deltamethrin




505.206



Fenvalerate




419.905



Fluvalinate




502.918