Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

NameSerine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Synonyms3.1.3.16 Calmodulin-dependent calcineurin A subunit alpha isoform CALNA CAM-PRP catalytic subunit CNA
Gene NamePPP3CA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008060|Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESV
ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYV
DRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMD
AFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG
NEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFP
SLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEK
VTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESV
LTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRIN
ERMPPRRDAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ
Number of residues521
Molecular Weight58687.27
Theoretical pI5.66
GO Classification
Functions
    calcium ion binding
protein dimerization activity
calmodulin-dependent protein phosphatase activity
enzyme binding
protein serine/threonine phosphatase activity
drug binding
calmodulin binding
Processes
    excitatory postsynaptic potential
cardiac muscle hypertrophy in response to stress
dephosphorylation
multicellular organismal response to stress
negative regulation of chromatin binding
cellular response to drug
cellular response to glucose stimulus
negative regulation of dendrite morphogenesis
G1/S transition of mitotic cell cycle
positive regulation of sequence-specific DNA binding transcription factor activity
T cell activation
innate immune response
protein dephosphorylation
protein import into nucleus
Fc-epsilon receptor signaling pathway
positive regulation of cardiac muscle hypertrophy in response to stress
positive regulation of transcription from RNA polymerase II promoter
calcineurin-NFAT signaling cascade
modulation of synaptic transmission
stimulatory C-type lectin receptor signaling pathway
positive regulation of NFAT protein import into nucleus
skeletal muscle fiber development
response to amphetamine
negative regulation of insulin secretion
calcium ion transport
transition between fast and slow fiber
response to calcium ion
Components
    sarcolemma
Z disc
cytosol
nucleoplasm
calcineurin complex
cytoplasm
mitochondrion
General FunctionProtein serine/threonine phosphatase activity
Specific FunctionCalcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.
Transmembrane Regions
GenBank Protein ID306477
UniProtKB IDQ08209
UniProtKB Entry NamePP2BA_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0019537|Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (PPP3CA)
ATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCGACGACCGACAGGGTGGTGAAAGCT
GTTCCATTTCCTCCAAGTCACCGGCTTACAGCAAAAGAAGTGTTTGATAATGATGGAAAA
CCTCGTGTGGATATCTTAAAGGCGCATCTTATGAAGGAGGGAAGGCTGGAAGAGAGTGTT
GCATTGAGAATAATAACAGAGGGTGCATCAATTCTTCGACAGGAAAAAAATTTGCTGGAT
ATTGATGCGCCAGTCACTGTTTGTGGGGACATTCATGGACAATTCTTTGATTTGATGAAG
CTCTTTGAAGTCGGGGGATCTCCTGCCAACACTCGCTACCTCTTCTTAGGGGACTATGTT
GACAGAGGGTACTTCAGTATTGAATGTGTGCTGTATTTGTGGGCCTTGAAAATTCTCTAC
CCCAAAACACTGTTTTTACTTCGTGGAAATCATGAATGTAGACATCTAACAGAGTATTTC
ACATTTAAACAAGAATGTAAAATAAAGTATTCAGAACGCGTATATGATGCCTGTATGGAT
GCCTTTGACTGCCTTCCCCTGGCTGCCCTGATGAACCAACAGTTCCTGTGTGTGCATGGT
GGTTTGTCTCCAGAGATTAACACTTTAGATGATATCAGAAAATTAGACCGATTCAAAGAA
CCACCTGCATATGGACCTATGTGTGATATCCTGTGGTCAGACCCCCTGGAAGATTTTGGA
AATGAGAAGACTCAGGAACATTTCACTCACAACACAGTCAGGGGGTGTTCATACTTCTAC
AGTTACCCGGCTGTATGTGAATTCTTACAGCACAATAACTTGTTATCTATACTCCGAGCC
CACGAAGCCCAAGATGCAGGGTACCGCATGTACAGGAAAAGCCAAACAACAGGCTTCCCT
TCTCTAATTACAATTTTTTCAGCACCAAATTACTTAGATGTATACAATAACAAAGCTGCA
GTATTGAAGTATGAGAACAATGTTATGAATATCAGGCAATTCAACTGTTCTCCTCATCCA
TACTGGCTTCCAAATTTCATGGATGTTTTTACTTGGTCCCTTCCATTTGTTGGGGAAAAA
GTGACTGAGATGCTGGTAAATGTCCTCAACATCTGCTCAGATGATGAACTAGGGTCAGAA
GAAGATGGATTTGATGGTGCAACAGCTGCAGCCCGGAAAGAGGTGATAAGGAACAAGATC
CGAGCAATAGGCAAAATGGCCAGAGTGTTCTCAGTGCTCAGAGAAGAGAGTGAGAGTGTG
CTGACGCTGAAAGGCTTGACCCCAACTGGCATGCTCCCCAGCGGAGTACTTTCTGGAGGG
AAGCAAACCCTGCAAAGCGCTACTGTTGAGGCTATTGAGGCTGATGAAGCTATCAAAGGA
TTTTCACCACAACATAAGATCACTAGCTTCGAGGAAGCCAAGGGCTTAGACCGAATTAAT
GAGAGGATGCCGCCTCGCAGAGATGCCATGCCCTCTGACGCCAACCTTAACTCCATCAAC
AAGGCTCTCACCTCAGAGACTAACGGCACGGACAGCAATGGCAGTAATAGCAGCAATATT
CAGTGA
GenBank Gene IDL14778
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:9314
Chromosome Location4
Locus4q21-q24
References
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