Oxysterols receptor LXR-alpha
Name | Oxysterols receptor LXR-alpha |
---|---|
Synonyms | Liver X receptor alpha LXRA Nuclear receptor subfamily 1 group H member 3 |
Gene Name | NR1H3 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0007253|Oxysterols receptor LXR-alpha MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV HSEQVFALRLQDKKLPPLLSEIWDVHE |
Number of residues | 447 |
Molecular Weight | 50395.34 |
Theoretical pI | 7.72 |
GO Classification |
Functions
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding sequence-specific DNA binding transcription coactivator activity sterol response element binding transcription regulatory region DNA binding zinc ion binding steroid hormone receptor activity DNA binding cholesterol binding Processes
positive regulation of toll-like receptor 4 signaling pathway cellular response to lipopolysaccharide regulation of circadian rhythm cholesterol homeostasis response to progesterone gene expression sterol homeostasis negative regulation of cholesterol storage lipid homeostasis transcription initiation from RNA polymerase II promoter positive regulation of lipoprotein lipase activity negative regulation of macrophage derived foam cell differentiation negative regulation of interferon-gamma-mediated signaling pathway positive regulation of cholesterol efflux positive regulation of transcription, DNA-templated regulation of cholesterol homeostasis positive regulation of triglyceride biosynthetic process negative regulation of macrophage activation negative regulation of pancreatic juice secretion positive regulation of transcription from RNA polymerase II promoter triglyceride homeostasis positive regulation of receptor biosynthetic process negative regulation of pinocytosis positive regulation of cellular protein metabolic process apoptotic cell clearance negative regulation of lipid transport negative regulation of secretion of lysosomal enzymes negative regulation of inflammatory response positive regulation of cholesterol homeostasis positive regulation of cholesterol transport negative regulation of transcription from RNA polymerase II promoter intracellular receptor signaling pathway positive regulation of fatty acid biosynthetic process Components
RNA polymerase II transcription factor complex nucleoplasm nuclear chromatin nucleus receptor complex |
General Function | Zinc ion binding |
Specific Function | Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). |
Transmembrane Regions | |
GenBank Protein ID | 726513 |
UniProtKB ID | Q13133 |
UniProtKB Entry Name | NR1H3_HUMAN |
Cellular Location | Nucleus |
Gene sequence | >lcl|BSEQ0019469|Oxysterols receptor LXR-alpha (NR1H3) ATGTCCTTGTGGCTGGGGGCCCCTGTGCCTGACATTCCTCCTGACTCTGCGGTGGAGCTG TGGAAGCCAGGCGCACAGGATGCAAGCAGCCAGGCCCAGGGAGGCAGCAGCTGCATCCTC AGAGAGGAAGCCAGGATGCCCCACTCTGCTGGGGGTACTGCAGGGGTGGGGCTGGAGGCT GCAGAGCCCACAGCCCTGCTCACCAGGGCAGAGCCCCCTTCAGAACCCACAGAGATCCGT CCACAAAAGCGGAAAAAGGGGCCAGCCCCCAAAATGCTGGGGAACGAGCTATGCAGCGTG TGTGGGGACAAGGCCTCGGGCTTCCACTACAATGTTCTGAGCTGCGAGGGCTGCAAGGGA TTCTTCCGCCGCAGCGTCATCAAGGGAGCGCACTACATCTGCCACAGTGGCGGCCACTGC CCCATGGACACCTACATGCGTCGCAAGTGCCAGGAGTGTCGGCTTCGCAAATGCCGTCAG GCTGGCATGCGGGAGGAGTGTGTCCTGTCAGAAGAACAGATCCGCCTGAAGAAACTGAAG CGGCAAGAGGAGGAACAGGCTCATGCCACATCCTTGCCCCCCAGGGCTTCCTCACCCCCC CAAATCCTGCCCCAGCTCAGCCCGGAACAACTGGGCATGATCGAGAAGCTCGTCGCTGCC CAGCAACAGTGTAACCGGCGCTCCTTTTCTGACCGGCTTCGAGTCACGGTGATGCTTCTG GAGACATCTCGGAGGTACAACCCTGGGAGTGAGAGTATCACCTTCCTCAAGGATTTCAGT TATAACCGGGAAGACTTTGCCAAAGCAGGGCTGCAAGTGGAATTCATCAACCCCATCTTC GAGTTCTCCAGGGCCATGAATGAGCTGCAACTCAATGATGCCGAGTTTGCCTTGCTCATT GCTATCAGCATCTTCTCTGCAGACCGGCCCAACGTGCAGGACCAGCTCCAGGTAGAGAGG CTGCAGCACACATATGTGGAAGCCCTGCATGCCTACGTCTCCATCCACCATCCCCATGAC CGACTGATGTTCCCACGGATGCTAATGAAACTGGTGAGCCTCCGGACCCTGAGCAGCGTC CACTCAGAGCAAGTGTTTGCACTGCGTCTGCAGGACAAAAAGCTCCCACCGCTGCTCTCT GAGATCTGGGATGTGCACGAATGA |
GenBank Gene ID | U22662 |
GeneCard ID | None |
GenAtlas ID | |
HGNC ID | HGNC:7966 |
Chromosome Location | 11 |
Locus | 11p11.2 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Genistein |
270.24 |
||
Safrole |
162.188 |
||
Cholesterol |
386.664 |
||
Isazofos |
313.737 |
||
Tebufenpyrad |
333.86 |
||
Tebupirimfos |
318.372 |
||
2,4,6-Trichlorophenol |
197.439 |
||
Ethion |
384.5 |