FRCD

C-Jun-amino-terminal kinase-interacting protein 2

Name	C-Jun-amino-terminal kinase-interacting protein 2
Synonyms	IB-2 IB2 Islet-brain-2 JIP-2 JIP2 JNK MAP kinase scaffold protein 2 Mitogen-activated protein kinase 8-interacting protein 2 PRKM8IPL
Gene Name	MAPK8IP2
Organism	Human
Amino acid sequence	>lcl\|BSEQ0008804\|C-Jun-amino-terminal kinase-interacting protein 2 MADRAEMFSLSTFHSLSPPGCRPPQDISLEEFDDEDLSEITDDCGLGLSYDSDHCEKDSL SLGRSEQPHPICSFQDDFQEFEMIDDNEEEDDEDEEEEEEEEEGDGEGQEGGDPGSEAPA PGPLIPSPSVEEPHKHRPTTLRLTTLGAQDSLNNNGGFDLVRPASWQETALCSPAPEALR ELPGPLPATDTGPGGAQSPVRPGCDCEGNRPAEPPAPGGTSPSSDPGIEADLRSRSSGGR GGRRSSQELSSPGSDSEDAGGARLGRMISSISETELELSSDGGSSSSGRSSHLTNSIEEA SSPASEPEPPREPPRRPAFLPVGPDDTNSEYESGSESEPDLSEDADSPWLLSNLVSRMIS EGSSPIRCPGQCLSPAPRPPGEPVSPAGGAAQDSQDPEAAAGPGGVELVDMETLCAPPPP APAAPRPGPAQPGPCLFLSNPTRDTITPLWAAPGRAARPGRACSAACSEEEDEEDDEEEE DAEDSAGSPGGRGTGPSAPRDASLVYDAVKYTLVVDEHTQLELVSLRRCAGLGHDSEEDS GGEASEEEAGAALLGGGQVSGDTSPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCLV NGEEREQTHRAVFRFIPRHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYA HAVPGPAKDLLGSKRSPCWVERFDVQFLGSVEVPCHQGNGILCAAMQKIATARKLTVHLR PPASCDLEISLRGVKLSLSGGGPEFQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLS RFACHVFVSQESMRPVAQSVGRAFLEYYQEHLAYACPTEDIYLE
Number of residues	824
Molecular Weight	87973.915
Theoretical pI	None
GO Classification	Functions protein kinase activator activity beta-amyloid binding protein kinase binding kinesin binding MAP-kinase scaffold activity structural molecule activity Processes excitatory postsynaptic potential nonassociative learning regulation of synaptic transmission, glutamatergic regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity MAPK cascade behavioral fear response dendrite morphogenesis mating behavior positive regulation of stress-activated MAPK cascade social behavior regulation of N-methyl-D-aspartate selective glutamate receptor activity regulation of JNK cascade regulation of receptor activity activation of protein kinase activity JNK cascade signal complex assembly Components neuronal postsynaptic density neuronal cell body intracellular cytoplasm protein complex
General Function	Structural molecule activity
Specific Function	The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	Q13387
UniProtKB Entry Name	JIP2_HUMAN
Cellular Location	Cytoplasm
Gene sequence	>lcl\|BSEQ0013424\|C-Jun-amino-terminal kinase-interacting protein 2 (MAPK8IP2) ATGGCGGATCGCGCGGAGATGTTTTCTCTCTCCACCTTCCACTCGCTGTCGCCGCCGGGC TGCAGGCCTCCCCAGGACATAAGCCTGGAAGAATTTGACGACGAAGATCTGTCTGAGATC ACTGATGACTGTGGCCTGGGCCTCAGCTACGACTCAGACCACTGTGAGAAGGACAGCCTC TCCCTGGGGCGCTCGGAGCAGCCGCACCCCATCTGCTCCTTCCAGGATGACTTCCAGGAG TTTGAGATGATCGATGACAATGAAGAGGAGGACGATGAGGACGAGGAAGAGGAGGAGGAG GAGGAGGAGGGAGATGGGGAAGGCCAGGAGGGAGGAGACCCTGGCTCAGAGGCACCTGCC CCCGGGCCCCTTATCCCCTCCCCTTCCGTGGAGGAGCCCCACAAGCACCGGCCCACCACC CTCCGTCTGACCACACTGGGGGCCCAGGACTCCCTAAACAACAACGGAGGCTTTGACCTG GTGCGTCCGGCCTCCTGGCAGGAGACAGCGCTATGCTCACCCGCCCCGGAGGCCCTCAGA GAGCTCCCGGGCCCCCTCCCTGCCACGGACACCGGGCCCGGCGGGGCGCAGTCGCCAGTG CGCCCGGGTTGCGACTGCGAAGGGAACCGGCCTGCGGAACCCCCTGCGCCAGGGGGGACT TCGCCCTCCTCAGATCCCGGCATCGAGGCTGACCTGAGAAGCCGCTCGAGCGGCGGCCGC GGGGGACGTCGCAGCAGCCAGGAGCTGTCCTCGCCCGGCTCCGACTCGGAGGACGCGGGC GGCGCGCGCCTGGGGCGCATGATCTCGTCCATCTCGGAGACGGAGCTGGAGCTGAGCAGC GATGGCGGAAGCAGCAGCAGCGGCCGCTCCTCGCACCTCACCAACTCCATCGAGGAGGCC TCGTCGCCCGCCTCGGAGCCGGAGCCCCCGCGCGAACCCCCGCGCCGCCCCGCCTTCCTG CCCGTGGGCCCCGACGACACCAACAGCGAGTACGAGTCGGGGTCGGAGTCGGAGCCGGAC CTCAGCGAGGACGCGGACTCGCCCTGGCTGCTCAGCAACCTGGTGAGCCGCATGATCTCC GAGGGCTCCTCGCCCATCCGCTGCCCCGGCCAGTGCCTGTCTCCTGCGCCGCGCCCGCCC GGGGAGCCCGTGTCGCCGGCCGGCGGGGCCGCCCAGGACTCCCAGGACCCCGAGGCGGCC GCGGGGCCCGGCGGCGTGGAGCTGGTGGACATGGAGACGCTGTGCGCGCCGCCGCCGCCC GCGCCCGCCGCGCCTCGACCCGGCCCCGCGCAGCCCGGGCCCTGCCTATTCCTCAGCAAC CCCACGCGTGACACCATCACGCCGCTGTGGGCCGCGCCCGGCCGCGCCGCCCGCCCGGGA CGAGCCTGCTCCGCCGCCTGCTCCGAGGAGGAGGACGAAGAGGACGACGAGGAAGAGGAG GATGCCGAGGACAGTGCGGGGTCCCCCGGGGGCAGGGGCACGGGCCCCTCGGCGCCGCGG GACGCGTCGCTGGTGTACGACGCGGTCAAGTACACGCTGGTGGTGGATGAGCACACGCAG CTGGAGCTGGTGAGCCTGCGGCGCTGTGCTGGGCTGGGCCACGACAGCGAAGAGGACAGC GGCGGGGAGGCCAGCGAGGAGGAGGCGGGCGCGGCGCTGCTAGGCGGCGGTCAGGTCTCG GGGGACACCTCGCCGGACAGCCCTGACCTCACTTTCTCCAAGAAGTTCCTCAATGTCTTC GTCAACAGCACATCTCGGTCCTCCAGCACCGAGTCCTTTGGCCTTTTCTCCTGTCTGGTC AACGGCGAGGAGCGAGAGCAGACTCACCGGGCTGTGTTCAGGTTCATCCCGCGGCATCCA GACGAGCTGGAGCTGGATGTGGATGACCCTGTGTTGGTGGAGGCCGAGGAGGACGACTTC TGGTTCCGTGGCTTCAACATGCGCACGGGGGAGCGCGGTGTGTTTCCTGCCTTCTACGCC CATGCGGTGCCCGGCCCTGCCAAGGACCTGCTGGGGAGTAAGCGGAGCCCCTGCTGGGTG GAGCGCTTTGACGTGCAGTTCCTGGGCTCCGTGGAGGTGCCCTGCCACCAGGGCAACGGC ATCCTGTGTGCAGCCATGCAGAAGATTGCCACTGCCCGGAAACTGACCGTCCACCTGCGC CCTCCTGCCTCCTGTGACCTCGAGATCTCTCTTCGGGGGGTCAAGCTGAGTCTGAGCGGA GGAGGGCCCGAGTTCCAGCGCTGCAGCCATTTCTTCCAGATGAAGAACATCTCCTTCTGC GGCTGCCATCCCCGCAACAGCTGCTATTTCGGCTTCATCACCAAACACCCCCTGCTGAGC CGCTTCGCCTGCCACGTCTTTGTCTCCCAGGAGTCCATGAGGCCGGTGGCGCAGAGTGTG GGCCGCGCCTTCCTGGAGTACTACCAAGAGCACCTGGCGTACGCCTGCCCCACGGAGGAC ATCTACCTGGAGTAG
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID	HGNC:6883
Chromosome Location	22
Locus	None
References	Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ: The JIP group of mitogen-activated protein kinase scaffold proteins. Mol Cell Biol. 1999 Oct;19(10):7245-54.[10490659 ] Negri S, Oberson A, Steinmann M, Sauser C, Nicod P, Waeber G, Schorderet DF, Bonny C: cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein. Genomics. 2000 Mar 15;64(3):324-30.[10756100 ] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.: The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95.[10591208 ] Collins JE, Goward ME, Cole CG, Smink LJ, Huckle EJ, Knowles S, Bye JM, Beare DM, Dunham I: Reevaluating human gene annotation: a second-generation analysis of chromosome 22. Genome Res. 2003 Jan;13(1):27-36.[12529303 ] Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA: Large-scale concatenation cDNA sequencing. Genome Res. 1997 Apr;7(4):353-8.[9110174 ] Schoorlemmer J, Goldfarb M: Fibroblast growth factor homologous factors are intracellular signaling proteins. Curr Biol. 2001 May 15;11(10):793-7.[11378392 ] Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]

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FRCD ID	Name	Exact Mass	Structure
F03272	Cadmium	112.414

FRCD

C-Jun-amino-terminal kinase-interacting protein 2

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