Sodium/potassium-transporting ATPase subunit alpha-4
Name | Sodium/potassium-transporting ATPase subunit alpha-4 |
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Synonyms | 3.6.3.9 ATP1AL2 Na(+)/K(+) ATPase alpha-4 subunit Sodium pump subunit alpha-4 |
Gene Name | ATP1A4 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0008798|Sodium/potassium-transporting ATPase subunit alpha-4 MGLWGKKGTVAPHDQSPRRRPKKGLIKKKMVKREKQKRNMEELKKEVVMDDHKLTLEELS TKYSVDLTKGHSHQRAKEILTRGGPNTVTPPPTTPEWVKFCKQLFGGFSLLLWTGAILCF VAYSIQIYFNEEPTKDNLYLSIVLSVVVIVTGCFSYYQEAKSSKIMESFKNMVPQQALVI RGGEKMQINVQEVVLGDLVEIKGGDRVPADLRLISAQGCKVDNSSLTGESEPQSRSPDFT HENPLETRNICFFSTNCVEGTARGIVIATGDSTVMGRIASLTSGLAVGQTPIAAEIEHFI HLITVVAVFLGVTFFALSLLLGYGWLEAIIFLIGIIVANVPEGLLATVTVCLTLTAKRMA RKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDMTVYEADTTEEQTGKTFT KSSDTWFMLARIAGLCNRADFKANQEILPIAKRATTGDASESALLKFIEQSYSSVAEMRE KNPKVAEIPFNSTNKYQMSIHLREDSSQTHVLMMKGAPERILEFCSTFLLNGQEYSMNDE MKEAFQNAYLELGGLGERVLGFCFLNLPSSFSKGFPFNTDEINFPMDNLCFVGLISMIDP PRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGTETAEEVAARLKIPISK VDASAAKAIVVHGAELKDIQSKQLDQILQNHPEIVFARTSPQQKLIIVEGCQRLGAVVAV TGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKK SIMYTLTSNIPEITPFLMFIILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKR LPRNPKTDNLVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKY LNDLEDSYGQQWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVL IFGILEETLLAAFLSYTPGMDVALRMYPLKITWWLCAIPYSILIFVYDEIRKLLIRQHPD GWVERETYY |
Number of residues | 1029 |
Molecular Weight | 114165.44 |
Theoretical pI | None |
GO Classification |
Functions
ATP binding metal ion binding sodium Processes
cellular sodium ion homeostasis ion transmembrane transport fertilization potassium ion import regulation of cellular pH sperm motility sodium ion transport potassium ion transport establishment or maintenance of transmembrane electrochemical gradient sodium ion export from cell regulation of membrane potential spermatogenesis cellular potassium ion homeostasis transmembrane transport ATP hydrolysis coupled proton transport Components
intracellular membrane-bounded organelle sodium plasma membrane integral component of plasma membrane |
General Function | Sodium:potassium-exchanging atpase activity |
Specific Function | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility. |
Transmembrane Regions | 96-116 140-160 297-316 329-346 779-798 809-829 850-872 925-944 958-976 992-1012 |
GenBank Protein ID | |
UniProtKB ID | Q13733 |
UniProtKB Entry Name | AT1A4_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0019665|Sodium/potassium-transporting ATPase subunit alpha-4 (ATP1A4) ATGATCCAGGCTCTGGCTGGATTCTTTACCTACTTTGTAATCCTGGCTGAGAATGGTTTT AGGCCTGTTGATCTGCTGGGCATCCGCCTCCACTGGGAAGATAAATACTTGAATGACCTG GAGGACAGCTACGGACAGCAGTGGACCTATGAGCAACGAAAAGTTGTGGAGTTCACATGC CAAACGGCCTTTTTTGTCACCATCGTGGTTGTGCAGTGGGCGGATCTCATCATCTCCAAG ACTCGCCGCAACTCACTTTTCCAGCAGGGCATGAGAAACAAAGTCTTAATATTTGGGATC CTGGAGGAGACACTCTTGGCTGCATTTCTGTCCTACACTCCAGGCATGGACGTGGCCCTG CGAATGTACCCACTCAAGATAACCTGGTGGCTCTGTGCCATTCCCTACAGTATTCTCATC TTCGTCTATGATGAAATCAGAAAACTCCTCATCCGTCAGCACCCGGATGGCTGGGTGGAA AGGGAGACGTACTACTAA |
GenBank Gene ID | |
GeneCard ID | None |
GenAtlas ID | |
HGNC ID | HGNC:14073 |
Chromosome Location | 1 |
Locus | None |
References |
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