Kinesin-like protein KIF22


NameKinesin-like protein KIF22
SynonymsKID Kinesin-like DNA-binding protein Kinesin-like protein 4 KNSL4
Gene NameKIF22
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009153|Kinesin-like protein KIF22
MAAGGSTQQRRREMAAASAAAISGAGRCRLSKIGATRRPPPARVRVAVRLRPFVDGTAGA
SDPPCVRGMDSCSLEIANWRNHQETLKYQFDAFYGERSTQQDIYAGSVQPILRHLLEGQN
ASVLAYGPTGAGKTHTMLGSPEQPGVIPRALMDLLQLTREEGAEGRPWALSVTMSYLEIY
QEKVLDLLDPASGDLVIREDCRGNILIPGLSQKPISSFADFERHFLPASRNRTVGATRLN
QRSSRSHAVLLVKVDQRERLAPFRQREGKLYLIDLAGSEDNRRTGNKGLRLKESGAINTS
LFVLGKVVDALNQGLPRVPYRDSKLTRLLQDSLGGSAHSILIANIAPERRFYLDTVSALN
FAARSKEVINRPFTNESLQPHALGPVKLSQKELLGPPEAKRARGPEEEEIGSPEPMAAPA
SASQKLSPLQKLSSMDPAMLERLLSLDRLLASQGSQGAPLLSTPKRERMVLMKTVEEKDL
EIERLKTKQKELEAKMLAQKAEEKENHCPTMLRPLSHRTVTGAKPLKKAVVMPLQLIQEQ
AASPNAEIHILKNKGRKRKLESLDALEPEEKAEDCWELQISPELLAHGRQKILDLLNEGS
ARDLRSLQRIGPKKAQLIVGWRELHGPFSQVEDLERVEGITGKQMESFLKANILGLAAGQ
RCGAS
Number of residues665
Molecular Weight73261.38
Theoretical pINone
GO Classification
Functions
    ATPase activity
    microtubule motor activity
    ATP binding
    DNA binding
Processes
    metaphase plate congression
    sister chromatid cohesion
    mitotic nuclear division
    microtubule-based movement
    antigen processing and presentation of exogenous peptide antigen via MHC class II
    blood coagulation
    DNA repair
    mitotic metaphase plate congression
Components
    chromatin
    cytoplasm
    cytosol
    microtubule
    focal adhesion
    mitotic spindle
    kinesin complex
    nucleus
    kinetochore
General FunctionMicrotubule motor activity
Specific FunctionKinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ14807
UniProtKB Entry NameKIF22_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013643|Kinesin-like protein KIF22 (KIF22)
ATGGACAGCTGCTCTCTAGAGATTGCTAACTGGAGGAACCACCAGGAGACTCTCAAATAC
CAGTTTGATGCCTTCTATGGGGAGAGGAGTACTCAGCAGGACATCTATGCAGGTTCAGTG
CAGCCCATCCTAAGGCACTTGCTGGAAGGGCAGAATGCCAGTGTGCTTGCCTATGGACCC
ACAGGAGCTGGGAAGACGCACACAATGCTGGGCAGCCCAGAGCAACCTGGGGTGATCCCG
CGGGCTCTCATGGACCTCCTGCAGCTCACAAGGGAGGAGGGTGCCGAGGGCCGGCCATGG
GCCCTTTCTGTCACCATGTCTTACCTAGAGATCTACCAGGAGAAGGTATTAGACCTCCTG
GACCCTGCTTCGGGAGACCTGGTAATCCGAGAAGACTGCCGGGGGAATATCCTGATTCCG
GGTCTCTCCCAGAAGCCCATCAGTAGCTTTGCTGATTTTGAGCGGCACTTCCTGCCAGCC
AGTCGAAATCGGACTGTAGGAGCCACCCGGCTCAACCAGCGCTCCTCCCGCAGTCATGCT
GTGCTCCTGGTCAAGGTGGACCAGCGGGAACGTTTGGCCCCATTTCGCCAGCGAGAGGGA
AAACTCTACCTGATTGACTTGGCTGGGTCAGAGGACAACCGGCGCACAGGCAACAAGGGC
CTTCGGCTAAAAGAGAGTGGAGCCATCAACACCTCCCTGTTTGTCCTGGGCAAAGTGGTA
GATGCGCTGAATCAGGGCCTCCCTCGTGTACCTTATCGGGACAGCAAGCTCACTCGCCTA
TTGCAGGACTCTCTGGGTGGCTCAGCCCACAGTATCCTTATTGCCAACATTGCCCCTGAG
AGACGCTTCTACCTAGACACAGTCTCCGCACTCAACTTTGCTGCCAGGTCCAAGGAGGTG
ATCAATCGGCCTTTTACCAATGAGAGCCTGCAGCCTCATGCCTTGGGACCTGTTAAGCTG
TCTCAGAAAGAATTGCTTGGTCCACCAGAGGCAAAGAGAGCCCGAGGCCCTGAGGAAGAG
GAGATCGGGAGCCCTGAGCCCATGGCAGCTCCAGCCTCTGCCTCCCAGAAACTCAGCCCC
CTACAGAAGCTAAGCAGCATGGACCCGGCCATGCTGGAGCGCCTCCTCAGCTTGGACCGT
CTGCTTGCCTCCCAGGGGAGCCAGGGGGCCCCTCTGTTGAGTACCCCAAAGCGAGAGCGG
ATGGTGCTAATGAAGACAGTGGAAGAGAAGGACCTAGAGATTGAGAGGCTTAAGACGAAG
CAAAAAGAACTGGAGGCCAAGATGTTGGCCCAGAAGGCTGAGGAAAAGGAGAACCATTGT
CCCACAATGCTCCGGCCCCTTTCACATCGCACAGTCACAGGGGCAAAGCCCCTGAAAAAG
GCTGTGGTGATGCCCCTACAGCTAATTCAGGAGCAGGCAGCATCCCCAAATGCCGAGATC
CACATCCTGAAGAATAAAGGCCGGAAGAGAAAGCTGGAGTCCCTGGATGCCCTAGAGCCT
GAGGAGAAGGCTGAGGACTGCTGGGAGCTACAGATCAGCCCGGAGCTACTGGCTCATGGG
CGCCAAAAAATACTGGATCTGCTGAACGAAGGCTCAGCCCGAGATCTCCGCAGTCTTCAG
CGCATTGGCCCGAAGAAGGCCCAGCTAATCGTGGGCTGGCGGGAGCTCCACGGCCCCTTC
AGCCAGGTGGAGGACCTGGAACGCGTGGAGGGCATAACGGGGAAACAGATGGAGTCCTTC
CTGAAGGCAAACATCCTGGGTCTCGCCGCCGGCCAGCGCTGTGGCGCCTCCTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:6391
Chromosome Location16
LocusNone
References
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  5. Germani A, Bruzzoni-Giovanelli H, Fellous A, Gisselbrecht S, Varin-Blank N, Calvo F: SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. Oncogene. 2000 Dec 7;19(52):5997-6006.[11146551 ]
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  7. Santamaria A, Nagel S, Sillje HH, Nigg EA: The spindle protein CHICA mediates localization of the chromokinesin Kid to the mitotic spindle. Curr Biol. 2008 May 20;18(10):723-9. doi: 10.1016/j.cub.2008.04.041.[18485706 ]
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  9. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007.[19690332 ]
  10. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475.[20068231 ]
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