Sonic hedgehog protein
Name | Sonic hedgehog protein |
---|---|
Synonyms | HHG-1 SHH |
Gene Name | SHH |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0013929|Sonic hedgehog protein MLLLARCLLLVLVSSLLVCSGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASG RYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGV KLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAH IHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLT FLDRDDGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGPPSGGALG PRALFASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILINRVL ASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGGRVALTAPGA ADAPGAGATAGIHWYSQLLYQIGTWLLDSEALHPLGMAVKSS |
Number of residues | 462 |
Molecular Weight | 49606.685 |
Theoretical pI | None |
GO Classification |
Functions
patched binding laminin-1 binding glycosaminoglycan binding zinc ion binding calcium ion binding morphogen activity peptidase activity Processes
intein-mediated protein splicing negative regulation of transcription from RNA polymerase II promoter right lung development negative regulation of proteasomal ubiquitin-dependent protein catabolic process epithelial cell proliferation involved in salivary gland morphogenesis palate development negative regulation of ureter smooth muscle cell differentiation patterning of blood vessels positive regulation of transcription, DNA-templated positive regulation of T cell differentiation in thymus camera-type eye development canonical Wnt signaling pathway dorsal/ventral pattern formation left lung development negative regulation of cell differentiation smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation salivary gland cavitation hair follicle morphogenesis Bergmann glial cell differentiation neuroblast proliferation apoptotic signaling pathway protein localization to nucleus positive regulation of ureter smooth muscle cell differentiation central nervous system development cell fate specification lung epithelium development thalamus development somite development positive regulation of immature T cell proliferation in thymus limb bud formation intermediate filament organization neuron fate commitment negative thymic T cell selection lung development primary prostatic bud elongation spinal cord motor neuron differentiation ectoderm development lymphoid progenitor cell differentiation myotube differentiation striated muscle tissue development embryo development lung lobe morphogenesis hindbrain development organ formation forebrain development heart development regulation of mesenchymal cell proliferation involved in prostate gland development pancreas development embryonic digit morphogenesis bud outgrowth involved in lung branching mesenchymal smoothened signaling pathway involved in prostate gland development negative regulation of T cell proliferation telencephalon regionalization artery development positive regulation of smoothened signaling pathway lung-associated mesenchyme development cell development cell-cell signaling pattern specification process embryonic hindlimb morphogenesis negative regulation of apoptotic process regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry androgen metabolic process embryonic foregut morphogenesis CD4-positive or CD8-positive, alpha-beta T cell lineage commitment positive regulation of protein import into nucleus metanephric mesenchymal cell proliferation involved in metanephros development positive regulation of oligodendrocyte differentiation thyroid gland development negative regulation of canonical Wnt signaling pathway mesenchymal cell proliferation involved in lung development embryonic limb morphogenesis polarity specification of anterior/posterior axis positive regulation of cell division positive regulation of transcription from RNA polymerase II promoter regulation of odontogenesis prostate gland development embryonic forelimb morphogenesis establishment of cell polarity multicellular structure septum development odontogenesis of dentin-containing tooth trachea morphogenesis myoblast differentiation midbrain development cerebellar granule cell precursor proliferation positive regulation of hh target transcription factor activity dorsal/ventral neural tube patterning smoothened signaling pathway regulation of prostatic bud formation osteoblast development positive regulation of epithelial cell proliferation involved in prostate gland development oligodendrocyte development blood coagulation negative regulation of alpha-beta T cell differentiation inner ear development ventral midline development positive regulation of skeletal muscle tissue development positive regulation of kidney smooth muscle cell differentiation negative regulation of cholesterol efflux positive regulation of Wnt signaling pathway stem cell development axon guidance epithelial-mesenchymal signaling involved in prostate gland development positive regulation of cell proliferation regulation of protein localization to nucleus positive regulation of neuroblast proliferation heart looping negative regulation of kidney smooth muscle cell differentiation negative regulation of cell migration branching involved in salivary gland morphogenesis positive regulation of mesenchymal cell proliferation involved in ureter development endocytosis prostate epithelial cord elongation regulation of cell proliferation formation of anatomical boundary regulation of proteolysis T cell differentiation in thymus embryonic digestive tract morphogenesis metanephros development negative regulation of mesenchymal cell apoptotic process positive regulation of alpha-beta T cell differentiation positive regulation of sclerotome development male genitalia development vasculogenesis determination of left/right asymmetry in lateral mesoderm hindgut morphogenesis cellular response to lithium ion renal system development thymus development embryonic pattern specification positive thymic T cell selection negative regulation of transcription elongation from RNA polymerase II promoter neural crest cell migration embryonic skeletal system development positive regulation of skeletal muscle cell proliferation branching morphogenesis of an epithelial tube branching involved in ureteric bud morphogenesis positive regulation of striated muscle cell differentiation Components
nucleus plasma membrane extracellular space cell surface proteinaceous extracellular matrix cytosol membrane raft endoplasmic reticulum lumen extracellular region |
General Function | Zinc ion binding |
Specific Function | Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity). |
Transmembrane Regions | |
GenBank Protein ID | |
UniProtKB ID | Q15465 |
UniProtKB Entry Name | SHH_HUMAN |
Cellular Location | Secreted |
Gene sequence | >lcl|BSEQ0013930|Sonic hedgehog protein (SHH) ATGCTGCTGCTGGCGAGATGTCTGCTGCTAGTCCTCGTCTCCTCGCTGCTGGTATGCTCG GGACTGGCGTGCGGACCGGGCAGGGGGTTCGGGAAGAGGAGGCACCCCAAAAAGCTGACC CCTTTAGCCTACAAGCAGTTTATCCCCAATGTGGCCGAGAAGACCCTAGGCGCCAGCGGA AGGTATGAAGGGAAGATCTCCAGAAACTCCGAGCGATTTAAGGAACTCACCCCCAATTAC AACCCCGACATCATATTTAAGGATGAAGAAAACACCGGAGCGGACAGGCTGATGACTCAG AGGTGTAAGGACAAGTTGAACGCTTTGGCCATCTCGGTGATGAACCAGTGGCCAGGAGTG AAACTGCGGGTGACCGAGGGCTGGGACGAAGATGGCCACCACTCAGAGGAGTCTCTGCAC TACGAGGGCCGCGCAGTGGACATCACCACGTCTGACCGCGACCGCAGCAAGTACGGCATG CTGGCCCGCCTGGCGGTGGAGGCCGGCTTCGACTGGGTGTACTACGAGTCCAAGGCACAT ATCCACTGCTCGGTGAAAGCAGAGAACTCGGTGGCGGCCAAATCGGGAGGCTGCTTCCCG GGCTCGGCCACGGTGCACCTGGAGCAGGGCGGCACCAAGCTGGTGAAGGACCTGAGCCCC GGGGACCGCGTGCTGGCGGCGGACGACCAGGGCCGGCTGCTCTACAGCGACTTCCTCACT TTCCTGGACCGCGACGACGGCGCCAAGAAGGTCTTCTACGTGATCGAGACGCGGGAGCCG CGCGAGCGCCTGCTGCTCACCGCCGCGCACCTGCTCTTTGTGGCGCCGCACAACGACTCG GCCACCGGGGAGCCCGAGGCGTCCTCGGGCTCGGGGCCGCCTTCCGGGGGCGCACTGGGG CCTCGGGCGCTGTTCGCCAGCCGCGTGCGCCCGGGCCAGCGCGTGTACGTGGTGGCCGAG CGTGACGGGGACCGCCGGCTCCTGCCCGCCGCTGTGCACAGCGTGACCCTAAGCGAGGAG GCCGCGGGCGCCTACGCGCCGCTCACGGCCCAGGGCACCATTCTCATCAACCGGGTGCTG GCCTCGTGCTACGCGGTCATCGAGGAGCACAGCTGGGCGCACCGGGCCTTCGCGCCCTTC CGCCTGGCGCACGCGCTCCTGGCTGCACTGGCGCCCGCGCGCACGGACCGCGGCGGGGAC AGCGGCGGCGGGGACCGCGGGGGCGGCGGCGGCAGAGTAGCCCTAACCGCTCCAGGTGCT GCCGACGCTCCGGGTGCGGGGGCCACCGCGGGCATCCACTGGTACTCGCAGCTGCTCTAC CAAATAGGCACCTGGCTCCTGGACAGCGAGGCCCTGCACCCGCTGGGCATGGCGGTCAAG TCCAGCTGA |
GenBank Gene ID | |
GeneCard ID | None |
GenAtlas ID | |
HGNC ID | HGNC:10848 |
Chromosome Location | 7 |
Locus | None |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Jervine |
425.613 |
||
Cyclopamine |
411.63 |