Mothers against decapentaplegic homolog 1

NameMothers against decapentaplegic homolog 1
SynonymsBSP-1 BSP1 hSMAD1 JV4-1 MAD homolog 1 Mad-related protein 1 MADH1 MADR1 SMAD 1 SMAD family member 1 Smad1 Transforming growth factor-beta-signaling protein 1
Gene NameSMAD1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009303|Mothers against decapentaplegic homolog 1
MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQ
PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEV
CINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPN
SHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQ
PMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW
GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
Number of residues465
Molecular Weight52259.72
Theoretical pINone
GO Classification
Functions
    protein kinase binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
metal ion binding
co-SMAD binding
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
identical protein binding
I-SMAD binding
transcription factor activity, sequence-specific DNA binding
receptor signaling protein activity
RNA polymerase II core promoter sequence-specific DNA binding
Processes
    positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
SMAD protein signal transduction
inflammatory response
bone development
SMAD protein complex assembly
transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
embryonic pattern specification
primary miRNA processing
positive regulation of gene expression
midbrain development
hindbrain development
BMP signaling pathway
ureteric bud development
cardiac muscle cell proliferation
cellular response to BMP stimulus
gamete generation
positive regulation of osteoblast differentiation
mesodermal cell fate commitment
MAPK cascade
signal transduction
homeostatic process
osteoblast fate commitment
negative regulation of cell proliferation
cartilage development
positive regulation of transcription from RNA polymerase II promoter
positive regulation of cartilage development
Components
    nucleus
SMAD protein complex
nuclear inner membrane
integral component of membrane
cytosol
intracellular
nucleoplasm
cytoplasm
transcription factor complex
protein complex
General FunctionTransforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Specific FunctionTranscriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ15797
UniProtKB Entry NameSMAD1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013729|Mothers against decapentaplegic homolog 1 (SMAD1)
ATGAATGTGACAAGTTTATTTTCCTTTACAAGTCCAGCTGTGAAGAGACTTCTTGGGTGG
AAACAGGGCGATGAAGAAGAAAAATGGGCAGAGAAAGCTGTTGATGCTTTGGTGAAAAAA
CTGAAGAAAAAGAAAGGTGCCATGGAGGAACTGGAAAAGGCCTTGAGCTGCCCAGGGCAA
CCGAGTAACTGTGTCACCATTCCCCGCTCTCTGGATGGCAGGCTGCAAGTCTCCCACCGG
AAGGGACTGCCTCATGTCATTTACTGCCGTGTGTGGCGCTGGCCCGATCTTCAGAGCCAC
CATGAACTAAAACCACTGGAATGCTGTGAGTTTCCTTTTGGTTCCAAGCAGAAGGAGGTC
TGCATCAATCCCTACCACTATAAGAGAGTAGAAAGCCCTGTACTTCCTCCTGTGCTGGTT
CCAAGACACAGCGAATATAATCCTCAGCACAGCCTCTTAGCTCAGTTCCGTAACTTAGGA
CAAAATGAGCCTCACATGCCACTCAACGCCACTTTTCCAGATTCTTTCCAGCAACCCAAC
AGCCACCCGTTTCCTCACTCTCCCAATAGCAGTTACCCAAACTCTCCTGGGAGCAGCAGC
AGCACCTACCCTCACTCTCCCACCAGCTCAGACCCAGGAAGCCCTTTCCAGATGCCAGCT
GATACGCCCCCACCTGCTTACCTGCCTCCTGAAGACCCCATGACCCAGGATGGCTCTCAG
CCGATGGACACAAACATGATGGCGCCTCCCCTGCCCTCAGAAATCAACAGAGGAGATGTT
CAGGCGGTTGCTTATGAGGAACCAAAACACTGGTGCTCTATTGTCTACTATGAGCTCAAC
AATCGTGTGGGTGAAGCGTTCCATGCCTCCTCCACAAGTGTGTTGGTGGATGGTTTCACT
GATCCTTCCAACAATAAGAACCGTTTCTGCCTTGGGCTGCTCTCCAATGTTAACCGGAAT
TCCACTATTGAAAACACCAGGCGGCATATTGGAAAAGGAGTTCATCTTTATTATGTTGGA
GGGGAGGTGTATGCCGAATGCCTTAGTGACAGTAGCATCTTTGTGCAAAGTCGGAACTGC
AACTACCATCATGGATTTCATCCTACTACTGTTTGCAAGATCCCTAGTGGGTGTAGTCTG
AAAATTTTTAACAACCAAGAATTTGCTCAGTTATTGGCACAGTCTGTGAACCATGGATTT
GAGACAGTCTATGAGCTTACAAAAATGTGTACTATACGTATGAGCTTTGTGAAGGGCTGG
GGAGCAGAATACCACCGCCAGGATGTTACTAGCACCCCCTGCTGGATTGAGATACATCTG
CACGGCCCCCTCCAGTGGCTGGATAAAGTTCTTACTCAAATGGGTTCACCTCATAATCCT
ATTTCATCTGTATCTTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:6767
Chromosome Location4
LocusNone
References
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