Nuclear factor erythroid 2-related factor 2

NameNuclear factor erythroid 2-related factor 2
SynonymsHEBP1 NF-E2-related factor 2 NRF2 Nuclear factor, erythroid derived 2, like 2
Gene NameNFE2L2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009238|Nuclear factor erythroid 2-related factor 2
MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQE
QLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCM
QLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGM
QQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVG
NCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMP
SPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHS
VESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDA
QCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVD
FNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLL
KEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKP
DVKKN
Number of residues605
Molecular Weight67825.9
Theoretical pINone
GO Classification
Functions
    transcription factor activity, sequence-specific DNA binding
transcription regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
protein domain specific binding
RNA polymerase II activating transcription factor binding
transcription regulatory region DNA binding
DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
Processes
    positive regulation of transcription from RNA polymerase II promoter
positive regulation of blood coagulation
proteasome-mediated ubiquitin-dependent protein catabolic process
inflammatory response
positive regulation of reactive oxygen species metabolic process
protein ubiquitination
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
cellular response to glucose starvation
cellular response to fluid shear stress
cellular response to laminar fluid shear stress
endoplasmic reticulum unfolded protein response
positive regulation of glucose import
regulation of embryonic development
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
PERK-mediated unfolded protein response
cell redox homeostasis
positive regulation of transcription from RNA polymerase II promoter in response to stress
negative regulation of hydrogen peroxide-induced cell death
transcription from RNA polymerase II promoter
negative regulation of hematopoietic stem cell differentiation
cellular response to drug
positive regulation of glutathione biosynthetic process
negative regulation of endothelial cell apoptotic process
regulation of removal of superoxide radicals
cellular response to oxidative stress
positive regulation of gene expression
cellular response to tumor necrosis factor
cellular response to hydrogen peroxide
proteasomal ubiquitin-independent protein catabolic process
Components
    chromatin
centrosome
protein-DNA complex
cytoplasm
cytosol
nucleus
plasma membrane
General FunctionTranscriptional activator activity, rna polymerase ii distal enhancer sequence-specific binding
Specific FunctionTranscription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ16236
UniProtKB Entry NameNF2L2_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0019750|Nuclear factor erythroid 2-related factor 2 (NFE2L2)
ATGGATTTGATTGACATACTTTGGAGGCAAGATATAGATCTTGGAGTAAGTCGAGAAGTA
TTTGACTTCAGTCAGCGACGGAAAGAGTATGAGCTGGAAAAACAGAAAAAACTTGAAAAG
GAAAGACAAGAACAACTCCAAAAGGAGCAAGAGAAAGCCTTTTTCGCTCAGTTACAACTA
GATGAAGAGACAGGTGAATTTCTCCCAATTCAGCCAGCCCAGCACATCCAGTCAGAAACC
AGTGGATCTGCCAACTACTCCCAGGTTGCCCACATTCCCAAATCAGATGCTTTGTACTTT
GATGACTGCATGCAGCTTTTGGCGCAGACATTCCCGTTTGTAGATGACAATGAGGTTTCT
TCGGCTACGTTTCAGTCACTTGTTCCTGATATTCCCGGTCACATCGAGAGCCCAGTCTTC
ATTGCTACTAATCAGGCTCAGTCACCTGAAACTTCTGTTGCTCAGGTAGCCCCTGTTGAT
TTAGACGGTATGCAACAGGACATTGAGCAAGTTTGGGAGGAGCTATTATCCATTCCTGAG
TTACAGTGTCTTAATATTGAAAATGACAAGCTGGTTGAGACTACCATGGTTCCAAGTCCA
GAAGCCAAACTGACAGAAGTTGACAATTATCATTTTTACTCATCTATACCCTCAATGGAA
AAAGAAGTAGGTAACTGTAGTCCACATTTTCTTAATGCTTTTGAGGATTCCTTCAGCAGC
ATCCTCTCCACAGAAGACCCCAACCAGTTGACAGTGAACTCATTAAATTCAGATGCCACA
GTCAACACAGATTTTGGTGATGAATTTTATTCTGCTTTCATAGCTGAGCCCAGTATCAGC
AACAGCATGCCCTCACCTGCTACTTTAAGCCATTCACTCTCTGAACTTCTAAATGGGCCC
ATTGATGTTTCTGATCTATCACTTTGCAAAGCTTTCAACCAAAACCACCCTGAAAGCACA
GCAGAATTCAATGATTCTGACTCCGGCATTTCACTAAACACAAGTCCCAGTGTGGCATCA
CCAGAACACTCAGTGGAATCTTCCAGCTATGGAGACACACTACTTGGCCTCAGTGATTCT
GAAGTGGAAGAGCTAGATAGTGCCCCTGGAAGTGTCAAACAGAATGGTCCTAAAACACCA
GTACATTCTTCTGGGGATATGGTACAACCCTTGTCACCATCTCAGGGGCAGAGCACTCAC
GTGCATGATGCCCAATGTGAGAACACACCAGAGAAAGAATTGCCTGTAAGTCCTGGTCAT
CGGAAAACCCCATTCACAAAAGACAAACATTCAAGCCGCTTGGAGGCTCATCTCACAAGA
GATGAACTTAGGGCAAAAGCTCTCCATATCCCATTCCCTGTAGAAAAAATCATTAACCTC
CCTGTTGTTGACTTCAACGAAATGATGTCCAAAGAGCAGTTCAATGAAGCTCAACTTGCA
TTAATTCGGGATATACGTAGGAGGGGTAAGAATAAAGTGGCTGCTCAGAATTGCAGAAAA
AGAAAACTGGAAAATATAGTAGAACTAGAGCAAGATTTAGATCATTTGAAAGATGAAAAA
GAAAAATTGCTCAAAGAAAAAGGAGAAAATGACAAAAGCCTTCACCTACTGAAAAAACAA
CTCAGCACCTTATATCTCGAAGTTTTCAGCATGCTACGTGATGAAGATGGAAAACCTTAT
TCTCCTAGTGAATACTCCCTGCAGCAAACAAGAGATGGCAATGTTTTCCTTGTTCCCAAA
AGTAAGAAGCCAGATGTTAAGAAAAACTAG
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:7782
Chromosome Location2
LocusNone
References
  1. Kaitsuka T, Tomizawa K, Matsushita M: Transformation of eEF1Bdelta into heat-shock response transcription factor by alternative splicing. EMBO Rep. 2011 Jul 1;12(7):673-81. doi: 10.1038/embor.2011.82.[21597468 ]
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