Calcium-activated potassium channel subunit beta-1
Name | Calcium-activated potassium channel subunit beta-1 |
---|---|
Synonyms | BK channel subunit beta-1 BKbeta BKbeta1 Calcium-activated potassium channel subunit beta Calcium-activated potassium channel, subfamily M subunit beta-1 Charybdotoxin receptor subunit beta-1 Hbeta1 K(VCA)beta-1 Maxi K channel subunit beta-1 Slo-beta Slo-beta-1 |
Gene Name | KCNMB1 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0037281|Calcium-activated potassium channel subunit beta-1 MVKKLVMAQKRGETRALCLGVTMVVCAVITYYILVTTVLPLYQKSVWTQESKCHLIETNI RDQEELKGKKVPQYPCLWVNVSAAGRWAVLYHTEDTRDQNQQCSYIPGSVDNYQTARADV EKVRAKFQEQQVFYCFSAPRGNETSVLFQRLYGPQALLFSLFWPTFLLTGGLLIIAMVKS NQYLSILAAQK |
Number of residues | 191 |
Molecular Weight | 21797.27 |
Theoretical pI | 8.76 |
GO Classification |
Functions
calcium-activated potassium channel activity potassium channel regulator activity Processes
detection of calcium ion blood coagulation potassium ion transport synaptic transmission potassium ion transmembrane transport Components
plasma membrane voltage-gated potassium channel complex |
General Function | Potassium channel regulator activity |
Specific Function | Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate. |
Transmembrane Regions | 19-39 158-178 |
GenBank Protein ID | 1326067 |
UniProtKB ID | Q16558 |
UniProtKB Entry Name | KCMB1_HUMAN |
Cellular Location | Membrane |
Gene sequence | >lcl|BSEQ0013099|Calcium-activated potassium channel subunit beta-1 (KCNMB1) ATGGTGAAGAAGCTGGTGATGGCCCAGAAGCGGGGAGAGACACGAGCCCTTTGCCTGGGT GTAACCATGGTGGTGTGTGCCGTCATCACCTACTACATCCTGGTCACGACTGTGCTGCCC CTCTACCAGAAAAGCGTGTGGACCCAGGAATCCAAGTGCCACCTGATTGAGACCAACATC AGGGACCAGGAGGAGCTGAAGGGCAAGAAGGTGCCCCAGTACCCATGCCTGTGGGTCAAC GTGTCAGCTGCCGGCAGGTGGGCTGTGCTGTACCACACGGAGGACACTCGGGACCAGAAC CAGCAGTGCTCCTACATCCCAGGCAGCGTGGACAATTACCAGACGGCCCGGGCCGACGTG GAGAAGGTCAGAGCCAAATTCCAAGAGCAGCAGGTCTTCTACTGCTTCTCCGCACCTCGG GGGAACGAAACCAGCGTCCTATTCCAGCGCCTCTACGGGCCCCAGGCCCTCCTCTTCTCC CTCTTCTGGCCCACCTTCCTGCTGACCGGTGGCCTCCTCATTATCGCCATGGTGAAGAGC AACCAGTACCTGTCCATCCTGGCGGCCCAGAAGTAG |
GenBank Gene ID | U25138 |
GeneCard ID | None |
GenAtlas ID | |
HGNC ID | HGNC:6285 |
Chromosome Location | 5 |
Locus | 5q34 |
References |
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