Histone H3.1t


NameHistone H3.1t
SynonymsH3/g H3/t H3FT
Gene NameHIST3H3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0020821|Histone H3.1t
MARTKQTARKSTGGKAPRKQLATKVARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTE
LLIRKLPFQRLMREIAQDFKTDLRFQSSAVMALQEACESYLVGLFEDTNLCVIHAKRVTI
MPKDIQLARRIRGERA
Number of residues136
Molecular Weight15508.105
Theoretical pINone
GO Classification
Functions
    DNA binding
    histone binding
Processes
    double-strand break repair via nonhomologous end joining
    telomere maintenance
    protein heterotetramerization
    negative regulation of protein oligomerization
    DNA repair
    nucleosome assembly
    double-strand break repair
    double-strand break repair via homologous recombination
Components
    nucleus
    nuclear chromosome, telomeric region
    nuclear nucleosome
    extracellular exosome
    nucleosome
    nucleoplasm
General FunctionHistone binding
Specific FunctionCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ16695
UniProtKB Entry NameH31T_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0020822|Histone H3.1t (HIST3H3)
ATGGCCCGAACCAAGCAGACTGCGCGCAAGTCAACGGGTGGCAAGGCGCCGCGCAAGCAG
CTGGCCACCAAGGTGGCTCGCAAGAGCGCACCTGCCACTGGCGGCGTGAAGAAGCCGCAC
CGCTACCGGCCCGGCACGGTGGCGCTTCGCGAGATCCGCCGCTACCAGAAGTCCACTGAG
CTGCTAATCCGCAAGTTGCCCTTCCAGCGGCTGATGCGCGAGATCGCTCAGGACTTTAAG
ACCGACCTGCGCTTCCAGAGCTCGGCCGTGATGGCGCTGCAGGAGGCGTGCGAGTCTTAC
CTGGTGGGGCTGTTTGAGGACACCAACCTGTGTGTCATCCATGCCAAACGGGTCACCATC
ATGCCTAAGGACATCCAGCTGGCACGCCGTATCCGCGGGGAGCGGGCCTAG
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:4778
Chromosome Location1
LocusNone
References
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