Receptor-type tyrosine-protein phosphatase O
Name | Receptor-type tyrosine-protein phosphatase O |
---|---|
Synonyms | 3.1.3.48 GLEPP1 Glomerular epithelial protein 1 Protein tyrosine phosphatase U2 PTP-U2 PTPase U2 PTPU2 R-PTP-O |
Gene Name | PTPRO |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0009013|Receptor-type tyrosine-protein phosphatase O MGHLPTGIHGARRLLPLLWLFVLFKNATAFHVTVQDDNNIVVSLEASDVISPASVYVVKI TGESKNYFFEFEEFNSTLPPPVIFKASYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLP VTSVSIYDYKPSPETGVLFEIHYPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGKTVFNH WLPGMCYSNITFQLVSEATFNKSTLVEYSGVSHEPKQHRTAPYPPQNISVRIVNLNKNNW EEQSGNFPEESFMRSQDTIGKEKLFHFTEETPEIPSGNISSGWPDFNSSDYETTSQPYWW DSASAAPESEDEFVSVLPMEYENNSTLSETEKSTSGSFSFFPVQMILTWLPPKPPTAFDG FHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSSSGSCETRKSQSAKSLSF YISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQR LEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYP LGPTAVVLSWTRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLP AWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTTDL SHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVK LEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTI SSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVT LIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWRRSIFAFLTLLPSCLWTDYLLAFY INPWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLP LNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRND FWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRH FRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGV GRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK QQFCISDVIYENVSKS |
Number of residues | 1216 |
Molecular Weight | 138342.845 |
Theoretical pI | None |
GO Classification |
Functions
phosphatase activity protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity protein homodimerization activity Wnt-protein binding Processes
slit diaphragm assembly negative regulation of glomerular filtration peptidyl-tyrosine dephosphorylation protein dephosphorylation glomerulus development regulation of glomerular filtration negative regulation of neuron projection development monocyte chemotaxis axon guidance glomerular visceral epithelial cell differentiation negative regulation of canonical Wnt signaling pathway lamellipodium assembly negative regulation of cell-substrate adhesion cell morphogenesis negative regulation of retinal ganglion cell axon guidance Components
neuron projection lamellipodium apical plasma membrane growth cone plasma membrane lateral plasma membrane integral component of membrane dendritic spine extracellular exosome axon integral component of plasma membrane |
General Function | Wnt-protein binding |
Specific Function | Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity). |
Transmembrane Regions | 823-843 |
GenBank Protein ID | |
UniProtKB ID | Q16827 |
UniProtKB Entry Name | PTPRO_HUMAN |
Cellular Location | Membrane |
Gene sequence | >lcl|BSEQ0013563|Receptor-type tyrosine-protein phosphatase O (PTPRO) ATGGGGCACCTGCCCACGGGGATACACGGCGCCCGCCGCCTCCTGCCTCTGCTCTGGCTC TTTGTGCTGTTCAAGAATGCTACAGCTTTCCATGTAACTGTCCAAGATGATAATAACATC GTTGTCTCATTAGAAGCTTCAGACGTCATCAGTCCAGCATCTGTGTATGTTGTGAAGATA ACTGGTGAATCCAAAAATTATTTCTTCGAATTTGAGGAATTCAACAGCACTTTGCCTCCT CCTGTTATTTTCAAGGCCAGTTATCATGGCCTTTATTATATAATCACTCTGGTAGTGGTA AATGGAAATGTGGTGACCAAGCCATCCAGATCAATCACTGTGTTAACAAAACCTCTACCT GTAACCAGTGTTTCCATATATGACTATAAACCTTCTCCTGAAACAGGAGTCCTGTTTGAA ATACATTATCCAGAAAAATATAACGTTTTCACAAGAGTGAACATTAGCTACTGGGAAGGT AAAGACTTCCGGACAATGCTATATAAAGATTTCTTTAAGGGAAAAACAGTATTTAATCAC TGGCTGCCAGGAATGTGTTATAGTAATATCACCTTTCAGCTGGTATCTGAGGCAACTTTT AATAAAAGTACCCTTGTTGAGTACAGTGGTGTCAGTCACGAACCCAAACAGCACAGAACT GCCCCTTATCCACCTCAAAATATTTCCGTTCGTATCGTAAACTTGAACAAAAACAACTGG GAAGAACAGAGTGGCAATTTCCCAGAAGAATCCTTCATGAGATCACAAGATACAATAGGA AAAGAAAAACTCTTCCATTTTACAGAAGAAACCCCTGAAATTCCCTCGGGCAACATTTCT TCCGGTTGGCCTGATTTTAATAGCAGTGACTATGAAACTACGTCTCAGCCATATTGGTGG GACAGTGCATCTGCAGCTCCTGAAAGTGAAGATGAATTTGTCAGCGTACTTCCCATGGAA TACGAAAATAACAGTACACTCAGTGAGACAGAGAAGTCAACATCAGGCTCTTTCTCCTTT TTCCCTGTGCAAATGATATTGACCTGGTTACCACCCAAACCACCCACTGCTTTTGATGGG TTCCATATCCATATTGAACGAGAAGAGAACTTTACTGAATATTTGATGGTGGATGAAGAA GCACATGAATTTGTTGCAGAACTGAAGGAACCTGGGAAATATAAGTTATCTGTGACAACC TTTAGTTCCTCAGGATCTTGTGAAACTCGAAAAAGTCAGTCAGCAAAATCACTCAGCTTT TATATCAGTCCTTCAGGAGAGTGGATTGAAGAACTGACCGAGAAGCCGCAGCACGTGAGT GTCCACGTTTTAAGCTCAACCACTGCCTTGATGTCCTGGACATCTTCCCAAGAGAACTAC AACAGCACCATTGTGTCTGTGGTGTCGCTGACCTGCCAGAAACAAAAGGAGAGCCAGAGG CTTGAAAAGCAGTACTGCACTCAGGTGAACTCAAGCAAACCTATTATTGAAAATCTGGTT CCTGGTGCCCAGTACCAGGTTGTAATATACCTAAGGAAAGGCCCTTTGATTGGACCACCT TCAGATCCTGTGACATTTGCTATTGTTCCCACAGGAATAAAGGATTTAATGCTCTATCCT TTGGGTCCTACGGCCGTGGTTCTGAGCTGGACCAGACCTTATTTAGGCGTGTTCAGAAAA TACGTGGTTGAAATGTTTTATTTCAACCCTGCTACAATGACATCAGAGTGGACCACCTAC TATGAAATAGCAGCAACTGTTTCCTTAACTGCATCCGTGAGAATAGCTAATCTGCTGCCA GCATGGTACTACAACTTCCGGGTTACCATGGTGACGTGGGGAGATCCAGAATTGAGCTGC TGTGACAGCTCTACCATCAGCTTCATAACAGCCCCAGTGGCTCCGGAAATCACTTCTGTG GAATATTTCAACAGTCTGTTATATATCAGTTGGACATATGGGGATGATACAACGGACTTG TCCCATTCTAGAATGCTTCACTGGATGGTGGTTGCAGAAGGAAAAAAGAAAATTAAAAAG AGTGTAACACGCAATGTCATGACTGCAATTCTCAGCTTGCCTCCAGGCGACATCTATAAC CTCTCAGTAACTGCTTGTACTGAAAGAGGAAGTAATACCTCCATGCTCCGCCTTGTCAAG CTAGAACCAGCTCCACCCAAATCACTCTTCGCAGTGAACAAAACCCAGACTTCAGTGACT TTGCTGTGGGTGGAAGAGGGAGTAGCTGATTTCTTTGAAGTTTTCTGTCAACAAGTTGGC TCCAGTCAGAAAACCAAACTTCAGGAACCAGTTGCTGTTTCTTCCCATGTCGTGACCATC TCCAGCCTTCTTCCTGCCACTGCCTACAATTGTAGTGTCACCAGCTTTAGCCATGACAGC CCCAGTGTCCCTACGTTCATAGCCGTCTCAACAATGGTTACAGAGATGAATCCCAATGTG GTAGTGATCTCCGTGCTGGCCATCCTTAGCACACTTTTAATTGGACTGTTGCTTGTTACC CTCATTATTCTTAGGAAAAAGCATCTGCAGATGGCTAGGGAGTGTGGAGCTGGTACATTT GTCAATTTTGCATCCTTAGAGAGGGATGGAAAGCTTCCATACAACTGGAGTAAAAATGGT TTAAAGAAGAGGAAACTGACAAACCCGGTTCAACTGGATGACTTTGATGCCTATATTAAG GATATGGCCAAAGACTCTGACTATAAATTTTCTCTTCAGTTTGAGGAGTTGAAATTGATT GGACTGGATATCCCACACTTTGCTGCAGATCTTCCACTGAATCGATGTAAAAACCGTTAC ACAAACATCCTACCATATGACTTCAGCCGTGTGAGATTAGTCTCCATGAATGAAGAGGAA GGTGCAGACTACATCAATGCCAACTATATTCCTGGATACAACTCACCCCAGGAGTATATT GCCACCCAGGGGCCACTGCCTGAAACCAGAAATGACTTCTGGAAGATGGTCCTGCAACAA AAGTCTCAGATTATTGTCATGCTCACTCAGTGTAATGAGAAAAGGAGGGTGAAATGTGAC CATTACTGGCCATTCACGGAAGAACCTATAGCCTATGGAGACATCACTGTGGAGATGATT TCAGAGGAAGAGCAGGACGACTGGGCCTGTAGACACTTCCGGATCAACTATGCTGACGAG ATGCAGGATGTGATGCATTTTAACTACACTGCATGGCCTGATCATGGTGTGCCCACAGCA AATGCTGCAGAAAGTATCCTGCAGTTTGTACACATGGTCCGACAGCAAGCTACCAAGAGC AAAGGTCCCATGATCATTCACTGCAGTGCTGGCGTGGGACGGACAGGAACATTCATTGCC CTGGACAGGCTCTTGCAGCACATTCGGGATCATGAGTTTGTTGACATCTTAGGGCTGGTG TCAGAAATGAGGTCATACCGGATGTCTATGGTACAGACAGAGGAGCAGTACATTTTTATC CATCAGTGTGTGCAACTGATGTGGATGAAGAAGAAGCAGCAGTTCTGCATCAGTGATGTC ATATACGAGAATGTTAGCAAGTCCTAG |
GenBank Gene ID | |
GeneCard ID | None |
GenAtlas ID | |
HGNC ID | HGNC:9678 |
Chromosome Location | 12 |
Locus | None |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Patulin |
154.121 |
||
Vanadyl sulfate |
165.013 |
||
Vanadium |
50.941 |