DNA-directed RNA polymerase I subunit RPA43

NameDNA-directed RNA polymerase I subunit RPA43
SynonymsTwist neighbor protein
Gene NameTWISTNB
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009195|DNA-directed RNA polymerase I subunit RPA43
MAAGCSEAPRPAAASDGSLVGQAGVLPCLELPTYAAACALVNSRYSCLVAGPHQRHIALS
PRYLNRKRTGIREQLDAELLRYSESLLGVPIAYDNIKVVGELGDIYDDQGHIHLNIEADF
VIFCPEPGQKLMGIVNKVSSSHIGCLVHGCFNASIPKPEQLSAEQWQTMEINMGDELEFE
VFRLDSDAAGVFCIRGKLNITSLQFKRSEVSEEVTENGTEEAAKKPKKKKKKKDPETYEV
DSGTTKLADDADDTPMEESALQNTNNANGIWEEEPKKKKKKKKHQEVQDQDPVFQGSDSS
GYQSDHKKKKKKRKHSEEAEFTPPLKCSPKRKGKSNFL
Number of residues338
Molecular Weight37432.025
Theoretical pINone
GO Classification
Functions
    DNA-directed RNA polymerase activity
Processes
    transcription initiation from RNA polymerase I promoter
gene expression
negative regulation of gene expression, epigenetic
regulation of gene expression, epigenetic
termination of RNA polymerase I transcription
transcription elongation from RNA polymerase I promoter
transcription from RNA polymerase I promoter
Components
    nucleolus
nucleoplasm
DNA-directed RNA polymerase I complex
microtubule cytoskeleton
nucleus
General FunctionDna-directed rna polymerase activity
Specific FunctionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ3B726
UniProtKB Entry NameRPA43_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0017716|DNA-directed RNA polymerase I subunit RPA43 (TWISTNB)
ATGGCTGCAGGTTGCTCAGAGGCGCCGCGGCCAGCGGCGGCTTCTGATGGGTCTCTGGTA
GGGCAGGCTGGCGTCCTGCCTTGCCTAGAGTTGCCGACTTATGCCGCTGCTTGTGCGCTG
GTGAACAGTCGCTACTCATGCCTGGTGGCCGGGCCGCACCAAAGGCACATCGCGCTGTCG
CCCCGCTACCTTAACAGGAAACGCACCGGCATTCGAGAACAGCTTGATGCGGAGCTCCTT
CGCTATTCTGAGAGCCTTTTAGGTGTCCCTATTGCATATGATAACATCAAAGTTGTGGGA
GAGCTTGGAGATATTTATGATGATCAAGGACACATTCATCTTAACATTGAAGCCGATTTT
GTTATTTTCTGCCCTGAACCAGGGCAGAAGCTTATGGGTATAGTTAATAAAGTGTCTTCT
AGCCACATTGGCTGTTTAGTACATGGGTGTTTCAATGCCTCCATTCCTAAACCTGAGCAG
TTGTCAGCTGAGCAGTGGCAAACCATGGAGATAAACATGGGTGATGAACTAGAATTTGAA
GTATTTCGTTTAGACTCAGATGCTGCTGGAGTATTCTGCATTCGGGGAAAACTAAATATC
ACAAGTTTACAATTCAAGCGCTCTGAAGTTTCTGAAGAAGTTACAGAAAATGGCACTGAG
GAAGCTGCTAAAAAACCTAAAAAGAAGAAAAAGAAGAAAGACCCAGAGACATATGAAGTG
GACAGTGGTACCACAAAGCTAGCAGATGATGCAGATGACACTCCAATGGAAGAGTCAGCC
CTGCAGAATACTAATAATGCGAATGGCATCTGGGAGGAGGAGCCAAAGAAAAAGAAGAAG
AAGAAAAAGCACCAGGAAGTTCAGGACCAGGACCCTGTTTTCCAAGGCAGTGACTCCAGT
GGTTACCAAAGTGACCATAAAAAGAAAAAAAAGAAAAGAAAACACAGTGAAGAGGCCGAA
TTTACCCCACCTTTGAAATGCTCACCAAAAAGAAAAGGGAAAAGTAATTTTCTTTAG
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:18027
Chromosome Location7
LocusNone
References
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