Putative histone H2B type 2-D

NamePutative histone H2B type 2-D
Synonyms
Gene NameHIST2H2BD
OrganismHuman
Amino acid sequence
>lcl|BSEQ0020841|Putative histone H2B type 2-D
MPEPAKFAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKRVHPDTGIWCKAM
GIMNSFLNDIFERIAGEASRLAHYNKRSTITSRRSRRPCACCCPASWPSTPCPRAPRRSP
STPAPSESLPGPGARSLPPSLPPRVAGCFVSKGSFQGHLTPLVK
Number of residues164
Molecular Weight18017.875
Theoretical pINone
GO Classification
Functions
    DNA binding
Processes

                

              
Components

                

                  
    nucleus
extracellular exosome
nucleosome

                

              

          		
      

      
General FunctionDna binding

      
Specific FunctionCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

      
Transmembrane Regions

      
GenBank Protein ID

      
UniProtKB IDQ6DRA6  

      
UniProtKB Entry NameH2B2D_HUMAN  

      
Cellular LocationNucleus

      
Gene sequence
None

      
GenBank Gene ID

      
GeneCard IDNone

      
GenAtlas ID

      
HGNC IDHGNC:20517  

      
Chromosome LocationNone

      
LocusNone

      
References
        
          
    
            
            
  1. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ: The human and mouse replication-dependent histone genes. Genomics. 2002 Nov;80(5):487-98.[12408966  ]
    2. 
            
            
  2. Braastad CD, Hovhannisyan H, van Wijnen AJ, Stein JL, Stein GS: Functional characterization of a human histone gene cluster duplication. Gene. 2004 Nov 10;342(1):35-40.[15527963  ]
    3. 
            
            
  3. Cheung WL, Ajiro K, Samejima K, Kloc M, Cheung P, Mizzen CA, Beeser A, Etkin LD, Chernoff J, Earnshaw WC, Allis CD: Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell. 2003 May 16;113(4):507-17.[12757711  ]
    4. 
            
            
  4. Golebiowski F, Kasprzak KS: Inhibition of core histones acetylation by carcinogenic nickel(II). Mol Cell Biochem. 2005 Nov;279(1-2):133-9.[16283522  ]
    5. 
            
            
  5. Tan M, Luo H, Lee S, Jin F, Yang JS, Montellier E, Buchou T, Cheng Z, Rousseaux S, Rajagopal N, Lu Z, Ye Z, Zhu Q, Wysocka J, Ye Y, Khochbin S, Ren B, Zhao Y: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell. 2011 Sep 16;146(6):1016-28. doi: 10.1016/j.cell.2011.08.008.[21925322  ]
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Related FRC

      

    

    
        

            FRCD ID
            Name
            Exact Mass
            
            Structure
        

        
        

        
        

            
                

                



F04252
                

            		
            


Nickelocene

            


188.883		
            
        

        
        

            
                

                



F02409
                

            		
            


Nickel chloride

            


129.593		
            
        

        
        

            
                

                



F03271
                

            		
            


Benzene

            


78.114		
            
        

        
        

            
                

                



F03310
                

            		
            


Nickel

            


58.693