Keratin-associated protein 5-2

NameKeratin-associated protein 5-2
SynonymsKAP5-8 KAP5.2 Keratin-associated protein 5-8 Keratin-associated protein 5.2 Keratin-associated protein 5.8 KRTAP5-8 KRTAP5.2 KRTAP5.8 Ultrahigh sulfur keratin-associated protein 5.2
Gene NameKRTAP5-2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013142|Keratin-associated protein 5-2
MGCCGCSRGCGSGCGGCGSSCGGCGSGCGGCGSGRGGCGSGCGGCSSSCGGCGSRCYVPV
CCCKPVCSWVPACSCTSCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGCSQSSCCK
PCCCSSGCGSSCCQSSCCKPCCCQSSCCVPVCCQSSCCKPCCCQSNCCVPVCCQCKI
Number of residues177
Molecular Weight16270.68
Theoretical pINone
GO Classification
Functions

                

              
Processes

                

                    

                

              
Components

                

                  
    keratin filament

                

              

          		
      

      
General FunctionNone

      
Specific FunctionIn the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

      
Transmembrane Regions

      
GenBank Protein ID

      
UniProtKB IDQ701N4  

      
UniProtKB Entry NameKRA52_HUMAN  

      
Cellular LocationNone

      
Gene sequence
>lcl|BSEQ0013143|Keratin-associated protein 5-2 (KRTAP5-2)
ATGGGCTGCTGTGGCTGCTCCAGAGGCTGTGGCTCCGGCTGTGGGGGCTGTGGCTCCAGC
TGTGGGGGTTGTGGCTCTGGCTGTGGGGGCTGTGGCTCCGGCCGTGGGGGCTGTGGCTCT
GGCTGTGGGGGCTGCAGCTCCAGCTGTGGGGGATGTGGCTCCAGATGTTATGTGCCTGTC
TGCTGCTGCAAGCCCGTGTGCTCCTGGGTGCCAGCCTGTTCCTGCACCAGCTGTGGCTCC
TGTGGGGGCTCCAAGGGGGGCTGTGGCTCCTGTGGGGGCTCCAAGGGGGGCTGTGGCTCC
TGTGGGGGTTCCAAGGGGGGCTGTGGTTCTTGTGGCTGCTCCCAGTCCAGCTGTTGTAAG
CCCTGTTGCTGCTCCTCAGGCTGTGGATCATCCTGCTGCCAGTCCAGCTGCTGCAAGCCC
TGCTGCTGCCAGTCCAGCTGCTGTGTCCCCGTGTGCTGCCAGTCCAGCTGCTGCAAGCCC
TGTTGCTGCCAGTCCAACTGTTGTGTCCCTGTGTGCTGCCAGTGTAAGATCTGA

      
GenBank Gene ID

      
GeneCard IDNone

      
GenAtlas ID

      
HGNC IDHGNC:23597  

      
Chromosome Location11

      
LocusNone

      
References
        
          
    
            
            
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334  ]
    2. 
            
            
  2. Yahagi S, Shibuya K, Obayashi I, Masaki H, Kurata Y, Kudoh J, Shimizu N: Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11. Biochem Biophys Res Commun. 2004 Jun 4;318(3):655-64.[15144888  ]
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Related FRC

      

    

    
        

            FRCD ID
            Name
            Exact Mass
            
            Structure
        

        
        

        
        

            
                

                



F05350
                

            		
            


D-Glucose

            


180.156