Kinesin-like protein KIF18B


NameKinesin-like protein KIF18B
Synonyms
Gene NameKIF18B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009139|Kinesin-like protein KIF18B
MSHPGVTTVMAVEDSTLQVVVRVRPPTPRELDSQRRPVVQVVDERVLVFNPEEPDGGFPG
LKWGGTHDGPKKKGKDLTFVFDRVFGEAATQQDVFQHTTHSVLDSFLQGYNCSVFAYGAT
GAGKTHTMLGREGDPGIMYLTTVELYRRLEARQQEKHFEVLISYQEVYNEQIHDLLEPKG
PLAIREDPDKGVVVQGLSFHQPASAEQLLEILTRGNRNRTQHPTDANATSSRSHAIFQIF
VKQQDRVPGLTQAVQVAKMSLIDLAGSERASSTHAKGERLREGANINRSLLALINVLNAL
ADAKGRKTHVPYRDSKLTRLLKDSLGGNCRTVMIAAISPSSLTYEDTYNTLKYADRAKEI
RLSLKSNVTSLDCHISQYATICQQLQAEVAALRKKLQVYEGGGQPPPQDLPGSPKSGPPP
EHLPSSPLPPHPPSQPCTPELPAGPRALQEESLGMEAQVERAMEGNSSDQEQSPEDEDEG
PAEEVPTQMPEQNPTHALPESPRLTLQPKPVVGHFSARELDGDRSKQLALKVLCVAQRQY
SLLQAANLLTPDMITEFETLQQLVQEEKIEPGAEALRTSGLARGAPLAQELCSESKPPGY
TGPVTRTMARRLSGPLHTLGIPPGPNCTPAQGSRWPMEKKRRRPSALEADSPMAPKRGTK
RQRQSFLPCLRRGSLPDTQPSQGPSTPKGERASSPCHSPRVCPATVIKSRVPLGPSAMQN
CSTPLALPTRDLNATFDLSEEPPSKPSFHECIGWDKIPQELSRLDQPFIPRAPVPLFTMK
GPKPTSSLPGTSACKKKRVASSSVSHGRSRIARLPSSTLKRPAGPLVLPELPLSPLCPSN
RRNGKDLIRVGRALSAGNGVTKVS
Number of residues864
Molecular Weight94222.305
Theoretical pINone
GO Classification
Functions
    motor activity
    ATP-dependent microtubule motor activity, plus-end-directed
    kinesin binding
    ATP binding
Processes
    cell division
    mitotic cell cycle
    microtubule depolymerization
    mitotic sister chromatid segregation
    microtubule-based movement
    regulation of cell division
Components
    astral microtubule
    microtubule end
    kinesin complex
    cytoplasm
    microtubule plus-end
    nucleus
General FunctionMotor activity
Specific FunctionIn complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ86Y91
UniProtKB Entry NameKI18B_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0021446|Kinesin-like protein KIF18B (KIF18B)
ATGGCAGTGGAGGACAGCACGCTGCAAGTAGTGGTACGGGTGCGGCCCCCCACCCCTCGG
GAGCTGGACAGTCAGCGGCGGCCAGTGGTTCAGGTGGTGGACGAGCGGGTGCTGGTGTTT
AACCCTGAGGAGCCCGATGGAGGGTTCCCTGGCCTGAAATGGGGTGGCACCCATGATGGC
CCCAAGAAGAAGGGCAAAGACCTGACGTTTGTCTTTGACCGGGTCTTTGGCGAGGCGGCC
ACCCAACAGGACGTGTTCCAGCACACCACGCACAGCGTCCTGGACAGCTTCCTCCAGGGC
TACAACTGCTCAGTGTTTGCCTACGGGGCCACCGGGGCTGGGAAGACACACACCATGCTG
GGAAGGGAGGGGGACCCCGGCATCATGTACCTGACCACCGTGGAACTGTACAGGCGCCTG
GAGGCCCGCCAGCAGGAGAAGCACTTCGAGGTGCTCATCAGCTACCAGGAGGTGTATAAT
GAACAGATCCATGACCTCCTGGAGCCCAAGGGGCCCCTTGCCATCCGCGAGGACCCCGAC
AAGGGGGTGGTGGTGCAAGGACTTTCTTTCCACCAGCCAGCCTCAGCCGAGCAGCTGCTG
GAGATACTGACCAGGGGGAACCGTAACCGCACGCAGCACCCCACTGATGCCAACGCGACT
TCCTCCCGCTCCCATGCCATCTTCCAGATCTTTGTGAAGCAGCAGGACCGGGTTCCAGGA
CTGACCCAGGCTGTCCAGGTGGCCAAGATGAGCCTGATTGACCTGGCTGGCTCAGAGCGG
GCATCCAGCACCCATGCGAAGGGGGAGCGGCTGCGGGAGGGGGCCAACATCAACCGCTCT
CTGCTGGCGCTCATCAACGTCCTCAATGCCTTGGCCGATGCAAAGGGCCGCAAGACCCAT
GTGCCCTACCGGGACAGCAAACTGACCCGCCTGCTCAAAGACTCCCTCGGGGGCAACTGC
CGCACAGTGATGATCGCTGCCATCAGCCCCTCCAGCCTGACCTACGAGGACACGTACAAC
ACCCTCAAATATGCCGACCGGGCCAAGGAGATCAGGCTCTCGCTGAAGAGCAATGTGACC
AGCCTGGACTGTCACATCAGCCAGTATGCTACCATCTGCCAACAGCTCCAGGCTGAGGTA
GCCGCTCTGAGGAAGAAGCTCCAAGTGTATGAGGGGGGAGGCCAGCCCCCACCACAGGAC
CTCCCAGGATCTCCCAAGTCGGGACCACCACCAGAACACCTTCCCAGCTCCCCCTTGCCA
CCCCACCCTCCCAGCCAGCCCTGCACCCCAGAGCTCCCTGCAGGGCCTAGAGCCCTTCAA
GAGGAGAGTCTGGGGATGGAGGCCCAGGTGGAGAGGGCCATGGAAGGGAACTCTTCAGAC
CAGGAGCAGTCCCCAGAGGATGAGGATGAAGGCCCAGCTGAGGAGGTTCCAACCCAGATG
CCAGAGCAGAACCCCACACATGCACTGCCAGAGTCCCCTCGCCTGACCCTGCAGCCCAAG
CCAGTCGTGGGCCACTTCTCAGCACGGGAACTGGATGGGGACCGTTCTAAGCAGTTGGCC
CTAAAGGTGCTGTGCGTTGCCCAGCGGCAGTACTCCCTGCTCCAAGCAGCCAACCTCCTG
ACGCCCGACATGATCACAGAGTTTGAGACCCTACAGCAGCTGGTGCAAGAGGAAAAAATT
GAGCCTGGGGCAGAGGCCTTGAGGACTTCAGGCCTGGCCAGGGGGGCACCTCTGGCTCAG
GAGCTGTGTTCAGAGTCAATCCCTGTGCCGTCTCCTCTCTGCCCAGAGCCTCCAGGATAC
ACTGGCCCTGTGACCCGGACTATGGCGAGGCGACTGAGTGGCCCCCTGCACACCCTGGGA
ATCCCGCCTGGACCCAACTGCACCCCAGCCCAGGGGTCCCGATGGCCCATGGAGAAGAAG
AGGAGGAGACCAAGCGCCTTGGAGGCAGACAGTCCCATGGCCCCAAAGCGGGGCACCAAG
CGCCAGCGCCAGTCCTTCCTGCCCTGCCTAAGGAGAGGGTCTCTGCCTGACACCCAACCT
TCACAGGGGCCCAGCACCCCCAAAGGAGAAAGGGCCTCCTCCCCCTGCCATTCCCCTCGC
GTTTGCCCAGCCACAGTCATCAAAAGCCGGGTGCCCCTGGGCCCTTCCGCCATGCAGAAC
TGCTCCACCCCGCTGGCTCTGCCCACTCGAGACCTCAATGCCACCTTTGATCTCTCTGAG
GAGCCTCCCTCAAAGCCCAGTTTCCATGAATGCATTGGCTGGGACAAAATACCCCAGGAG
CTGAGCAGGCTGGACCAGCCCTTCATCCCCAGGGCACCTGTGCCCCTGTTCACCATGAAG
GGCCCCAAGCCAACATCTTCCCTCCCTGGGACCTCTGCCTGCAAGAAGAAGCGCGTTGCG
AGTTCCTCAGTCTCCCATGGCCGCAGCCGCATCGCCCGCCTCCCCAGCAGCACTTTGAAG
AGGCCAGCTGGGCCCCTTGTACTCCCAGGTGACTGGCACTAG
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:27102
Chromosome Location17
LocusNone
References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]
  2. Tanenbaum ME, Macurek L, van der Vaart B, Galli M, Akhmanova A, Medema RH: A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. Curr Biol. 2011 Aug 23;21(16):1356-65. doi: 10.1016/j.cub.2011.07.017. Epub 2011 Aug 4.[21820309 ]
  3. Lee YM, Kim E, Park M, Moon E, Ahn SM, Kim W, Hwang KB, Kim YK, Choi W, Kim W: Cell cycle-regulated expression and subcellular localization of a kinesin-8 member human KIF18B. Gene. 2010 Oct 15;466(1-2):16-25. doi: 10.1016/j.gene.2010.06.007. Epub 2010 Jun 23.[20600703 ]
  4. Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature. 2006 Apr 20;440(7087):1045-9.[16625196 ]
  5. Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR 3rd: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. J Proteome Res. 2008 Mar;7(3):1346-51. doi: 10.1021/pr0705441. Epub 2008 Jan 26.[18220336 ]
  6. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007.[18691976 ]
  7. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31.[18669648 ]
  8. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475.[20068231 ]
  9. Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 2011 Mar 15;4(164):rs3. doi: 10.1126/scisignal.2001570.[21406692 ]

Related FRC


FRCD ID Name Exact Mass Structure



Acrylamide




71.079