Kinesin-like protein KIF18A

NameKinesin-like protein KIF18A
SynonymsMarrow stromal KIF18A MS-KIF18A
Gene NameKIF18A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017699|Kinesin-like protein KIF18A
MSVTEEDLCHHMKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDPKQEEVSFFHGKKTT
NQNVIKKQNKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKT
HTMLGSADEPGVMYLTMLHLYKCMDEIKEEKICSTAVSYLEVYNEQIRDLLVNSGPLAVR
EDTQKGVVVHGLTLHQPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQD
KTASINQNVRIAKMSLIDLAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKR
KNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLK
SNVLNVNNHITQYVKICNEQKAEILLLKEKLKAYEEQKAFTNENDQAKLMISNPQEKEIE
RFQEILNCLFQNREEIRQEYLKLEMLLKENELKSFYQQQCHKQIEMMCSEDKVEKATGKR
DHRLAMLKTRRSYLEKRREEELKQFDENTNWLHRVEKEMGLLSQNGHIPKELKKDLHCHH
LHLQNKDLKAQIRHMMDLACLQEQQHRQTEAVLNALLPTLRKQYCTLKEAGLSNAAFESD
FKEIEHLVERKKVVVWADQTAEQPKQNDLPGISVLMTFPQLGPVQPIPCCSSSGGTNLVK
IPTEKRTRRKLMPSPLKGQHTLKSPPSQSVQLNDSLSKELQPIVYTPEDCRKAFQNPSTV
TLMKPSSFTTSFQAISSNINSDNCLKMLCEVAIPHNRRKECGQEDLDSTFTICEDIKSSK
CKLPEQESLPNDNKDILQRLDPSSFSTKHSMPVPSMVPSYMAMTTAAKRKRKLTSSTSNS
SLTADVNSGFAKRVRQDNSSEKHLQENKPTMEHKRNICKINPSMVRKFGRNISKGNLR
Number of residues898
Molecular Weight102280.305
Theoretical pINone
GO Classification
Functions
    actin binding
ATP binding
ubiquitin binding
microtubule binding
microtubule plus-end binding
tubulin-dependent ATPase activity
ATP-dependent microtubule motor activity, plus-end-directed
Processes
    antigen processing and presentation of exogenous peptide antigen via MHC class II
mitotic metaphase plate congression
microtubule depolymerization
mitotic cell cycle
regulation of microtubule cytoskeleton organization
microtubule-based movement
male meiosis
mitotic sister chromatid segregation
blood coagulation
protein transport
small GTPase mediated signal transduction
seminiferous tubule development
Components
    kinetochore
cytosol
mitotic spindle midzone
cytoplasm
caveola
microtubule organizing center
microtubule cytoskeleton
nucleus
ruffle
kinetochore microtubule
kinesin complex
General FunctionUbiquitin binding
Specific FunctionMicrotubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ8NI77
UniProtKB Entry NameKI18A_HUMAN
Cellular LocationCell projection
Gene sequence
>lcl|BSEQ0017700|Kinesin-like protein KIF18A (KIF18A)
ATGTCTGTCACTGAGGAAGACCTGTGCCACCATATGAAAGTAGTAGTTCGTGTACGTCCG
GAAAACACTAAAGAAAAAGCAGCTGGATTTCATAAAGTGGTTCATGTTGTGGATAAACAT
ATCCTAGTTTTTGATCCCAAACAAGAAGAAGTCAGTTTTTTCCATGGAAAGAAAACTACA
AATCAAAATGTTATAAAGAAACAAAATAAGGATCTTAAATTTGTATTTGATGCTGTTTTT
GATGAAACGTCAACTCAGTCAGAAGTTTTTGAACACACTACTAAGCCAATTCTTCGTAGT
TTTTTGAATGGATATAATTGCACAGTACTTGCCTATGGTGCCACTGGTGCTGGGAAGACC
CACACTATGCTAGGATCAGCTGATGAACCTGGAGTGATGTATCTAACAATGTTACACCTT
TACAAATGCATGGATGAGATTAAAGAAGAGAAAATATGTAGTACTGCAGTTTCATATCTG
GAGGTATATAATGAACAGATTCGTGATCTCTTAGTAAATTCAGGGCCACTTGCTGTCCGG
GAAGATACCCAAAAAGGGGTGGTCGTTCATGGACTTACTTTACACCAGCCCAAATCCTCA
GAAGAAATTTTACATTTATTGGATAATGGAAACAAAAACAGGACACAACATCCCACTGAT
ATGAATGCCACATCTTCTCGTTCTCATGCTGTTTTCCAAATTTACTTGCGACAACAAGAC
AAAACAGCAAGTATCAATCAAAATGTCCGTATTGCCAAGATGTCACTCATTGACCTGGCA
GGATCTGAGCGAGCAAGTACTTCCGGTGCTAAGGGGACCCGATTTGTAGAAGGCACAAAT
ATTAATAGATCACTTTTAGCTCTTGGGAATGTCATCAATGCCTTAGCAGATTCAAAGAGA
AAGAATCAGCATATCCCTTACAGAAATAGTAAGCTTACTCGCTTGTTAAAGGATTCTCTT
GGAGGAAACTGTCAAACTATAATGATAGCTGCTGTTAGTCCTTCCTCTGTATTCTACGAT
GACACATATAACACTCTTAAGTATGCTAACCGGGCAAAGGACATTAAATCTTCTTTGAAG
AGCAATGTTCTTAATGTCAATAATCATATAACTCAATATGTAAAGATCTGTAATGAGCAG
AAGGCAGAGATTTTATTGTTAAAAGAAAAACTAAAAGCCTATGAAGAACAGAAAGCCTTC
ACTAATGAAAATGACCAAGCAAAGTTAATGATTTCAAACCCTCAGGAAAAAGAAATCGAA
AGGTTTCAAGAAATCCTGAACTGCTTGTTCCAGAATCGAGAAGAAATTAGACAAGAATAT
CTGAAGTTGGAAATGTTACTTAAAGAAAATGAACTTAAATCATTCTACCAACAACAGTGC
CATAAACAAATAGAAATGATGTGTTCTGAAGACAAAGTAGAAAAGGCCACTGGAAAACGA
GATCATAGACTTGCAATGTTGAAAACTCGTCGCTCCTACCTGGAGAAAAGGAGGGAGGAG
GAATTGAAGCAATTTGATGAGAATACTAATTGGCTCCATCGTGTCGAAAAAGAAATGGGA
CTCTTAAGTCAAAACGGTCATATTCCAAAGGAACTCAAGAAAGATCTTCATTGTCACCAT
TTGCACCTCCAGAACAAAGATTTGAAAGCACAAATTAGACATATGATGGATCTAGCTTGT
CTTCAGGAACAGCAACACAGGCAGACTGAAGCAGTATTGAATGCTTTACTTCCAACCCTA
AGAAAACAATATTGCACATTAAAAGAAGCCGGCCTGTCAAATGCTGCTTTTGAATCTGAC
TTCAAAGAGATCGAACATTTGGTAGAGAGGAAAAAAGTGGTAGTTTGGGCTGACCAAACT
GCCGAACAACCAAAGCAAAACGATCTACCAGGGATTTCTGTTCTTATGACCTTTCCACAA
CTTGGACCAGTTCAGCCTATTCCTTGTTGCTCATCTTCAGGTGGAACTAATCTGGTTAAG
ATTCCTACAGAAAAAAGAACTCGGAGAAAACTAATGCCATCTCCCTTGAAAGGACAGCAT
ACTCTAAAGTCTCCACCATCTCAAAGTGTGCAGCTCAATGATTCTCTTAGCAAAGAACTT
CAGCCTATTGTATATACACCAGAAGACTGTAGAAAAGCTTTTCAAAATCCGTCTACAGTA
ACCTTAATGAAACCATCATCATTTACTACAAGTTTTCAGGCTATCAGCTCAAACATAAAC
AGTGATAATTGTCTGAAAATGTTGTGTGAAGTAGCTATCCCTCATAATAGAAGAAAAGAA
TGTGGACAGGAGGACTTGGACTCTACATTTACTATATGTGAAGACATCAAGAGCTCGAAG
TGTAAATTACCCGAACAAGAATCACTACCAAATGATAACAAAGACATTTTACAACGGCTT
GATCCTTCTTCATTCTCAACTAAGCATTCTATGCCTGTACCAAGCATGGTGCCATCCTAC
ATGGCAATGACTACTGCTGCCAAAAGGAAACGGAAATTAACAAGTTCTACATCAAACAGT
TCGTTAACTGCAGACGTAAATTCTGGATTTGCCAAACGTGTTCGACAAGATAATTCAAGT
GAGAAGCACTTACAAGAAAACAAACCAACAATGGAACATAAAAGAAACATCTGTAAAATA
AATCCAAGCATGGTTAGAAAATTTGGAAGAAATATTTCAAAAGGAAATCTAAGATAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:29441
Chromosome Location11
LocusNone
References
  1. Luboshits G, Benayahu D: MS-KIF18A, new kinesin; structure and cellular expression. Gene. 2005 May 23;351:19-28.[15878648 ]
  2. Mayr MI, Hummer S, Bormann J, Gruner T, Adio S, Woehlke G, Mayer TU: The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression. Curr Biol. 2007 Mar 20;17(6):488-98. Epub 2007 Mar 8.[17346968 ]
  3. Luboshits G, Benayahu D: MS-KIF18A, a kinesin, is associated with estrogen receptor. J Cell Biochem. 2007 Feb 15;100(3):693-702.[17006958 ]
  4. Stumpff J, von Dassow G, Wagenbach M, Asbury C, Wordeman L: The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment. Dev Cell. 2008 Feb;14(2):252-62. doi: 10.1016/j.devcel.2007.11.014.[18267093 ]
  5. Zusev M, Benayahu D: New insights on cellular distribution, microtubule interactions and post-translational modifications of MS-KIF18A. J Cell Physiol. 2008 Dec;217(3):618-25. doi: 10.1002/jcp.21525.[18680169 ]
  6. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31.[18669648 ]
  7. Gardner MK, Odde DJ, Bloom K: Kinesin-8 molecular motors: putting the brakes on chromosome oscillations. Trends Cell Biol. 2008 Jul;18(7):307-10. doi: 10.1016/j.tcb.2008.05.003. Epub 2008 May 29.[18513970 ]
  8. Huang Y, Yao Y, Xu HZ, Wang ZG, Lu L, Dai W: Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E. Cell Cycle. 2009 Aug 15;8(16):2643-9. Epub 2009 Aug 29.[19625775 ]
  9. Zusev M, Benayahu D: The regulation of MS-KIF18A expression and cross talk with estrogen receptor. PLoS One. 2009 Jul 28;4(7):e6407. doi: 10.1371/journal.pone.0006407.[19636373 ]
  10. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475.[20068231 ]
  11. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A: Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome Res. 2001 Mar;11(3):422-35.[11230166 ]
  12. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]

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