Fas-binding factor 1

NameFas-binding factor 1
SynonymsALB FBF-1 KIAA1863 Protein albatross
Gene NameFBF1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009834|Fas-binding factor 1
MAPKTKKGCKVTLPEKPVKLASHTRDTTGVSQMFPSSKARTKSLLGDDVFSTMAGLEEAD
AEVSGISEADPQALLQAMKDLDGMDADILGLKKSNSAPSKKAAKDPGKGELPNHPKPAGG
AIPTKKSLPSPSSSGHQNRRFSSEDLEDPLRGLLSYDEGGITKQPPVTQSKTASDKSPST
VRDQGPSIPLTPGDTPIRKKEELLFDDGDDIMATLGFGDSPKAEKRQIGDQEGPRPARST
LDELLGRGMATKLLARPGTGEHREFKLDKKYQRPQDSEDMWGDEDFTFGAYQPTVVSSEG
RQSRRQSVSRFFADSGADPKGEPGSKQSPPMASSPIQPRKGGADWLGLKDEDLDLFPASP
TREAHRESSVPVTPSVPPPASQHSTPAGLPPSRAKPPTEGAGSPAKASQASKLRASKEEK
EDWLSHALSRKKSQGLAREQHAGTSEGLHLAGTAGHPPSGSQPLTSTQGLEHAAAGGSSG
TTARERPCVRPGVSGSPVTQNHAASALPTGSPKRGTAPGDLSATEPATCFPSTQKPTEPS
VPVQPLLPESLARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKL
ELERAQHELLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLS
QCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLKLLK
DREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQL
RALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRAL
EEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKER
AEREAERALQVDTQREGTLISLAKQAELKIRASELRAEEKQLAAERAALEQERQELRLEK
ERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLR
KQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQSALMPPAPTTRWCS
QPPTGLDPSPLHLHARLALLRHMAEQDRDFLENEQFFLETLKKGSYNLTSHSA
Number of residues1133
Molecular Weight125445.19
Theoretical pINone
GO Classification
Functions

                

              
Processes

                

                    
    cilium assembly
apical junction assembly
establishment of epithelial cell polarity
organelle organization

                

              
Components

                

                  
    centriole
ciliary transition fiber
cell junction
cytosol
centrosome
spindle pole

                

              

          		
      

      
General FunctionNone

      
Specific FunctionKeratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis.

      
Transmembrane Regions

      
GenBank Protein ID

      
UniProtKB IDQ8TES7  

      
UniProtKB Entry NameFBF1_HUMAN  

      
Cellular LocationCytoplasm

      
Gene sequence
>lcl|BSEQ0013939|Fas-binding factor 1 (FBF1)
ATGGCACCAAAAACCAAGAAAGGATGTAAAGTGACACTACCTGAGAAGCCTGTTAAACTA
GCTTCACATACCAGAGACACCACAGGTGTATCTCAGATGTTCCCTTCTTCAAAGGCGAGA
ACAAAGTCCCTCCTGGGTGATGATGTCTTCAGCACCATGGCAGGCCTGGAAGAAGCTGAT
GCTGAGGTTTCAGGTATCTCAGAGGCAGACCCACAGGCTCTGCTCCAGGCCATGAAGGAC
CTGGACGGCATGGATGCTGATATCTTAGGTCTGAAGAAATCTAATTCAGCCCCTAGCAAA
AAAGCTGCAAAGGACCCTGGGAAAGGAGAGCTGCCCAACCACCCCAAGCCTGCAGGGGGT
GCCATTCCCACCAAGAAGTCACTTCCGTCTCCCAGCAGCTCTGGGCATCAGAACAGGAGG
TTTTCCTCTGAAGACTTGGAAGACCCATTGAGAGGACTTCTCTCCTATGATGAAGGAGGA
ATCACCAAGCAGCCGCCTGTGACACAGAGTAAAACAGCTTCTGACAAGAGCCCCAGCACA
GTGAGAGATCAAGGTCCCTCTATTCCTCTAACTCCTGGGGACACCCCCATCCGAAAAAAA
GAAGAATTGTTGTTTGATGATGGGGATGACATCATGGCCACCTTGGGGTTTGGAGACAGC
CCCAAAGCAGAGAAGAGGCAGATAGGAGACCAGGAAGGGCCTCGCCCTGCTCGCTCCACG
CTGGATGAGCTGCTGGGTCGAGGCATGGCCACCAAACTCCTGGCCCGCCCGGGCACCGGG
GAGCACAGGGAGTTCAAGCTAGACAAGAAGTACCAGAGGCCACAGGACAGTGAAGATATG
TGGGGTGACGAGGACTTCACCTTTGGAGCCTATCAGCCCACTGTGGTCTCCTCTGAGGGC
CGGCAGTCCCGCCGGCAGTCTGTCAGGTTCTTCGCAGACAGTGGCGCAGACCCCAAGGGA
GAACCAGGCTCCAAACAGAGCCCTCCAATGGCTTCCAGCCCCATCCAGCCCAGGAAGGGA
GGAGCTGACTGGTTGGGCCTCAAGGACGAGGACTTGGACCTGTTCCCTGCCTCACCCACC
AGAGAGGCCCATCGGGAAAGTTCAGTGCCTGTCACGCCCTCAGTGCCTCCTCCTGCGAGC
CAGCACTCCACGCCAGCTGGGCTGCCCCCCTCCAGGGCAAAGCCACCAACTGAAGGTGCA
GGGTCCCCTGCCAAAGCCAGCCAGGCTTCCAAGCTGCGAGCCTCCAAGGAGGAGAAAGAG
GACTGGCTGAGCCATGCCCTGTCTCGGAAGAAGTCCCAAGGCCTGGCCAGAGAGCAGCAT
GCTGGGACCTCTGAGGGCCTGCATTTGGCGGGGACAGCGGGCCATCCCCCTTCTGGCAGC
CAACCTCTCACCAGCACACAAGGGCTTGAGCACGCAGCTGCTGGAGGGAGTTCTGGAACA
ACTGCACGAGAAAGACCGTGTGTCAGGCCTGGTGTCTCGGGGTCCCCTGTGACTCAGAAC
CATGCCGCCTCAGCACTCCCTACAGGTTCCCCAAAGAGGGGAACAGCCCCTGGAGACCTC
TCAGCCACTGAGCCTGCCACGTGTTTCCCGAGCACCCAGAAACCCACAGAGCCTTCCGTG
CCCGTCCAGCCCCTGCTCCCAGAGTCCCTGGCCCGGAGCCTGCTGCCGAGCACAGAATAC
CAGAAGCAGCTCCTGGCAGCACAGGTGCAACTTCAGTGCAGCCCCGCTGAGCTCCAGGCC
GAGCTGCTGCATAGCCAGGCCCGGCTGGCAGAGCTGGAGGCCCAGGTGCGGAAGCTGGAG
CTAGAACGGGCCCAGCATGAGCTGCTGCTGGGGAGTCTGCAGCAGCAGCACCAGGCAGAC
CTGGAGCTCATCGAGAGTGCACACAGAAGCCGCATCAAGGTGCTAGAAACATCGTACCAG
CAACGGGAGGAGCGGCTCCGGAGAGAGAACGAAGAGCTGTCAGCTCGGTATCTGTCGCAG
TGCCAGGAGGCCGAACAGGCCCGTGCTGAGCTTACGGCCCAGCACCAGCGGCGCTTGGCG
GCCATAGCGCAGGAGAAGGACCAGGAAATGGAGCGGCTCCGGGAGCTGCAGCGGGCGTCC
ATCCTAGACATGCGCAGAGACCACGAGGAGCAGCTGCAGCGGCTAAAGCTGCTGAAGGAC
CGAGAGGTCGATGCGGCCACCAGTGCCACCTCCCACACGCGGTCCCTGAATAGCATCATC
CACCAGATGGAGAAGTTCTCCAGCAGCCTGCACGAGTTGTCCTCCCGCGTGGAGGCCTCG
CACCTCACCACCTCCCAGGAGCGGGAGCTGGGGATCCGGCAGCGTGACGAGCAGCTGCGG
GCACTGCAGGAGCGGCTGGGCCAGCAGCAGCGGGACATGGAGGAGGAGCGGAGCCGGCAA
CAGGAGGTCATCGGGAAGATGGAGGCACGGCTGAATGAGCAGAGCCGGCTGCTGGAGCAG
GAACGCTGGCGGGTGACTGCCGAGCAGTCCAAGGCGGAGTCCATGCAGCGCGCCCTAGAG
GAGCAAAGGAAGGTCACGGCCCAGCAGATGGCCATGGAAAGGGCGGAGCTGGAACGGGCC
AAGAGCGCCTTGCTGGAGGAGCAGAAGTCTGTCATGCTCAAGTGCGGGGAGGAGCGGCGG
CGCCTGGCTGCCGAGTGGGCGGAGTTCTCCGCGCAGCAAAAGCTGAGTAAGGAGCGGGCC
GAGCGCGAGGCCGAGCGGGCATTGCAGGTGGACACCCAGCGGGAGGGCACCCTCATCAGC
CTGGCCAAGGAGCAGGCTGAGCTGAAGATCAGGGCCAGCGAGCTCCGGGCCGAGGAGAAG
CAGCTGGCAGCGGAGAGAGCAGCCCTGGAGCAGGAGCGGCAGGAGCTGCGGCTGGAGAAG
GAGAGGATCAACGCCACCGCCCTGCGTGTCAAGCTCCGCGCCGAGGAGGTGGAGAGCATG
AGCAAGGTGGCCTCCGAGAAGTACGAGGAGGGGGAGCGGGCATTGCGCGAGGCCCAGCAG
GTGCAGGCAGAGCAGCAGGCCCGGTTGCAGGCGGTGCAGCAACAGCAGGAGCGGCTGCGG
AAGCAGGAGCAGCACATGCACCAGGAGCATCTGAGTCTGGCCCAGCAGAGGCTGCAACTG
GACCGCGCACGACAGGACCTGCCCTCTAGCCTCGTGGGTCTGTTCCCCAGGGCCCAGGGC
CCTGCAGCCTCCAGCCAGAGTGCCCTCATGCCTCCTGCTCCCACCACCCGTTGGTGCAGC
CAGCCGCCAACTGGCCTGGACCCCAGCCCCTTGCACCTCCATGCCAGGCTGGCACTGCTG
AGGCACATGGCAGAGCAGGACCGTGACTTCTTGGAGAATGAACAGTTCTTCCTGGAGACC
CTGAAGAAAGGGTCCTACAATTTGACATCTCATTCAGCCTGA

      
GenBank Gene ID

      
GeneCard IDNone

      
GenAtlas ID

      
HGNC IDHGNC:24674  

      
Chromosome Location17

      
LocusNone

      
References
        
          
    
            
            
  1. Sugimoto M, Inoko A, Shiromizu T, Nakayama M, Zou P, Yonemura S, Hayashi Y, Izawa I, Sasoh M, Uji Y, Kaibuchi K, Kiyono T, Inagaki M: The keratin-binding protein Albatross regulates polarization of epithelial cells. J Cell Biol. 2008 Oct 6;183(1):19-28. doi: 10.1083/jcb.200803133.[18838552  ]
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  3. Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O: Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 2001 Apr 27;8(2):85-95.[11347906  ]
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  4. Schmidt T, Karsunky H, Frass B, Baum W, Denzel A, Moroy T: A novel protein (Fbf-1) that binds to CD95/APO-1/FAS and shows sequence similarity to trichohyalin and plectin. Biochim Biophys Acta. 2000 Sep 7;1493(1-2):249-54.[10978533  ]
    5. 
            
            
  5. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309.[19413330  ]
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  6. Jakobsen L, Vanselow K, Skogs M, Toyoda Y, Lundberg E, Poser I, Falkenby LG, Bennetzen M, Westendorf J, Nigg EA, Uhlen M, Hyman AA, Andersen JS: Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 2011 Apr 20;30(8):1520-35. doi: 10.1038/emboj.2011.63. Epub 2011 Mar 11.[21399614  ]
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  7. Tanos BE, Yang HJ, Soni R, Wang WJ, Macaluso FP, Asara JM, Tsou MF: Centriole distal appendages promote membrane docking, leading to cilia initiation. Genes Dev. 2013 Jan 15;27(2):163-8. doi: 10.1101/gad.207043.112.[23348840  ]
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  8. Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature. 2006 Apr 20;440(7087):1045-9.[16625196  ]
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  9. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334  ]
    10. 
            
          

        		
      

    

    


      
    
Related FRC

      

    

    
        

            FRCD ID
            Name
            Exact Mass
            
            Structure
        

        
        

        
        

            
                

                



F03271
                

            		
            


Benzene

            


78.114		
            
        

        
        

            
                

                



F03272
                

            		
            


Cadmium

            


112.414		
            
        

        
        

            
                

                



F03327
                

            		
            


Zinc

            


65.38		
            
        

        
        

            
                

                



F03371
                

            		
            


Copper

            


63.546		
            
        

        
        

            
                

                



F03381
                

            		
            


Chlordecone

            


490.609		
            
        

        
        

            
                

                



F03387
                

            		
            


Parathion

            


291.258		
            
        

        
        

            
                

                



F03413
                

            		
            


Phenol

            


94.113		
            
        

        
        

            
                

                



F03444
                

            		
            


4-Aminobiphenyl

            


169.227		
            
        

        
        

            
                

                



F03449
                

            		
            


Dichlorvos

            


220.97		
            
        

        
        

            
                

                



F02629
                

            		
            


Mercuric chloride

            


271.492		
            
        

        
        

            
                

                



F04221
                

            		
            


Thiomersal

            


404.811		
            
        

        
        

            
                

                



F04719
                

            		
            


Warfarin

            


308.333		
            
        

        
        

            
                

                



F04735
                

            		
            


Vitamin A

            


286.459		
            
        

        
        

            
                

                



F04755
                

            		
            


Imipramine

            


280.415		
            
        

        
        

            
                

                



F04769
                

            		
            


Diazepam

            


284.74		
            
        

        
        

            
                

                



F04982
                

            		
            


Dicumarol

            


336.299		
            
        

        
        

            
                

                



F05388
                

            		
            


Atrazine

            


215.685		
            
        

        
        

            
                

                



F05405
                

            		
            


Diazoxon

            


288.284		
            
        

        
        

            
                

                



F05461
                

            		
            


Quinone

            


108.096		
            
        

        
        

            
                

                



F05615
                

            		
            


Paraoxon

            


275.197