Histone-lysine N-methyltransferase SETD7

NameHistone-lysine N-methyltransferase SETD7
Synonyms2.1.1.43 H3-K4-HMTase SETD7 Histone H3-K4 methyltransferase SETD7 KIAA1717 KMT7 Lysine N-methyltransferase 7 SET domain-containing protein 7 SET7 SET7/9 SET9
Gene NameSETD7
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004957|Histone-lysine N-methyltransferase SETD7
MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLE
GYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCW
IYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRP
HFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNT
VMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFT
PNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAF
QATQQK
Number of residues366
Molecular Weight40720.595
Theoretical pI4.25
GO Classification
Functions
    p53 binding
histone-lysine N-methyltransferase activity
chromatin binding
protein-lysine N-methyltransferase activity
Processes
    chromatin modification
chromatin organization
heterochromatin organization
peptidyl-lysine dimethylation
cellular response to DNA damage stimulus
peptidyl-lysine monomethylation
positive regulation of transcription, DNA-templated
regulation of histone H3-K9 methylation
transcription, DNA-templated
response to ethanol
Components
    chromosome
nucleolus
nucleoplasm
General FunctionProtein-lysine n-methyltransferase activity
Specific FunctionHistone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ8WTS6
UniProtKB Entry NameSETD7_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0011800|Histone-lysine N-methyltransferase SETD7 (SETD7)
ATGGATAGCGACGACGAGATGGTGGAGGAGGCGGTGGAAGGGCACCTGGACGATGACGGA
TTACCGCACGGGTTCTGCACAGTCACCTACTCCTCCACAGACAGATTTGAGGGGAACTTT
GTTCACGGAGAAAAGAACGGACGGGGGAAGTTCTTCTTCTTTGATGGCAGCACCCTGGAG
GGGTATTATGTGGATGATGCCTTGCAGGGCCAGGGAGTTTACACTTACGAAGATGGGGGA
GTTCTCCAGGGCACGTATGTAGACGGAGAGCTGAACGGTCCAGCCCAGGAATATGACACA
GATGGGAGACTGATCTTCAAGGGGCAGTATAAAGATAACATTCGTCATGGAGTGTGCTGG
ATATATTACCCAGATGGAGGAAGCCTTGTAGGAGAAGTAAATGAAGATGGGGAGATGACT
GGAGAGAAGATAGCCTATGTGTACCCTGATGAGAGGACCGCACTTTATGGGAAATTTATT
GATGGAGAGATGATAGAAGGCAAACTGGCTACCCTTATGTCCACTGAAGAAGGGAGGCCT
CACTTTGAACTGATGCCTGGAAATTCAGTGTACCACTTTGATAAGTCGACTTCATCTTGC
ATTTCTACCAATGCTCTTCTTCCAGATCCTTATGAATCAGAAAGGGTTTATGTTGCTGAA
TCTCTTATTTCCAGTGCTGGAGAAGGACTTTTTTCAAAGGTAGCTGTGGGACCTAATACT
GTTATGTCTTTTTATAATGGAGTTCGAATTACACACCAAGAGGTTGACAGCAGGGACTGG
GCCCTTAATGGGAACACCCTCTCCCTTGATGAAGAAACGGTCATTGATGTGCCTGAGCCC
TATAACCACGTATCCAAGTACTGTGCCTCCTTGGGACACAAGGCAAATCACTCCTTCACT
CCAAACTGCATCTACGATATTGGCCAGAAGAATCACCTGGGAACGTGTAAAAGAAGCAGA
TTTGGGGCTCCACTCCCAAAGATCCCACATCTGGATCAAGCGCCCTGGGTAGAACACAGA
AAAGCTGGCATTCCTCTTTATAGTGCAGCCCAAGGACTGATGCTCATAATGATGTTCGTG
AGTAATTAA
GenBank Gene IDAF448510
GeneCard IDNone
GenAtlas IDSETD7
HGNC IDHGNC:30412
Chromosome Location4
Locus4q28
References
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  13. Jacobs SA, Harp JM, Devarakonda S, Kim Y, Rastinejad F, Khorasanizadeh S: The active site of the SET domain is constructed on a knot. Nat Struct Biol. 2002 Nov;9(11):833-8.[12389038 ]
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  15. Kwon T, Chang JH, Kwak E, Lee CW, Joachimiak A, Kim YC, Lee J, Cho Y: Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet. EMBO J. 2003 Jan 15;22(2):292-303.[12514135 ]
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