Aquaporin-3
Name | Aquaporin-3 |
---|---|
Synonyms | AQP-3 Aquaglyceroporin-3 |
Gene Name | AQP3 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0008810|Aquaporin-3 MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTIN LAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVF GLYYDAIWHFADNQLFVSGPNGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVD PYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQ HWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENVKLAHVKHKEQI |
Number of residues | 292 |
Molecular Weight | 31543.605 |
Theoretical pI | None |
GO Classification |
Functions
glycerol channel activity water channel activity urea transmembrane transporter activity transporter activity Processes
transmembrane transport ion transmembrane transport cellular water homeostasis response to calcium ion urea transmembrane transport transport excretion renal water absorption positive regulation of immune system process renal water homeostasis regulation of keratinocyte differentiation water transport response to vitamin D response to retinoic acid odontogenesis Components
integral component of plasma membrane basolateral plasma membrane cytoplasm cell-cell junction nucleus plasma membrane integral component of membrane |
General Function | Water channel activity |
Specific Function | Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity). |
Transmembrane Regions | 29-49 54-74 110-130 158-178 189-209 245-265 |
GenBank Protein ID | |
UniProtKB ID | Q92482 |
UniProtKB Entry Name | AQP3_HUMAN |
Cellular Location | Basolateral cell membrane |
Gene sequence | >lcl|BSEQ0017599|Aquaporin-3 (AQP3) ATGGGTCGACAGAAGGAGCTGGTGTCCCGCTGCGGGGAGATGCTCCACATCCGCTACCGG CTGCTCCGACAGGCGCTGGCCGAGTGCCTGGGGACCCTCATCCTGGTGATGTTTGGCTGT GGCTCCGTGGCCCAGGTTGTGCTCAGCCGGGGCACCCACGGTGGTTTCCTCACCATCAAC CTGGCCTTTGGCTTTGCTGTCACTCTGGGCATCCTCATCGCTGGCCAGGTCTCTGGGGCC CACCTGAACCCTGCCGTGACCTTTGCCATGTGCTTCCTGGCTCGTGAGCCCTGGATCAAG CTGCCCATCTACACCCTGGCACAGACGCTGGGAGCCTTCTTGGGTGCTGGAATAGTTTTT GGGCTGTATTATGATGCAATCTGGCACTTCGCCGACAACCAGCTTTTTGTTTCGGGCCCC AATGGCACAGCCGGCATCTTTGCTACCTACCCCTCTGGACACTTGGATATGATCAATGGC TTCTTTGACCAGTTCATAGGCACAGCCTCCCTTATCGTGTGTGTGCTGGCCATTGTTGAC CCCTACAACAACCCCGTCCCCCGAGGCCTGGAGGCCTTCACCGTGGGCCTGGTGGTCCTG GTCATTGGCACCTCCATGGGCTTCAACTCCGGCTATGCCGTCAACCCTGCCCGGGACTTT GGCCCCCGCCTTTTTACAGCCCTTGCGGGCTGGGGCTCTGCAGTCTTCACGACCGGCCAG CATTGGTGGTGGGTGCCCATCGTGTCCCCACTCCTGGGCTCCATTGCGGGTGTCTTCGTG TACCAGCTGATGATCGGCTGCCACCTGGAGCAGCCCCCACCCTCCAACGAGGAAGAGAAT GTGAAGCTGGCCCATGTGAAGCACAAGGAGCAGATCTGA |
GenBank Gene ID | |
GeneCard ID | None |
GenAtlas ID | |
HGNC ID | HGNC:636 |
Chromosome Location | 9 |
Locus | None |
References |
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