Receptor-type tyrosine-protein phosphatase U

NameReceptor-type tyrosine-protein phosphatase U
Synonyms3.1.3.48 FMI hPTP-J Pancreatic carcinoma phosphatase 2 PCP-2 PCP2 Protein-tyrosine phosphatase J Protein-tyrosine phosphatase pi Protein-tyrosine phosphatase receptor omicron PTP pi PTP-J PTP-RO PTPRO R-PTP-psi R-PTP-U Receptor-type protein-tyrosine phosphatase psi
Gene NamePTPRU
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008993|Receptor-type tyrosine-protein phosphatase U
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT
RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY
VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI
SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT
YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS
LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ
TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR
RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP
LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG
LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC
IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYS
YYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRS
GGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYES
FFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIA
TQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTE
TLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGP
IVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDA
ILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALL
PRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPD
FWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARV
FRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHC
LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
EGLESR
Number of residues1446
Molecular Weight162422.095
Theoretical pINone
GO Classification
Functions
    protein tyrosine phosphatase activity
beta-catenin binding
transmembrane receptor protein tyrosine phosphatase activity
Processes
    protein dephosphorylation
organ regeneration
cell adhesion
single organismal cell-cell adhesion
peptidyl-tyrosine dephosphorylation
canonical Wnt signaling pathway
cell differentiation
protein localization to cell surface
negative regulation of cell proliferation
response to glucocorticoid
transmembrane receptor protein tyrosine phosphatase signaling pathway
negative regulation of cell migration
homotypic cell-cell adhesion
Components
    cell-cell junction
plasma membrane
integral component of plasma membrane
General FunctionTransmembrane receptor protein tyrosine phosphatase activity
Specific FunctionTyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.
Transmembrane Regions750-770
GenBank Protein ID
UniProtKB IDQ92729
UniProtKB Entry NamePTPRU_HUMAN
Cellular LocationCell junction
Gene sequence
>lcl|BSEQ0013553|Receptor-type tyrosine-protein phosphatase U (PTPRU)
ATGGCCCGTGCCCAGGCGCTCGTGCTGGCACTCACCTTCCAGCTCTGCGCGCCGGAGACC
GAGACTCCGGCAGCTGGCTGCACCTTCGAGGAGGCAAGTGACCCAGCAGTGCCCTGCGAG
TACAGCCAGGCCCAGTACGATGACTTCCAGTGGGAGCAAGTGCGAATCCACCCTGGCACC
CGGGCACCTGCGGACCTGCCCCACGGCTCCTACTTGATGGTCAACACTTCCCAGCATGCC
CCAGGCCAGCGAGCCCATGTCATCTTCCAGAGCCTGAGCGAGAATGATACCCACTGTGTG
CAGTTCAGCTACTTCCTGTACAGCCGGGACGGGCACAGCCCGGGCACCCTGGGCGTCTAC
GTGCGCGTTAATGGGGGCCCCCTGGGCAGTGCTGTGTGGAATATGACTGGATCCCACGGC
CGTCAGTGGCACCAGGCTGAGCTGGCTGTCAGCACTTTCTGGCCCAATGAATATCAGGTG
CTGTTTGAGGCCCTCATCTCCCCAGACCGCAGGGGCTACATGGGCCTAGATGACATCCTG
CTTCTCAGCTACCCCTGCGCAAAGGCCCCACACTTCTCCCGCCTGGGCGACGTGGAGGTC
AACGCGGGCCAGAACGCGTCGTTCCAGTGCATGGCCGCGGGCAGAGCGGCCGAGGCCGAA
CGCTTCCTCTTGCAACGGCAGAGCGGGGCGCTGGTGCCGGCGGCGGGCGTGCGGCACATC
AGCCACCGGCGCTTCCTGGCCACTTTCCCGCTGGCTGCCGTGAGCCGCGCCGAGCAGGAC
CTGTACCGCTGTGTGTCCCAGGCCCCGCGCGGCGCGGGCGTCTCTAACTTCGCGGAGCTC
ATCGTCAAGGAGCCCCCAACTCCCATCGCGCCCCCACAGCTGCTGCGTGCTGGCCCCACC
TACCTCATCATCCAGCTCAACACCAACTCCATCATTGGCGACGGGCCGATCGTGCGCAAG
GAGATTGAGTACCGCATGGCGCGCGGGCCCTGGGCTGAGGTGCACGCCGTCAGCCTGCAG
ACCTACAAGCTGTGGCACCTCGACCCCGACACAGAGTATGAGATCAGCGTGCTGCTCACG
CGTCCCGGAGACGGCGGCACTGGCCGCCCTGGGCCACCCCTCATCAGCCGCACCAAATGC
GCAGAGCCCATGAGGGCCCCCAAAGGCCTGGCTTTTGCTGAGATCCAGGCCCGTCAGCTG
ACCCTGCAGTGGGAACCACTGGGCTACAACGTGACGCGTTGCCACACCTATACTGTGTCG
CTGTGCTATCACTACACCCTGGGCAGCAGCCACAACCAGACCATCCGAGAGTGTGTGAAG
ACAGAGCAAGGTGTCAGCCGCTACACCATCAAGAACCTGCTGCCCTATCGGAACGTTCAC
GTGAGGCTTGTCCTCACTAACCCTGAGGGGCGCAAAGAGGGCAAGGAGGTCACTTTCCAG
ACGGATGAGGATGTGCCCAGTGGGATTGCAGCCGAGTCCCTGACCTTCACTCCACTGGAG
GACATGATCTTCCTCAAGTGGGAGGAGCCCCAGGAGCCCAATGGTCTCATCACCCAGTAT
GAGATCAGCTACCAGAGCATCGAGTCATCAGACCCGGCAGTGAACGTGCCAGGCCCACGA
CGTACCATCTCCAAGCTCCGCAATGAGACCTACCATGTCTTCTCCAACCTGCACCCAGGC
ACCACCTACCTGTTCTCCGTGCGGGCCCGCACAGGCAAAGGCTTCGGCCAGGCGGCACTC
ACTGAGATAACCACTAACATCTCTGCTCCCAGCTTTGATTATGCCGACATGCCGTCACCC
CTGGGCGAGTCTGAGAACACCATCACCGTGCTGCTGAGGCCGGCACAGGGCCGCGGTGCG
CCCATCAGTGTGTACCAGGTGATTGTGGAGGAGGAGCGGGCGCGGAGGCTGCGGCGGGAG
CCAGGTGGACAGGACTGCTTCCCAGTGCCATTGACCTTCGAGGCGGCGCTGGCCCGAGGC
CTGGTGCACTACTTCGGGGCCGAACTGGCGGCCAGCAGTCTACCTGAGGCCATGCCCTTT
ACCGTGGGTGACAACCAGACCTACCGAGGCTTCTGGAACCCACCACTTGAGCCTAGGAAG
GCCTATCTCATCTACTTCCAGGCAGCAAGCCACCTGAAGGGGGAGACCCGGCTGAATTGC
ATCCGCATTGCCAGGAAAGCTGCCTGCAAGGAAAGCAAGCGGCCCCTGGAGGTGTCCCAG
AGATCGGAGGAGATGGGGCTTATCCTGGGCATCTGTGCAGGGGGGCTTGCTGTCCTCATC
CTTCTCCTGGGTGCCATCATTGTCATCATCCGCAAAGGGAAGCCGGTGAACATGACCAAG
GCCACCGTCAACTACCGCCAGGAGAAGACACACATGATGAGCGCCGTGGACCGCAGCTTC
ACAGACCAGAGCACCCTGCAGGAGGACGAGCGGCTGGGCCTGTCCTTCATGGACACCCAT
GGCTACAGCACCCGGGGAGACCAGCGCAGCGGTGGGGTCACTGAGGCCAGCAGCCTCCTG
GGGGGCTCCCCGAGGCGTCCCTGTGGCCGGAAGGGCTCCCCATACCACACGGGGCAGCTG
CACCCTGCGGTGCGTGTCGCAGACCTTCTGCAGCACATCAACCAGATGAAGACGGCCGAG
GGTTACGGCTTCAAGCAGGAGTATGAGAGCTTCTTTGAAGGCTGGGACGCCACAAAGAAG
AAAGACAAGGTCAAGGGCAGCCGGCAGGAGCCAATGCCTGCCTATGATCGGCACCGAGTG
AAACTGCACCCGATGCTGGGAGACCCCAATGCCGACTACATTAATGCCAACTACATAGAT
GGTTACCACAGGTCAAACCACTTCATAGCCACTCAAGGGCCGAAGCCTGAGATGGTCTAT
GACTTCTGGCGTATGGTGTGGCAGGAGCACTGTTCCAGCATCGTCATGATCACCAAGCTG
GTCGAGGTGAAATGCTCACGGTACTGGCCGGAGGACTCAGACACCTACGGGGACATCAAG
ATTATGCTGGTGAAGACAGAGACCCTGGCTGAGTATGTCGTGCGCACTTTTGCCCTGGAG
CGGAGAGGCTACTCTGCCCGGCACGAGGTCCGCCAGTTCCACTTCACAGCGTGGCCAGAG
CATGGCGTCCCCTACCATGCCACGGGGCTGCTGGCTTTCATCCGGCGCGTGAAGGCCTCC
ACCCCACCTGATGCCGGGCCCATTGTCATCCACTGCAGCGCGGGCACCGGCCGCACAGGT
TGCTATATCGTCCTGGATGTGATGCTGGACATGGCAGAGTGTGAGGGCGTCGTGGACATT
TACAACTGTGTGAAGACTCTCTGCTCCCGGCGTGTCAACATGATCCAGACTGAGGAGCAG
TACATCTTCATTCATGATGCAATCCTGGAGGCCTGCCTGTGTGGGGAGACCACCATCCCT
GTCAGTGAGTTCAAGGCCACCTACAAGGAGATGATCCGCATTGATCCTCAGAGTAATTCC
TCCCAGCTGCGGGAAGAGTTCCAGACGCTGAACTCGGTCACCCCGCCGCTGGACGTGGAG
GAGTGCAGCATCGCCCTGTTGCCCCGGAACCGCGACAAGAACCGCAGCATGGACGTCCTG
CCGCCCGACCGCTGCCTGCCCTTCCTCATCTCCACTGATGGGGACTCCAACAACTACATT
AATGCAGCCCTGACTGACAGCTACACACGGAGTGCGGCCTTCATCGTGACCCTGCACCCG
CTGCAGAGCACCACGCCCGACTTCTGGCGGCTGGTCTACGATTACGGGTGCACCTCCATC
GTCATGCTCAACCAGCTGAACCAGTCCAACTCCGCCTGGCCCTGCCTGCAGTACTGGCCA
GAGCCAGGCCGGCAGCAATATGGCCTCATGGAGGTGGAGTTTATGTCGGGCACAGCTGAT
GAAGACTTAGTGGCTCGAGTCTTCCGGGTGCAGAACATCTCTCGGTTGCAGGAGGGGCAC
CTGCTGGTGCGGCACTTCCAGTTCCTGCGCTGGTCTGCATACCGGGACACACCTGACTCC
AAGAAGGCCTTCTTGCACCTGCTGGCTGAGGTGGACAAGTGGCAGGCCGAGAGTGGGGAT
GGGCGCACCATCGTGCACTGCCTAAACGGGGGAGGACGCAGCGGCACCTTCTGCGCCTGC
GCCACGGTCCTGGAGATGATCCGCTGCCACAACTTGGTGGACGTTTTCTTTGCTGCCAAA
ACCCTCCGGAACTACAAACCCAACATGGTGGAGACCATGGATCAGTACCACTTTTGCTAC
GATGTGGCCCTGGAGTACTTGGAGGGGCTGGAGTCAAGATAG
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:9683
Chromosome Location1
LocusNone
References
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