Estrogen receptor beta


NameEstrogen receptor beta
SynonymsER-beta ESTRB NR3A2 Nuclear receptor subfamily 3 group A member 2
Gene NameESR2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001580|Estrogen receptor beta
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
Number of residues530
Molecular Weight59215.765
Theoretical pI8.55
GO Classification
Functions
    enzyme binding
    receptor antagonist activity
    transcription coactivator activity
    zinc ion binding
    core promoter sequence-specific DNA binding
    estrogen receptor activity
    steroid hormone receptor activity
    estrogen response element binding
    DNA binding
    transcription factor activity, sequence-specific DNA binding
    steroid binding
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Processes
    cell-cell signaling
    negative regulation of cell growth
    extracellular negative regulation of signal transduction
    gene expression
    positive regulation of sequence-specific DNA binding transcription factor activity
    transcription initiation from RNA polymerase II promoter
    signal transduction
    intracellular estrogen receptor signaling pathway
    regulation of transcription, DNA-templated
    positive regulation of transcription, DNA-templated
    negative regulation of transcription from RNA polymerase II promoter
Components
    mitochondrion
    nucleoplasm
    extracellular region
    nucleus
General FunctionZinc ion binding
Specific FunctionNuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
Transmembrane Regions
GenBank Protein ID2911152
UniProtKB IDQ92731
UniProtKB Entry NameESR2_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0020485|Estrogen receptor beta (ESR2)
ATGGATATAAAAAACTCACCATCTAGCCTTAATTCTCCTTCCTCCTACAACTGCAGTCAA
TCCATCTTACCCCTGGAGCACGGCTCCATATACATACCTTCCTCCTATGTAGACAGCCAC
CATGAATATCCAGCCATGACATTCTATAGCCCTGCTGTGATGAATTACAGCATTCCCAGC
AATGTCACTAACTTGGAAGGTGGGCCTGGTCGGCAGACCACAAGCCCAAATGTGTTGTGG
CCAACACCTGGGCACCTTTCTCCTTTAGTGGTCCATCGCCAGTTATCACATCTGTATGCG
GAACCTCAAAAGAGTCCCTGGTGTGAAGCAAGATCGCTAGAACACACCTTACCTGTAAAC
AGAGAGACACTGAAAAGGAAGGTTAGTGGGAACCGTTGCGCCAGCCCTGTTACTGGTCCA
GGTTCAAAGAGGGATGCTCACTTCTGCGCTGTCTGCAGCGATTACGCATCGGGATATCAC
TATGGAGTCTGGTCGTGTGAAGGATGTAAGGCCTTTTTTAAAAGAAGCATTCAAGGACAT
AATGATTATATTTGTCCAGCTACAAATCAGTGTACAATCGATAAAAACCGGCGCAAGAGC
TGCCAGGCCTGCCGACTTCGGAAGTGTTACGAAGTGGGAATGGTGAAGTGTGGCTCCCGG
AGAGAGAGATGTGGGTACCGCCTTGTGCGGAGACAGAGAAGTGCCGACGAGCAGCTGCAC
TGTGCCGGCAAGGCCAAGAGAAGTGGCGGCCACGCGCCCCGAGTGCGGGAGCTGCTGCTG
GACGCCCTGAGCCCCGAGCAGCTAGTGCTCACCCTCCTGGAGGCTGAGCCGCCCCATGTG
CTGATCAGCCGCCCCAGTGCGCCCTTCACCGAGGCCTCCATGATGATGTCCCTGACCAAG
TTGGCCGACAAGGAGTTGGTACACATGATCAGCTGGGCCAAGAAGATTCCCGGCTTTGTG
GAGCTCAGCCTGTTCGACCAAGTGCGGCTCTTGGAGAGCTGTTGGATGGAGGTGTTAATG
ATGGGGCTGATGTGGCGCTCAATTGACCACCCCGGCAAGCTCATCTTTGCTCCAGATCTT
GTTCTGGACAGGGATGAGGGGAAATGCGTAGAAGGAATTCTGGAAATCTTTGACATGCTC
CTGGCAACTACTTCAAGGTTTCGAGAGTTAAAACTCCAACACAAAGAATATCTCTGTGTC
AAGGCCATGATCCTGCTCAATTCCAGTATGTACCCTCTGGTCACAGCGACCCAGGATGCT
GACAGCAGCCGGAAGCTGGCTCACTTGCTGAACGCCGTGACCGATGCTTTGGTTTGGGTG
ATTGCCAAGAGCGGCATCTCCTCCCAGCAGCAATCCATGCGCCTGGCTAACCTCCTGATG
CTCCTGTCCCACGTCAGGCATGCGAGGGCAGAAAAGGCCTCTCAAACACTCACCTCATTT
GGAATGAAGATGGAGACTCTTTTGCCTGAAGCAACGATGGAGCAGTGA
GenBank Gene IDAB006590
GeneCard IDNone
GenAtlas IDESR2
HGNC IDHGNC:3468
Chromosome Location14
Locus14q23.2
References
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Related FRC


FRCD ID Name Exact Mass Structure



Celecoxib




381.373



Estriol




288.387



Kaempferol




286.239



Masoprocol




302.37



4-Nonylphenol




220.356



Eugenol




164.2



Biochanin A




284.267



Flavone




222.243



Cadmium




112.414



Trichloroethylene




131.38



Hexachlorobutadiene




260.744



Heptachlor




373.3



1,2-Dichloroethane




98.954



Chlorobenzene




112.556



1,2,3-Trichlorobenzene




181.44



1,4-Dichlorobenzene




146.998



Pendimethalin




281.312



Telodrin




411.73



1,1-Dichloropropene




110.965



2,3-Dichloropropene




110.965



Ethylparaben




166.176



Butylparaben




194.23



Progesterone




314.469



Ethinyl Estradiol




296.41



Estrone




270.372



Quercetin




302.238



Apigenin




270.24



5,7-Dihydroxyflavone




254.241



Chloroform




119.369



Clofenotane




354.476



Aroclor 1254




326.422



Aroclor 1260




360.864



Dieldrin




380.895



Chlordane




409.758



Aroclor 1248




291.98



Toxaphene




411.774



Tetrachloroethylene




165.822



1,2-Dibromoethane




187.862



3,3'-Dichlorobenzidine




253.126



Endrin




380.895



Pentachlorophenol




266.323



Aroclor 1016




257.538



Methoxychlor




345.644



1,1-Dichloroethene




96.938



Dichloromethane




84.927



2,4,6-Trichlorophenol




197.439



Hexachlorobenzene




284.766



Ethion




384.5



1,1,1-Trichloroethane




133.396



Chlorpyrifos




350.575



Chlordecone




490.609



Dicofol




370.475



1,1,2,2-Tetrachloroethane




167.838



1,1-Dichloroethane




98.954



1,1,2-Trichloroethane




133.396



Hexachlorocyclopentadiene




272.755



1,2-Diphenylhydrazine




184.242



1,2-Dichlorobenzene




146.998



Chloroethane




64.512



1,2,4-Trichlorobenzene




181.44



2,4-Dichlorophenol




162.997



2,4,5-Trichlorophenol




197.439



Dichlorvos




220.97



2-Chlorophenol




128.555



Phenanthrene




178.234



Dibromochloromethane




208.277



Biphenyl




154.212



2-Chlorobiphenyl




188.654



3-Chlorobiphenyl




188.654



4-Chlorobiphenyl




188.654



2,2'-Dichlorobiphenyl




223.096



2,3-Dichlorobiphenyl




223.096



2,3'-Dichlorobiphenyl




223.096



2,4-Dichlorobiphenyl




223.096



2,4'-Dichlorobiphenyl




223.096



2,5-Dichlorobiphenyl




223.096



2,6-Dichlorobiphenyl




223.096



3,3'-Dichlorobiphenyl




223.096



3,4-Dichlorobiphenyl




223.096



3,4'-Dichlorobiphenyl




223.096



3,5-Dichlorobiphenyl




223.096



4,4'-Dichlorobiphenyl




223.096



2,2',3-Trichlorobiphenyl




257.538



2,2',4-Trichlorobiphenyl




257.538



2,2',5-Trichlorobiphenyl




257.538



2,2',6-Trichlorobiphenyl




257.538



2,3,3'-Trichlorobiphenyl




257.538



2,3,4-Trichlorobiphenyl




257.538



2,3,4'-Trichlorobiphenyl




257.538



2,3,5-Trichlorobiphenyl




257.538



2,3,6-Trichlorobiphenyl




257.538



2,3',4-Trichlorobiphenyl




257.538



2,3',5-Trichlorobiphenyl




257.538



2,3',6-Trichlorobiphenyl




257.538



2,4,4'-Trichlorobiphenyl




257.538



2,4,5-Trichlorobiphenyl




257.538



2,4,6-Trichlorobiphenyl




257.538



2,4',5-Trichlorobiphenyl




257.538



2,4',6-Trichlorobiphenyl




257.538



2,3',4'-Trichlorobiphenyl




257.538



2,3',5'-Trichlorobiphenyl




257.538



3,3',4-Trichlorobiphenyl




257.538



3,4,4'-Trichlorobiphenyl




257.538



3,4,5-Tricholobiphenyl




257.538



3,4',5-Trichlorobiphenyl




257.538



2,2',3,3'-Tetrachlorobiphenyl




291.98



2,2',3,4-Tetrachlorobiphenyl




291.98



2,2',3,4'-Tetrachlorobiphenyl




291.98



2,2',3,5-Tetrachlorobiphenyl




291.98



2,2',3,6-Tetrachlorobiphenyl




291.98



2,2',4,5-Tetrachlorobiphenyl




291.98



2,2',4,5'-Tetrachlorobiphenyl




291.98



2,2',4,6-Tetrachlorobiphenyl




291.98



2,2',4,6'-Tetrachlorobiphenyl




291.98



2,2',5,5'-Tetrachlorobiphenyl




291.98



2,2',5,6'-Tetrachlorobiphenyl




291.98



2,2',6,6'-Tetrachlorobiphenyl




291.98



2,3,3',4-Tetrachlorobiphenyl




291.98



2,3,3',4'-Tetrachlorobiphenyl




291.98



2,3,3',5-Tetrachlorobiphenyl




291.98



2,3,3',5'-Tetrachlorobiphenyl




291.98



2,3,3',6-Tetrachlorobiphenyl




291.98



2,3,4,4'-Tetrachlorobiphenyl




291.98



2,3,4,5-Tetrachlorobiphenyl




291.98



2,3,4,6-Tetrachlorobiphenyl




291.98



2,3,4',5-Tetrachlorobiphenyl




291.98



2,3,4',6-Tetrachlorobiphenyl




291.98



2,3,5,6-Tetrachlorobiphenyl




291.98



2,3',4,4'-Tetrachlorobiphenyl




291.98



2,3',4,5-Tetrachlorobiphenyl




291.98



2,3',4,5'-Tetrachlorobiphenyl




291.98



2,3',4,6-Tetrachlorobiphenyl




291.98



2,3',4',5-Tetrachlorobiphenyl




291.98



2,3',4',6-Tetrachlorobiphenyl




291.98



2,3',5,5'-Tetrachlorobiphenyl




291.98



2,3',5',6-Tetrachlorobiphenyl




291.98



2,4,4',5-Tetrachlorobiphenyl




291.98



2,4,4',6-Tetrachlorobiphenyl




291.98



2,3',4',5'-Tetrachlorobiphenyl




291.98



3,3',4,4'-Tetrachlorobiphenyl




291.98



3,3',4,5-Tetrachlorobiphenyl




291.98



3,3',4,5'-Tetrachlorobiphenyl




291.98



3,4,4',5-Tetrachlorobiphenyl




291.98



2,2',3,3',5-Pentachlorobiphenyl




326.422



2,2',3,3',6-Pentachlorobiphenyl




326.422



2,2',3,4,4'-Pentachlorobiphenyl




326.422



2,2',3,4,5-Pentachlorobiphenyl




326.422



2,2',3,4,5'-Pentachlorobiphenyl




326.422



2,2',3,4,6-Pentachlorobiphenyl




326.422



2,2',3,4,6'-Pentachlorobiphenyl




326.422



2,2',3,4',5-Pentachlorobiphenyl




326.422



2,2',3,4',6-Pentachlorobiphenyl




326.422



2,2',3,5,5'-Pentachlorobiphenyl




326.422



2,2',3,5,6-Pentachlorobiphenyl




326.422



2,2',3,5,6'-Pentachlorobiphenyl




326.422



2,2',3,5',6-Pentachlorobiphenyl




326.422



2,2',3,6,6'-Pentachlorobiphenyl




326.422



2,2',3,4',5'-Pentachlorobiphenyl




326.422



2,2',3,4',6'-Pentachlorobiphenyl




326.422



2,2',4,4',5-Pentachlorobiphenyl




326.422



2,2',4,4',6-Pentachlorobiphenyl




326.422



2,2',4,5,5'-Pentachlorobiphenyl




326.422



2,2',4,5,6'-Pentachlorobiphenyl




326.422



2,2',4,5',6-Pentachlorobiphenyl




326.422



2,2',4,6,6'-Pentachlorobiphenyl




326.422



2,3,3',4,4'-Pentachlorobiphenyl




326.422



2,3,3',4,5-Pentachlorobiphenyl




326.422



2,3,3',4',5-Pentachlorobiphenyl




326.422



2,3,3',4,5'-Pentachlorobiphenyl




326.422



2,3,3',4,6-Pentachlorobiphenyl




326.422



2,3,3',4',6-Pentachlorobiphenyl




326.422



2,3,3',5,5'-Pentachlorobiphenyl




326.422



2,3,3',5,6-Pentachlorobiphenyl




326.422



2,3,3',5',6-Pentachlorobiphenyl




326.422



2,3,4,4',5-Pentachlorobiphenyl




326.422



2,3,4,4',6-Pentachlorobiphenyl




326.422



2,3,4,5,6-Pentachlorobiphenyl




326.422



2,3,4',5,6-Pentachlorobiphenyl




326.422



2,3',4,4',5-Pentachlorobiphenyl




326.422



2,3',4,4',6-Pentachlorobiphenyl




326.422



2,3',4,5,5'-Pentachlorobiphenyl




326.422



2,3',4,5',6-Pentachlorobiphenyl




326.422



2,3,3',4',5'-Pentachlorobiphenyl




326.422



2,3',4,4',5'-Pentachlorobiphenyl




326.422



2,3',4',5,5'-Pentachlorobiphenyl




326.422



2,3',4',5',6-Pentachlorobiphenyl




326.422



3,3',4,4',5-Pentachlorobiphenyl




326.422



3,3',4,5,5'-Pentachlorobiphenyl




326.422



2,2',3,3',4,5-Hexachlorobiphenyl




360.864



2,2',3,3',4,5'-Hexachlorobiphenyl




360.864



2,2',3,3',4,6-Hexachlorobiphenyl




360.864



2,2',3,3',4,6'-Hexachlorobiphenyl




360.864



2,2',3,3',5,5'-Hexachlorobiphenyl




360.864



2,2',3,3',5,6-Hexachlorobiphenyl




360.864



2,2',3,3',5,6'-Hexachlorobiphenyl




360.864



2,2',3,3',6,6'-Hexachlorobiphenyl




360.864



2,2',3,4,4',5-Hexachlorobiphenyl




360.864



2,2',3,4,4',5'-Hexachlorobiphenyl




360.864



2,2',3,4,4',6-Hexachlorobiphenyl




360.864



2,2',3,4,4',6'-Hexachlorobiphenyl




360.864



2,2',3,4,5,5'-Hexachlorobiphenyl




360.864



2,2',3,4,5,6-Hexachlorobiphenyl




360.864



2,2',3,4,5,6'-Hexachlorobiphenyl




360.864



2,2',3,4,5',6-Hexachlorobiphenyl




360.864



2,2',3,4,6,6'-Hexachlorobiphenyl




360.864



2,2',3,4',5,5'-Hexachlorobiphenyl




360.864



2,2',3,4',5,6-Hexachlorobiphenyl




360.864



2,2',3,4',5,6'-Hexachlorobiphenyl




360.864



2,2',3,4',5',6-Hexachlorobiphenyl




360.864



2,2',3,4',6,6'-Hexachlorobiphenyl




360.864



2,2',3,5,5',6-Hexachlorobiphenyl




360.864



2,2',3,5,6,6'-Hexachlorobiphenyl




360.864



2,2',4,4',5,5'-Hexachlorobiphenyl




360.864



2,2',4,4',5,6'-Hexachlorobiphenyl




360.864



2,2',4,4',6,6'-Hexachlorobiphenyl




360.864



2,3,3',4,4',5-Hexachlorobiphenyl




360.864



2,3,3',4,4',5'-Hexachlorobiphenyl




360.864



2,3,3',4,4',6-Hexachlorobiphenyl




360.864



2,3,3',4,5,5'-Hexachlorobiphenyl




360.864



2,3,3',4,5,6-Hexachlorobiphenyl




360.864



2,3,3',4,5',6-Hexachlorobiphenyl




360.864



2,3,3',4',5,5'-Hexachlorobiphenyl




360.864



2,3,3',4',5',6-Hexachlorobiphenyl




360.864



2,3,3',5,5',6-Hexachlorobiphenyl




360.864



2,3,4,4',5,6-Hexachlorobiphenyl




360.864



2,3',4,4',5,5'-Hexachlorobiphenyl




360.864



2,3',4,4',5',6-Hexachlorobiphenyl




360.864



2,2',3,3',4,4',5-Heptachlorobiphenyl




395.306



3,3',4,4',5,5'-Hexachlorobiphenyl




360.864



2,2',3,3',4,4',6-Heptachlorobiphenyl




395.306



2,2',3,3',4,5,5'-Heptachlorobiphenyl




395.306



2,2',3,3',4,5,6-Heptachlorobiphenyl




395.306



2,2',3,3',4,5,6'-Heptachlorobiphenyl




395.306



2,2',3,3',4,5',6-Heptachlorobiphenyl




395.306



2,2',3,3',4,6,6'-Heptachlorobiphenyl




395.306



2,2',3,3',4,5',6'-Heptachlorobiphenyl




395.306



2,2',3,3',5,5',6-Heptachlorobiphenyl




395.306



2,2',3,3',5,6,6'-Heptachlorobiphenyl




395.306



2,2',3,4,4',5,5'-Heptachlorobiphenyl




395.306



2,2',3,4,4',5,6-Heptachlorobiphenyl




395.306



2,2',3,4,4',5,6'-Heptachlorobiphenyl




395.306



2,2',3,4,4',5',6-Heptachlorobiphenyl




395.306



2,2',3,4,4',6,6'-Heptachlorobiphenyl




395.306



2,2',3,4,5,5',6-Heptachlorobiphenyl




395.306



2,2',3,4,5,6,6'-Heptachlorobiphenyl




395.306



2,2',3,4',5,5',6-Heptachlorobiphenyl




395.306



2,2',3,4',5,6,6'-Heptachlorobiphenyl




395.306



2,3,3',4,4',5,5'-Heptachlorobiphenyl




395.306



2,3,3',4,4',5,6-Heptachlorobiphenyl




395.306



2,3,3',4,4',5',6-Heptachlorobiphenyl




395.306



2,3,3',4,5,5',6-Heptachlorobiphenyl




395.306



2,2',3,3',4,4',5,5'-Octachlorobiphenyl




429.748



2,2',3,3',4,4',5,6-Octachlorobiphenyl




429.748



2,2',3,3',4,4',5,6'-Octachlorobiphenyl




429.748



2,2',3,3',4,4',6,6'-Octachlorobiphenyl




429.748



2,2',3,3',4,5,5',6-Octachlorobiphenyl




429.748



2,2',3,3',4,5,5',6'-Octachlorobiphenyl




429.748



2,2',3,3',4,5,6,6'-Octachlorobiphenyl




429.748



2,2',3,3',4,5',6,6'-Octachlorobiphenyl




429.748



2,2',3,3',5,5',6,6'-Octachlorobiphenyl




429.748



2,2',3,4,4',5,5',6-Octachlorobiphenyl




429.748



2,2',3,4,4',5,6,6'-Octachlorobiphenyl




429.748



2,3,3',4,4',5,5',6-Octachlorobiphenyl




429.748



2,2',3,3',4,4',5,5',6-Nonachlorobiphenyl




464.19



2,2',3,3',4,4',5,6,6'-Nonachlorobiphenyl




464.19



2,2',3,3',4,5,5',6,6'-Nonachlorobiphenyl




464.19



Decachlorobiphenyl




498.632



Methiochlor




377.766



Chlorbenzylate




325.185



Bisphenol A




228.291



1,3,5-Trichlorobenzene




181.44



Imidacloprid




255.662



Fipronil




437.141



Dichlorprop




235.06



Dicamba




221.033



Alachlor




269.769



Acetochlor




269.769



Mirex




545.51



Isodrin




364.896



Fenvalerate




419.905



Amidochlor




296.795



Butachlor




311.85



(±)-Metalaxyl




279.336



Metolachlor




283.796



Propachlor




211.689



1,2-Dichloropropene




110.965



3,3-Dichloropropene




110.965



4-Bromobiphenyl Ether




249.107



Cannabielsoin




330.468



Cercosporamide




331.28



Taziprinone




385.508



4-Ethylphenol




122.167



Methyldopa




211.217



(S,E)-Zearalenone




318.369



Alternariol




258.229



Emodin




270.24



Cyanazine




240.695



Vinclozolin




286.108



Equol




242.274



Genistein




270.24



Daidzein




254.241



O-Desmethylangolensin




258.273



Benzophenone




182.222



Propylparaben




180.203



Testosterone




288.4



Fenbuconazole




336.823



Estradiol




272.388



Diethylstilbestrol




268.356



Dihydrotestosterone




290.447