Histone deacetylase 2

NameHistone deacetylase 2
Synonyms3.5.1.98 HD2
Gene NameHDAC2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004647|Histone deacetylase 2
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
Number of residues488
Molecular Weight55363.855
Theoretical pI5.75
GO Classification
Functions
    chromatin binding
transcription factor binding
histone deacetylase activity
deacetylase activity
enzyme binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
sequence-specific DNA binding
NF-kappaB binding
core promoter binding
protein deacetylase activity
RNA polymerase II repressing transcription factor binding
poly(A) RNA binding
Processes
    response to lipopolysaccharide
epidermal cell differentiation
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of epithelial to mesenchymal transition
hair follicle placode formation
negative regulation of peptidyl-lysine acetylation
negative regulation of transcription from RNA polymerase II promoter
eyelid development in camera-type eye
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
cardiac muscle hypertrophy
negative regulation of dendritic spine development
response to cocaine
histone H3 deacetylation
positive regulation of tyrosine phosphorylation of Stat3 protein
response to hyperoxia
negative regulation of MHC class II biosynthetic process
positive regulation of interleukin-1 production
positive regulation of oligodendrocyte differentiation
histone H4 deacetylation
histone deacetylation
behavioral response to ethanol
negative regulation of apoptotic process
chromatin organization
odontogenesis of dentin-containing tooth
positive regulation of receptor biosynthetic process
negative regulation of cell cycle
neurotrophin TRK receptor signaling pathway
transcription, DNA-templated
positive regulation of proteolysis
circadian regulation of gene expression
positive regulation of transcription from RNA polymerase II promoter
cellular response to hydrogen peroxide
negative regulation of gene expression, epigenetic
negative regulation of neuron projection development
gene expression
positive regulation of cell proliferation
regulation of gene expression, epigenetic
negative regulation of DNA binding
positive regulation of collagen biosynthetic process
blood coagulation
response to nicotine
cellular response to heat
cellular response to dopamine
positive regulation of tumor necrosis factor production
ATP-dependent chromatin remodeling
embryonic digit morphogenesis
dendrite development
cellular response to retinoic acid
response to amphetamine
chromatin remodeling
response to drug
response to caffeine
cellular response to transforming growth factor beta stimulus
fungiform papilla formation
maintenance of chromatin silencing
Components
    NuRD complex
Sin3 complex
cytoplasm
protein complex
nuclear chromatin
nucleoplasm
ESC/E(Z) complex
nucleus
General FunctionTranscription factor binding
Specific FunctionResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
Transmembrane Regions
GenBank Protein ID1667394
UniProtKB IDQ92769
UniProtKB Entry NameHDAC2_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0016767|Histone deacetylase 2 (HDAC2)
ATGGCGTACAGTCAAGGAGGCGGCAAAAAAAAAGTCTGCTACTACTACGACGGTGATATT
GGAAATTATTATTATGGACAGGGTCATCCCATGAAGCCTCATAGAATCCGCATGACCCAT
AACTTGCTGTTAAATTATGGCTTATACAGAAAAATGGAAATATATAGGCCCCATAAAGCC
ACTGCCGAAGAAATGACAAAATATCACAGTGATGAGTATATCAAATTTCTACGGTCAATA
AGACCAGATAACATGTCTGAGTATAGTAAGCAGATGCAGAGATTTAATGTTGGAGAAGAT
TGTCCAGTGTTTGATGGACTCTTTGAGTTTTGTCAGCTCTCAACTGGCGGTTCAGTTGCT
GGAGCTGTGAAGTTAAACCGACAACAGACTGATATGGCTGTTAATTGGGCTGGAGGATTA
CATCATGCTAAGAAATCAGAAGCATCAGGATTCTGTTACGTTAATGATATTGTGCTTGCC
ATCCTTGAATTACTAAAGTATCATCAGAGAGTCTTATATATTGATATAGATATTCATCAT
GGTGATGGTGTTGAAGAAGCTTTTTATACAACAGATCGTGTAATGACGGTATCATTCCAT
AAATATGGGGAATACTTTCCTGGCACAGGAGACTTGAGGGATATTGGTGCTGGAAAAGGC
AAATACTATGCTGTCAATTTTCCAATGAGAGATGGTATAGATGATGAGTCATATGGGCAG
ATATTTAAGCCTATTATCTCAAAGGTGATGGAGATGTATCAACCTAGTGCTGTGGTATTA
CAGTGTGGTGCAGACTCATTATCTGGTGATAGACTGGGTTGTTTCAATCTAACAGTCAAA
GGTCATGCTAAATGTGTAGAAGTTGTAAAAACTTTTAACTTACCATTACTGATGCTTGGA
GGAGGTGGCTACACAATCCGTAATGTTGCTCGATGTTGGACATATGAGACTGCAGTTGCC
CTTGATTGTGAGATTCCCAATGAGTTGCCATATAATGATTACTTTGAGTATTTTGGACCA
GACTTCAAACTGCATATTAGTCCTTCAAACATGACAAACCAGAACACTCCAGAATATATG
GAAAAGATAAAACAGCGTTTGTTTGAAAATTTGCGCATGTTACCTCATGCACCTGGTGTC
CAGATGCAAGCTATTCCAGAAGATGCTGTTCATGAAGACAGTGGAGATGAAGATGGAGAA
GATCCAGACAAGAGAATTTCTATTCGAGCATCAGACAAGCGGATAGCTTGTGATGAAGAA
TTCTCAGATTCTGAGGATGAAGGAGAAGGAGGTCGAAGAAATGTGGCTGATCATAAGAAA
GGAGCAAAGAAAGCTAGAATTGAAGAAGATAAGAAAGAAACAGAGGACAAAAAAACAGAC
GTTAAGGAAGAAGATAAATCCAAGGACAACAGTGGTGAAAAAACAGATACCAAAGGAACC
AAATCAGAACAGCTCAGCAACCCCTGA
GenBank Gene IDU31814
GeneCard IDNone
GenAtlas IDHDAC2
HGNC IDHGNC:4853
Chromosome Location6
Locus6q21
References
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