Bcl2-associated agonist of cell death
Name | Bcl2-associated agonist of cell death |
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Synonyms | BAD BBC6 Bcl-2-binding component 6 Bcl-2-like protein 8 Bcl-xL/Bcl-2-associated death promoter Bcl2 antagonist of cell death Bcl2-L-8 BCL2L8 |
Gene Name | BAD |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0006675|Bcl2-associated agonist of cell death MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSH HGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDE FVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ |
Number of residues | 168 |
Molecular Weight | 18391.765 |
Theoretical pI | 7.19 |
GO Classification |
Functions
cysteine-type endopeptidase activator activity involved in apoptotic process protein kinase binding lipid binding phospholipid binding Processes
response to amino acid cellular process regulating host cell cycle in response to virus response to progesterone apoptotic process positive regulation of neuron death response to ethanol positive regulation of mitochondrial membrane potential positive regulation of cysteine-type endopeptidase activity involved in apoptotic process fibroblast growth factor receptor signaling pathway positive regulation of insulin secretion involved in cellular response to glucose stimulus apoptotic signaling pathway glucose catabolic process glucose homeostasis positive regulation of autophagy neurotrophin TRK receptor signaling pathway positive regulation of apoptotic process by virus cellular response to chromate epidermal growth factor receptor signaling pathway cellular response to nicotine response to calcium ion positive regulation of B cell differentiation activation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of proteolysis positive regulation of type B pancreatic cell development innate immune response response to testosterone response to glucocorticoid positive regulation of T cell differentiation intrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway response to oleic acid intrinsic apoptotic signaling pathway in response to DNA damage extrinsic apoptotic signaling pathway cytokine-mediated signaling pathway extrinsic apoptotic signaling pathway via death domain receptors positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway suppression by virus of host apoptotic process type B pancreatic cell proliferation positive regulation of apoptotic process ADP metabolic process response to drug ATP metabolic process pore complex assembly release of cytochrome c from mitochondria Fc-epsilon receptor signaling pathway positive regulation of epithelial cell proliferation response to glucose activation of cysteine-type endopeptidase activity extrinsic apoptotic signaling pathway in absence of ligand cellular response to mechanical stimulus phosphatidylinositol-mediated signaling cellular response to lipid programmed cell death positive regulation of release of cytochrome c from mitochondria positive regulation of glucokinase activity response to estradiol cellular response to hypoxia regulation of mitochondrial membrane permeability positive regulation of insulin secretion response to hydrogen peroxide negative regulation of cytolysis Components
mitochondrial outer membrane cytosol mitochondrion |
General Function | Protein kinase binding |
Specific Function | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. |
Transmembrane Regions | |
GenBank Protein ID | |
UniProtKB ID | Q92934 |
UniProtKB Entry Name | BAD_HUMAN |
Cellular Location | Mitochondrion outer membrane |
Gene sequence | >lcl|BSEQ0021355|Bcl2-associated agonist of cell death (BAD) ATGTTCCAGATCCCAGAGTTTGAGCCGAGTGAGCAGGAAGACTCCAGCTCTGCAGAGAGG GGCCTGGGCCCCAGCCCCGCAGGGGACGGGCCCTCAGGCTCCGGCAAGCATCATCGCCAG GCCCCAGGCCTCCTGTGGGACGCCAGTCACCAGCAGGAGCAGCCAACCAGCAGCAGCCAT CATGGAGGCGCTGGGGCTGTGGAGATCCGGAGTCGCCACAGCTCCTACCCCGCGGGGACG GAGGACGACGAAGGGATGGGGGAGGAGCCCAGCCCCTTTCGGGGCCGCTCGCGCTCGGCG CCCCCCAACCTCTGGGCAGCACAGCGCTATGGCCGCGAGCTCCGGAGGATGAGTGACGAG TTTGTGGACTCCTTTAAGAAGGGACTTCCTCGCCCGAAGAGCGCGGGCACAGCAACGCAG ATGCGGCAAAGCTCCAGCTGGACGCGAGTCTTCCAGTCCTGGTGGGATCGGAACTTGGGC AGGGGAAGCTCCGCCCCCTCCCAGTGA |
GenBank Gene ID | U66879 |
GeneCard ID | None |
GenAtlas ID | BAD |
HGNC ID | HGNC:936 |
Chromosome Location | 11 |
Locus | 11q13.1 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
(-)-Gossypol |
518.562 |