Histone H2B type 1-A


NameHistone H2B type 1-A
SynonymsHistone H2B, testis Testis-specific histone H2B TSH2B TSH2B.1
Gene NameHIST1H2BA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013507|Histone H2B type 1-A
MPEVSSKGATISKKGFKKAVVKTQKKEGKKRKRTRKESYSIYIYKVLKQVHPDTGISSKA
MSIMNSFVTDIFERIASEASRLAHYSKRSTISSREIQTAVRLLLPGELAKHAVSEGTKAV
TKYTSSK
Number of residues127
Molecular Weight14167.38
Theoretical pINone
GO Classification
Functions
    DNA binding
Processes
    chromatin organization
    positive regulation of binding
    nucleosome assembly
    nucleosome disassembly
    inflammatory response
    mononuclear cell migration
    spermatogenesis, exchange of chromosomal proteins
    plasminogen activation
Components
    nuclear nucleosome
    nucleosome
    nucleus
    nucleoplasm
    extrinsic component of plasma membrane
    nuclear chromosome, telomeric region
General FunctionDna binding
Specific FunctionVariant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ96A08
UniProtKB Entry NameH2B1A_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013508|Histone H2B type 1-A (HIST1H2BA)
ATGCCGGAGGTGTCATCTAAAGGTGCTACCATTTCCAAGAAGGGCTTTAAGAAAGCTGTC
GTTAAGACCCAGAAAAAGGAAGGCAAAAAGCGCAAGAGGACCCGTAAGGAGAGTTATTCT
ATTTACATCTACAAAGTGCTAAAGCAGGTCCATCCGGACACTGGCATCTCTTCGAAAGCT
ATGAGCATTATGAATTCCTTCGTCACTGATATCTTTGAGCGTATAGCGAGCGAGGCATCA
CGTTTGGCTCACTACAGCAAGCGCTCCACCATTTCTTCCAGAGAGATTCAGACAGCAGTG
CGCTTGCTACTGCCGGGAGAGCTGGCTAAACATGCTGTGTCTGAGGGCACCAAGGCTGTC
ACTAAGTACACCAGCTCCAAGTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:18730
Chromosome Location6
LocusNone
References
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  2. Zalensky AO, Siino JS, Gineitis AA, Zalenskaya IA, Tomilin NV, Yau P, Bradbury EM: Human testis/sperm-specific histone H2B (hTSH2B). Molecular cloning and characterization. J Biol Chem. 2002 Nov 8;277(45):43474-80. Epub 2002 Sep 3.[12213818 ]
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