Lethal(3)malignant brain tumor-like protein 3

NameLethal(3)malignant brain tumor-like protein 3
SynonymsH-l(3)mbt-like protein 3 KIAA1798 MBT-1 MBT1
Gene NameL3MBTL3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009817|Lethal(3)malignant brain tumor-like protein 3
MTESASSTSGQEFDVFSVMDWKDGVGTLPGSDLKFRVNEFGALEVITDENEMENVKKATA
TTTWMVPTAQEAPTSPPSSRPVFPPAYWTSPPGCPTVFSEKTGMPFRLKDPVKVEGLQFC
ENCCQYGNVDECLSGGNYCSQNCARHIKDKDQKEERDVEEDNEEEDPKCSRKKKPKLSLK
ADTKEDGEERDDEMENKQDVRILRGSQRARRKRRGDSAVLKQGLPPKGKKAWCWASYLEE
EKAVAVPAKLFKEHQSFPYNKNGFKVGMKLEGVDPEHQSVYCVLTVAEVCGYRIKLHFDG
YSDCYDFWVNADALDIHPVGWCEKTGHKLHPPKGYKEEEFNWQTYLKTCKAQAAPKSLFE
NQNITVIPSGFRVGMKLEAVDKKNPSFICVATVTDMVDNRFLVHFDNWDESYDYWCEASS
PHIHPVGWCKEHRRTLITPPGYPNVKHFSWDKYLEETNSLPAPARAFKVKPPHGFQKKMK
LEVVDKRNPMFIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPVGWCSKTGHPL
QPPLSPLELMEASEHGGCSTPGCKGIGHFKRARHLGPHSAANCPYSEINLNKDRIFPDRL
SGEMPPASPSFPRNKRTDANESSSSPEIRDQHADDVKEDFEERTESEMRTSHEARGAREE
PTVQQAQRRSAVFLSFKSPIPCLPLRWEQQSKLLPTVAGIPASKVSKWSTDEVSEFIQSL
PGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSILMFKAAEKNSHNEL
Number of residues780
Molecular Weight88336.035
Theoretical pINone
GO Classification
Functions

                

              
Processes

                

                    
    macrophage differentiation
chromatin modification
erythrocyte maturation
granulocyte differentiation
regulation of transcription, DNA-templated
transcription, DNA-templated

                

              
Components

                

                  
    nucleus

                

              

          		
      

      
General FunctionNone

      
Specific FunctionPutative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity).

      
Transmembrane Regions

      
GenBank Protein ID

      
UniProtKB IDQ96JM7  

      
UniProtKB Entry NameLMBL3_HUMAN  

      
Cellular LocationNucleus

      
Gene sequence
>lcl|BSEQ0021736|Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
ATGACTGAATCTGCCTCTAGCACAAGTGGTCAAGAGTTTGATGTGTTCAGTGTTATGGAC
TGGAAAGATGGAGTGGGCACGTTACCAGGAAGTGACTTAAAGTTTCGGGTAAATGAGTTT
GGAGCCCTGGAAGTTATTACAGATGAGAATGAGATGGAAAATGTTAAAAAAGCAACTGCT
ACCACCACTTGGATGGTACCAACTGCTCAAGAAGTCTTTTCAGAGAAGACTGGGATGCCT
TTCAGGTTGAAGGATCCAGTGAAAGTAGAAGGGCTTCAGTTCTGTGAGAACTGTTGTCAG
TATGGCAACGTAGATGAGTGTCTTTCTGGAGGAAACTATTGCAGCCAGAATTGTGCTCGG
CACATCAAAGATAAAGATCAGAAGGAAGAAAGGGACGTAGAAGAAGACAATGAGGAAGAA
GATCCTAAGTGTAGTCGGAAGAAAAAACCAAAATTATCTCTGAAAGCTGACACCAAGGAG
GATGGAGAAGAGAGAGATGATGAAATGGAGAACAAACAAGATGTAAGAATCCTGAGGGGT
TCGCAGAGAGCACGGAGGAAAAGACGAGGGGATTCGGCTGTACTAAAGCAGGGTTTGCCT
CCTAAAGGAAAGAAAGCGTGGTGCTGGGCATCCTACCTGGAAGAGGAGAAAGCGGTGGCA
GTGCCGGCGAAGCTGTTCAAGGAGCATCAATCCTTTCCATATAACAAAAATGGATTCAAA
GTTGGCATGAAATTAGAAGGCGTGGATCCTGAGCATCAGTCTGTGTACTGTGTCCTCACC
GTCGCGGAGGTTTGTGGATACCGGATAAAGCTTCACTTTGATGGGTATTCTGATTGCTAT
GACTTCTGGGTGAATGCAGACGCTCTGGATATCCACCCAGTTGGGTGGTGTGAGAAAACC
GGCCACAAACTCCATCCTCCAAAAGGGTATAAAGAAGAAGAATTCAATTGGCAGACCTAT
CTTAAGACATGTAAAGCTCAAGCTGCTCCTAAGTCATTATTTGAAAATCAGAATATAACA
GTGATCCCATCGGGCTTTCGAGTTGGTATGAAGCTTGAGGCAGTAGACAAAAAGAATCCC
TCATTCATCTGTGTTGCTACGGTAACAGATATGGTGGACAATCGTTTCCTGGTACATTTT
GACAACTGGGATGAGAGCTATGACTATTGGTGTGAAGCATCAAGTCCACATATTCATCCA
GTTGGTTGGTGTAAGGAACATAGAAGAACCCTTATTACTCCACCAGGTTATCCAAATGTG
AAACATTTTTCTTGGGATAAATACTTAGAAGAAACCAATTCTTTACCTGCTCCTGCAAGA
GCTTTCAAAGTGAAACCTCCTCATGGATTCCAGAAAAAAATGAAGCTTGAGGTTGTAGAC
AAAAGGAACCCTATGTTTATTAGAGTAGCAACTGTGGCAGACACAGATGATCACCGGGTA
AAAGTTCACTTTGATGGCTGGAACAATTGCTATGATTACTGGATAGATGCAGATTCTCCT
GATATTCACCCTGTAGGCTGGTGTTCAAAAACAGGACATCCCCTTCAGCCTCCTTTGAGC
CCCTTAGAATTAATGGAAGCTTCAGAACATGGTGGATGCTCAACCCCGGGATGTAAAGGG
ATTGGCCATTTCAAGAGAGCGAGACATCTGGGCCCTCACAGTGCTGCCAACTGTCCCTAT
TCAGAAATCAATTTGAATAAAGACCGTATTTTTCCAGACCGCTTAAGTGGTGAGATGCCT
CCGGCTAGTCCGTCATTTCCAAGAAATAAAAGGACAGATGCAAATGAAAGCTCTTCTTCC
CCTGAAATCAGAGACCAGCATGCTGATGATGTCAAAGAAGACTTTGAAGAGAGAACAGAA
AGTGAAATGAGAACATCACATGAAGCCAGAGGTGCCCGGGAAGAACCCACCGTCCAGCAG
GCACAGCGTCGGTCAGCTGTCTTTCTGTCCTTTAAGTCCCCAATTCCATGTCTGCCCTTG
CGCTGGGAGCAGCAAAGCAAACTTCTTCCAACTGTCGCAGGAATCCCTGCCAGTAAAGTT
TCCAAATGGAGCACAGACGAGGTGTCAGAATTTATACAGAGCTTACCTGGGTGTGAAGAA
CATGGAAAGGTATTTAAAGATGAACAAATTGATGGAGAAGCATTTCTACTTATGACTCAA
ACAGACATTGTTAAAATTATGAGCATTAAACTGGGCCCTGCTCTCAAAATTTTCAATTCC
ATCCTGATGTTCAAAGCTGCAGAGAAGAATTCTCACAATGAACTTTGA

      
GenBank Gene ID

      
GeneCard IDNone

      
GenAtlas ID

      
HGNC IDHGNC:23035  

      
Chromosome Location6

      
LocusNone

      
References
        
          
    
            
            
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  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334  ]
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  6. Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 2011 Mar 15;4(164):rs3. doi: 10.1126/scisignal.2001570.[21406692  ]
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Related FRC

      

    

    
        

            FRCD ID
            Name
            Exact Mass
            
            Structure
        

        
        

        
        

            
                

                



F04784
                

            		
            


Chlorpheniramine

            


274.792