Kinesin-like protein KIF16B

NameKinesin-like protein KIF16B
SynonymsC20orf23 KIAA1590 SNX23 Sorting nexin-23
Gene NameKIF16B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009137|Kinesin-like protein KIF16B
MASVKVAVRVRPMNRREKDLEAKFIIQMEKSKTTITNLKIPEGGTGDSGRERTKTFTYDF
SFYSADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDSG
LIPRICEGLFSRINETTRWDEASFRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKE
GPYVEDLSKHLVQNYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQAKFDSEM
PCETVSKIHLVDLAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANTL
AKKKQVFVPYRDSVLTWLLKDSLGGNSKTIMIATISPADVNYGETLSTLRYANRAKNIIN
KPTINEDANVKLIRELRAEIARLKTLLAQGNQIALLDSPTALSMEEKLQQNEARVQELTK
EWTNKWNETQNILKEQTLALRKEGIGVVLDSELPHLIGIDDDLLSTGIILYHLKEGQTYV
GRDDASTEQDIVLHGLDLESEHCIFENIGGTVTLIPLSGSQCSVNGVQIVEATHLNQGAV
ILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAVMLYNPGLEFER
QQREELEKLESKRKLIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKR
RSFHIENKLKDLLAEKEKFEEERLREQQEIELQKKRQEEETFLRVQEELQRLKELNNNEK
AEKFQIFQELDQLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLREKQEMIQLLR
RGEVQWVEEEKRDLEGIRESLLRVKEARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLE
KDLVQQKDILKKEVQEEQEILECLKCEHDKESRLLEKHDESVTDVTEVPQDFEKIKPVEY
RLQYKERQLQYLLQNHLPTLLEEKQRAFEILDRGPLSLDNTLYQVEKEMEEKEEQLAQYQ
ANANQLQKLQATFEFTANIARQEEKVRKKEKEILESREKQQREALERALARLERRHSALQ
RHSTLGMEIEEQRQKLASLNSGSREQSGLQASLEAEQEALEKDQERLEYEIQQLKQKIYE
VDGVQKDHHGTLEGKVASSSLPVSAEKSHLVPLMDARINAYIEEEVQRRLQDLHRVISEG
CSTSADTMKDNEKLHNGTIQRKLKYERMVSRSLGANPDDLKDPIKISIPRYVLCGQGKDA
HFEFEVKITVLDETWTVFRRYSRFREMHKTLKLKYAELAALEFPPKKLFGNKDERVIAER
RSHLEKYLRDFFSVMLQSATSPLHINKVGLTLSKHTICEFSPFFKKGVFDYSSHGTG
Number of residues1317
Molecular Weight152010.17
Theoretical pINone
GO Classification
Functions
    phosphatidylinositol-3,4-bisphosphate binding
phosphatidylinositol-3,4,5-trisphosphate binding
ATP binding
ATP-dependent microtubule motor activity, plus-end-directed
phosphatidylinositol-3,5-bisphosphate binding
phosphatidylinositol-3-phosphate binding
Processes
    regulation of receptor recycling
receptor catabolic process
early endosome to late endosome transport
microtubule-based movement
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
endoderm development
formation of primary germ layer
Golgi to endosome transport
Components
    kinesin complex
microtubule
endosome
early endosome
early endosome membrane
General FunctionPhosphatidylinositol-3-phosphate binding
Specific FunctionPlus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ96L93
UniProtKB Entry NameKI16B_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013635|Kinesin-like protein KIF16B (KIF16B)
ATGGCATCGGTCAAGGTGGCCGTGAGGGTCCGGCCCATGAATCGCAGGGAAAAGGACTTG
GAGGCCAAGTTCATTATTCAGATGGAGAAAAGCAAAACGACAATCACAAACTTAAAGATA
CCAGAAGGAGGCACTGGGGACTCAGGAAGAGAACGGACCAAGACCTTCACCTATGACTTT
TCTTTTTATTCTGCTGATACAAAAAGCCCAGATTACGTTTCACAAGAAATGGTTTTCAAA
ACCCTCGGCACAGATGTCGTGAAGTCTGCATTTGAAGGTTATAATGCTTGTGTCTTTGCA
TATGGGCAAACTGGATCTGGAAAGTCATACACTATGATGGGAAATTCTGGAGATTCTGGC
TTAATACCTCGGATCTGTGAAGGACTCTTCAGTCGGATAAATGAAACCACCAGATGGGAT
GAAGCTTCTTTTCGAACTGAAGTCAGCTACTTAGAAATTTATAACGAACGTGTGAGAGAT
CTACTTCGGCGGAAGTCATCTAAAACCTTCAATTTGAGAGTCCGTGAGCATCCCAAAGAA
GGCCCTTATGTTGAGGATTTATCCAAACATTTAGTACAGAATTATGGTGACGTAGAAGAA
CTTATGGATGCGGGCAATATCAACCGGACCACCGCAGCGACTGGGATGAACGACGTCAGT
AGCAGGTCTCATGCCATCTTCACCATCAAGTTCACTCAGGCTAAATTTGATTCTGAAATG
CCATGTGAAACCGTCAGTAAGATCCACTTGGTTGATCTTGCCGGAAGTGAGCGTGCAGAT
GCCACCGGAGCCACCGGGGTTAGGCTAAAGGAAGGGGGAAATATTAACAAGTCCCTCGTG
ACTCTGGGGAACGTCATTTCTGCCTTAGCTGATTTATCTCAGGATGCTGCAAATACTCTT
GCAAAGAAGAAGCAAGTTTTCGTGCCTTACAGGGATTCTGTGTTGACTTGGTTGTTAAAA
GATAGCCTTGGAGGAAACTCTAAAACTATCATGATTGCCACCATTTCACCTGCTGATGTC
AATTATGGAGAAACCCTAAGTACTCTTCGCTATGCAAATAGAGCCAAAAACATCATCAAC
AAGCCTACCATTAATGAGGATGCCAACGTCAAACTTATCCGTGAGCTGCGAGCTGAAATA
GCCAGACTGAAAACGCTGCTTGCTCAAGGGAATCAGATTGCCCTCTTAGACTCCCCCACA
GCTTTAAGTATGGAGGAAAAACTTCAGCAGAATGAAGCAAGAGTTCAAGAATTGACCAAG
GAATGGACAAATAAGTGGAATGAAACCCAAAATATTTTGAAAGAACAAACTCTAGCCCTC
AGGAAAGAAGGGATTGGAGTTGTTTTGGATTCTGAACTGCCTCATTTGATTGGCATCGAT
GATGACCTTTTGAGTACTGGAATCATCTTATATCATTTAAAGGAAGGTCAGACATACGTT
GGTAGAGACGATGCTTCCACGGAGCAAGATATTGTTCTTCATGGCCTTGACTTGGAGAGT
GAGCATTGCATCTTTGAAAATATCGGGGGGACAGTGACTCTGATACCCCTGAGTGGGTCC
CAGTGCTCTGTGAATGGTGTTCAGATCGTGGAGGCCACACATCTAAATCAAGGTGCTGTG
ATTCTCTTGGGAAGAACCAATATGTTTCGCTTTAACCATCCAAAGGAAGCCGCCAAGCTC
AGGGAGAAGAGGAAGAGTGGCCTTCTGTCCTCCTTCAGCTTGTCCATGACCGACCTCTCG
AAGTCCCGTGAGAACCTGTCTGCAGTCATGTTGTATAACCCCGGACTTGAATTTGAGAGG
CAACAGCGTGAAGAACTTGAAAAATTAGAAAGTAAAAGGAAACTCATAGAAGAAATGGAG
GAAAAGCAGAAATCAGACAAGGCTGAACTGGAGCGGATGCAGCAGGAGGTGGAGACCCAG
CGCAAGGAGACAGAAATCGTGCAGCTCCAGATTCGCAAGCAGGAGGAGAGCCTCAAACGC
CGCAGCTTCCACATCGAGAACAAGCTAAAGGATTTACTTGCGGAGAAGGAAAAATTTGAA
GAGGAGAGGCTGAGGGAACAGCAGGAAATCGAGCTGCAGAAGAAGAGACAAGAAGAAGAG
ACCTTTCTCCGCGTCCAAGAAGAACTCCAACGACTCAAAGAACTCAACAACAACGAGAAG
GCTGAGAAGTTTCAGATATTTCAAGAACTGGACCAGCTCCAAAAGGAAAAAGATGAACAG
TATGCCAAGCTTGAACTGGAAAAAAAGAGACTAGAGGAGCAGGAGAAGGAGCAGGTCATG
CTCGTGGCCCATCTGGAAGAGCAGCTCCGAGAGAAGCAGGAGATGATCCAGCTCCTGCGG
CGTGGGGAGGTACAGTGGGTGGAAGAGGAGAAGAGGGACCTGGAAGGCATTCGGGAATCC
CTCCTGCGGGTGAAGGAGGCTCGTGCCGGAGGGGATGAAGATGGCGAGGAGTTAGAAAAG
GCTCAACTGCGTTTCTTCGAATTCAAGAGAAGGCAGCTTGTCAAGCTAGTGAACTTGGAG
AAGGACCTGGTTCAGCAGAAAGACATCCTGAAAAAAGAAGTCCAAGAAGAACAGGAGATC
CTAGAGTGTTTAAAATGTGAACATGACAAAGAATCTAGATTGTTGGAAAAACATGATGAG
AGTGTCACAGATGTCACGGAAGTGCCTCAAGATTTCGAGAAAATAAAGCCAGTGGAGTAC
AGGCTGCAATATAAAGAACGCCAGCTACAGTACCTCCTGCAGAATCACTTGCCAACTCTG
TTGGAAGAAAAGCAGAGAGCATTTGAAATTCTTGACAGAGGCCCTCTCAGCTTAGACAAC
ACTCTTTATCAAGTAGAAAAGGAAATGGAAGAAAAAGAAGAACAGCTTGCACAGTACCAG
GCCAATGCAAACCAGCTGCAAAAGCTCCAAGCCACCTTTGAATTCACTGCCAACATTGCA
CGTCAGGAGGAAAAAGTGAGGAAAAAGGAAAAGGAGATTTTGGAGTCCAGAGAGAAGCAG
CAGAGAGAGGCGCTGGAGCGGGCCCTGGCCAGGCTGGAGAGGAGACATTCTGCGCTGCAG
AGGCACTCCACCCTGGGCATGGAGATTGAAGAGCAGAGGCAGAAACTTGCCAGTCTGAAC
AGTGGCAGCAGAGAGCAGTCAGGGCTCCAGGCTAGCCTGGAGGCTGAGCAGGAAGCCCTG
GAGAAGGACCAGGAGAGGATCAATGCTTACATTGAAGAAGAAGTCCAAAGACGCCTTCAG
GATTTGCATCGTGTGATTAGTGAAGGCTGCAGTACATCTGCAGACACGATGAAGGATAAT
GAGAAACTTCACAATGGCACCATTCAACGTAAACTAAAATATGAGCGGATGGTTTCTCGC
TCTTTGGGCGCAAATCCAGATGACCTGAAGGACCCAATTAAAATTAGTATCCCACGCTAC
GTCCTCTGCGGGCAAGGAAAGGATGCACACTTCGAGTTTGAGGTCAAGATTACTGTCCTA
GATGAGACATGGACTGTATTCAGGCGTTACAGTCGTTTTCGAGAAATGCATAAAACATTG
AAGTTAAAGTATGCAGAGCTTGCTGCCCTTGAATTTCCTCCAAAGAAACTATTTGGAAAT
AAGGATGAACGTGTGATTGCTGAGAGACGAAGTCACTTAGAGAAATACCTCAGGGACTTT
TTCAGCGTGATGCTCCAGTCCGCAACATCTCCCCTCCACATCAACAAAGTGGGACTGACT
CTCTCGAAACATACCATTTGTGAGTTTTCACCATTCTTCAAGAAAGGAGTCTTTGACTAC
AGCAGCCACGGGACGGGGTAG
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:15869
Chromosome Location20
LocusNone
References
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